Annotations: 4WSI

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07653	e4wsiA3	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF07653	ECOD (1.6)
A	PF00595	e4wsiA1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)
A	PF00625	e4wsiA2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00625	ECOD (1.6)
B	PF07653	e4wsiB3	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF07653	ECOD (1.6)
B	PF00595	e4wsiB2	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)
B	PF00625	e4wsiB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00625	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
A	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
B	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00625	Guanylate kinase (Guanylate_kin)	Guanylate kinase	-	Domain
A, B	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	MAGUK p55 subfamily member 5	protein binding binding protein domain specific binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding protein binding binding protein domain specific binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding identical protein binding	developmental process multicellular organismal process cellular developmental process central nervous system neuron development cell development nervous system development generation of neurons central nervous system neuron differentiation multicellular organism development neurogenesis central nervous system development neuron differentiation cell differentiation neuron development anatomical structure development developmental process multicellular organismal process cellular developmental process central nervous system neuron development cell development nervous system development generation of neurons central nervous system neuron differentiation multicellular organism development neurogenesis central nervous system development neuron differentiation cell differentiation neuron development anatomical structure development cellular process system development tissue morphogenesis anatomical structure morphogenesis epithelium development morphogenesis of an epithelium tissue development morphogenesis of an epithelial sheet cellular response to stimulus cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process response to stimulus signaling cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction regulation of transforming growth factor beta receptor signaling pathway cell communication cellular response to endogenous stimulus signal transduction enzyme-linked receptor protein signaling pathway regulation of biological process regulation of signaling cell surface receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus biological regulation response to transforming growth factor beta regulation of response to stimulus transforming growth factor beta receptor signaling pathway regulation of cell communication response to growth factor transforming growth factor beta receptor superfamily signaling pathway cellular component assembly involved in morphogenesis myelin assembly cellular component organization cellular component biogenesis myelination cellular anatomical entity morphogenesis cellular component assembly axon ensheathment ensheathment of neurons anatomical structure formation involved in morphogenesis cellular component organization or biogenesis protein localization localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane morphogenesis of embryonic epithelium embryonic morphogenesis establishment or maintenance of cell polarity embryo development establishment or maintenance of polarity of embryonic epithelium head development forebrain development animal organ development brain development pallium development cerebral cortex development telencephalon development organic substance metabolic process biosynthetic process cellular biosynthetic process cellular metabolic process organic substance biosynthetic process metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process protein localization to myelin sheath abaxonal region peripheral nervous system axon ensheathment glial cell development gliogenesis plasma membrane organization myelination in peripheral nervous system peripheral nervous system myelin maintenance Schwann cell differentiation endomembrane system organization membrane organization peripheral nervous system development Schwann cell development glial cell differentiation myelin maintenance establishment or maintenance of bipolar cell polarity establishment or maintenance of epithelial cell apical/basal polarity establishment or maintenance of apical/basal cell polarity	somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity cell periphery apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity cell periphery apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle myelin sheath adaxonal region myelin sheath intracellular anatomical structure cytoplasm protein-containing complex apical junction complex cell-cell junction anchoring junction cell junction adherens junction intracellular organelle Golgi apparatus intracellular membrane-bounded organelle endomembrane system compact myelin Schmidt-Lanterman incisure bounding membrane of organelle endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment organelle membrane bicellular tight junction tight junction axon cell projection neuron projection plasma membrane bounded cell projection lateral loop
C [auth X], D [auth Y]	Protein crumbs	protein binding binding signaling receptor binding Notch binding cytoskeletal protein binding spectrin binding protein-containing complex binding cation binding ion binding calcium ion binding metal ion binding small molecule binding kinase binding protein kinase C binding protein binding binding signaling receptor binding Notch binding cytoskeletal protein binding spectrin binding protein-containing complex binding cation binding ion binding calcium ion binding metal ion binding small molecule binding kinase binding protein kinase C binding enzyme binding protein kinase binding	adherens junction organization cellular component organization cell junction organization cellular process cellular component organization or biogenesis cell-cell junction organization developmental process multicellular organismal process gland development animal organ development salivary gland development anatomical structure morphogenesis multicellular organism development gland morphogenesis adherens junction organization cellular component organization cell junction organization cellular process cellular component organization or biogenesis cell-cell junction organization developmental process multicellular organismal process gland development animal organ development salivary gland development anatomical structure morphogenesis multicellular organism development gland morphogenesis salivary gland morphogenesis anatomical structure development animal organ morphogenesis exocrine system development system development regulation of protein stability biological regulation regulation of biological quality protein stabilization adherens junction assembly apical junction assembly cellular component biogenesis cellular component assembly cell junction assembly zonula adherens assembly cell-cell junction assembly localization centrosome localization microtubule organizing center localization respiratory system development open tracheal system development cell division tube morphogenesis tube development nuclear chromosome segregation cell cycle chromosome segregation cell cycle process cellular developmental process rhabdomere development sensory organ development photoreceptor cell differentiation cell projection organization plasma membrane bounded cell projection morphogenesis visual system development cell development neuron projection development cell morphogenesis eye morphogenesis neurogenesis photoreceptor cell morphogenesis cell projection morphogenesis compound eye morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation eye photoreceptor cell differentiation sensory system development photoreceptor cell development plasma membrane bounded cell projection organization eye development eye photoreceptor cell development nervous system development compound eye photoreceptor development cell morphogenesis involved in neuron differentiation generation of neurons compound eye development organelle organization sensory organ morphogenesis compound eye photoreceptor cell differentiation rhabdomere morphogenesis neuron development regulation of biological process regulation of growth regulation of developmental growth regulation of developmental process developmental growth negative regulation of developmental process growth negative regulation of biological process organ growth negative regulation of organ growth negative regulation of developmental growth negative regulation of growth regulation of organ growth regulation of multicellular organismal process negative regulation of multicellular organismal process trachea development regulation of imaginal disc growth imaginal disc growth imaginal disc development protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of cellular process regulation of protein localization transport cellular macromolecule localization establishment of localization in cell regulation of intracellular transport regulation of transport organic substance transport regulation of establishment of protein localization intracellular transport regulation of protein transport establishment of localization protein transport regulation of cellular localization macromolecule localization regulation of intracellular protein transport intracellular protein transport catabolic process negative regulation of proteolysis negative regulation of proteolysis involved in protein catabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process negative regulation of protein catabolic process organic substance metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis modification-dependent macromolecule catabolic process proteolysis protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of ubiquitin-dependent protein catabolic process organonitrogen compound catabolic process negative regulation of catabolic process negative regulation of proteasomal ubiquitin-dependent protein catabolic process organonitrogen compound metabolic process regulation of protein metabolic process negative regulation of metabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process regulation of macromolecule metabolic process regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process negative regulation of proteasomal protein catabolic process regulation of proteasomal protein catabolic process ubiquitin-dependent protein catabolic process metabolic process macromolecule metabolic process organic substance catabolic process regulation of metabolic process regulation of protein catabolic process establishment or maintenance of cell polarity Malpighian tubule development embryo development renal system development renal tubule development hindgut development epithelial tube morphogenesis epithelium development Malpighian tubule morphogenesis digestive system development embryonic morphogenesis hindgut morphogenesis morphogenesis of an epithelium tissue development digestive tract development tissue morphogenesis digestive tract morphogenesis embryonic hindgut morphogenesis renal tubule morphogenesis dorsal/ventral pattern formation, imaginal disc wing disc development pattern specification process wing disc dorsal/ventral pattern formation regionalization imaginal disc pattern formation dorsal/ventral pattern formation wing disc pattern formation apical protein localization morphogenesis of embryonic epithelium dorsal closure embryonic development via the syncytial blastoderm dorsal closure, amnioserosa morphology change embryo development ending in birth or egg hatching homeostatic process tissue homeostasis amnioserosa maintenance multicellular organismal-level homeostasis anatomical structure homeostasis actin cytoskeleton organization actomyosin structure organization cortical cytoskeleton organization assembly of apicomedial cortex actomyosin cortical actin cytoskeleton organization actin filament-based process cytoskeleton organization cellular component maintenance adherens junction maintenance cell junction maintenance zonula adherens maintenance cell-cell junction maintenance actin filament-based movement epithelial cell differentiation epithelial cell development epithelial cell morphogenesis actin-mediated cell contraction apical constriction establishment or maintenance of bipolar cell polarity establishment or maintenance of apical/basal cell polarity maintenance of cell polarity maintenance of apical/basal cell polarity morphogenesis of follicular epithelium establishment or maintenance of polarity of follicular epithelium establishment or maintenance of polarity of embryonic epithelium cellular response to stimulus hippo signaling positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction signal transduction positive regulation of cellular process regulation of signaling positive regulation of intracellular signal transduction regulation of response to stimulus positive regulation of hippo signaling regulation of cell communication regulation of hippo signaling positive regulation of signaling negative regulation of signaling negative regulation of cell communication negative regulation of cellular process cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction Notch signaling pathway negative regulation of Notch signaling pathway regulation of Notch signaling pathway epithelial fluid transport liquid clearance, open tracheal system fluid transport transepithelial transport retina homeostasis photoreceptor cell maintenance membrane organization cell morphogenesis involved in Malpighian tubule morphogenesis	membrane-bounded organelle ciliary transition zone non-motile cilium 9+0 non-motile cilium cilium neuron projection cellular anatomical entity plasma membrane bounded cell projection cell projection photoreceptor cell cilium organelle photoreceptor connecting cilium rhabdomere intracellular anatomical structure membrane-bounded organelle ciliary transition zone non-motile cilium 9+0 non-motile cilium cilium neuron projection cellular anatomical entity plasma membrane bounded cell projection cell projection photoreceptor cell cilium organelle photoreceptor connecting cilium rhabdomere intracellular anatomical structure cytoplasm intracellular organelle cytoskeleton spindle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle cell periphery apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane rhabdomere membrane cell projection membrane cell-cell junction protein-containing complex plasma membrane protein complex anchoring junction membrane protein complex apical junction complex cell junction subapical complex apicolateral plasma membrane nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR008145	Guanylate kinase/L-type calcium channel beta subunit	Domain
A, B	IPR004172	L27 domain	Domain
A, B	IPR014775	L27 domain, C-terminal	Domain
A, B	IPR015145	L27-N	Domain
A, B	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A, B	IPR020590	Guanylate kinase, conserved site	Conserved Site
A, B	IPR035601	MPP5, SH3 domain	Domain
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR036034	PDZ superfamily	Homologous Superfamily
A, B	IPR001452	SH3 domain	Domain
A, B	IPR036892	L27 domain superfamily	Homologous Superfamily
A, B	IPR008144	Guanylate kinase-like domain	Domain
A, B	IPR001478	PDZ domain	Domain
C [auth X], D [auth Y]	IPR018097	EGF-like calcium-binding, conserved site	Conserved Site
C [auth X], D [auth Y]	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
C [auth X], D [auth Y]	IPR013032	EGF-like, conserved site	Conserved Site
C [auth X], D [auth Y]	IPR001881	EGF-like calcium-binding domain	Domain
C [auth X], D [auth Y]	IPR000742	EGF-like domain	Domain
C [auth X], D [auth Y]	IPR001791	Laminin G domain	Domain
C [auth X], D [auth Y]	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
C [auth X], D [auth Y]	IPR000152	EGF-type aspartate/asparagine hydroxylation site	PTM

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q8N3R9	atypical teratoid rhabdoid tumor malignant ependymoma ulcerative colitis interstitial cystitis medulloblastoma large cell medulloblastoma ovarian cancer