4WPM

Structure of the Chaetomium thermophilum Mex67:Mtr2 Complex

External Resource: Annotation


Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APF18444e4wpmA1 A: a+b two layersX: Alpha-beta plaitsH: RNA-binding domain, RBD (From Topology)T: RNA-binding domain, RBDF: PF18444ECOD (1.6)
BPF18444e4wpmB1 A: a+b two layersX: Alpha-beta plaitsH: RNA-binding domain, RBD (From Topology)T: RNA-binding domain, RBDF: PF18444ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF18444RNA recognition motif (RRM_9)RNA recognition motifThe Mex67-Mtr2 complex (TAP-p15 or NXF1-NXT1 in metazoans) is the principal mRNA export factor in Saccharomyces cerevisiae. Mex67 is a member of the NXF family of proteins and has conserved homologs through eukaryotes from yeast to humans. Although s ...The Mex67-Mtr2 complex (TAP-p15 or NXF1-NXT1 in metazoans) is the principal mRNA export factor in Saccharomyces cerevisiae. Mex67 is a member of the NXF family of proteins and has conserved homologs through eukaryotes from yeast to humans. Although sequence conservation is poor between S. cerevisiae Mex67 and Homo sapiens NXF1, they do show functional complementarity. Mex67 and TAP/NXF1 are modular proteins that contain four structural domains: an N-terminal RNA recognition motif (RRM), a leucine rich repeat (LRR) domain, a nuclear transport factor 2-like domain (NTF2L) and an ubiquitin-associated domain (UBA). This entry describes the N-terminal RNA recognition motif (RRM) found in Mex67 proteins [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
mRNA export protein-

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B
IPR030217Nuclear RNA export factorFamily
A, B
IPR032710NTF2-like domain superfamilyHomologous Superfamily
A, B
IPR032675Leucine-rich repeat domain superfamilyHomologous Superfamily
A, B
IPR040736Mex67, RNA recognition motifDomain
A, B
IPR001611Leucine-rich repeatRepeat
A, B
IPR009060UBA-like superfamilyHomologous Superfamily
A, B
IPR005637TAP C-terminal (TAP-C) domainDomain
A, B
IPR018222Nuclear transport factor 2, eukaryoteDomain