4WJ7

CCM2 PTB domain in complex with KRIT1 NPxY/F3

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ICAP-1_inte_bdg	e4wj7A1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: ICAP-1_inte_bdg	ECOD (1.6)
B	ICAP-1_inte_bdg	e4wj7B1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: ICAP-1_inte_bdg	ECOD (1.6)
C	ICAP-1_inte_bdg	e4wj7C1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: ICAP-1_inte_bdg	ECOD (1.6)
D	ICAP-1_inte_bdg	e4wj7D1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: ICAP-1_inte_bdg	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
B	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
C	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
D	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Malcavernin	-	developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis regulation of angiogenesis anatomical structure development anatomical structure formation involved in morphogenesis regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development system development heart development animal organ development epithelium development tissue development pericardium development venous blood vessel development venous blood vessel morphogenesis endothelial cell differentiation cellular developmental process endothelium development cell development epithelial cell differentiation endothelial cell development epithelial cell development cell differentiation cellular process vasculogenesis cellular response to stimulus regulation of cellular process response to stimulus signaling intracellular signal transduction cell communication stress-activated MAPK cascade stress-activated protein kinase signaling cascade cellular response to stress response to stress intracellular signaling cassette MAPK cascade signal transduction blood vessel endothelial cell differentiation ear development sensory organ development inner ear development integrin-mediated signaling pathway cell surface receptor signaling pathway multicellular organism growth developmental growth growth morphogenesis of an endothelium endothelial tube morphogenesis morphogenesis of an epithelium tissue morphogenesis epithelial tube morphogenesis cellular component organization cell junction organization cellular component organization or biogenesis cell-cell junction organization embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex
E [auth W], F [auth X], G [auth Y], H [auth Z]	KRIT1 NPxY/F3	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR006020	PTB/PI domain	Domain
A, B, C, D	IPR032375	Cerebral cavernous malformations 2, harmonin-homology domain	Domain
A, B, C, D	IPR026159	Cerebral cavernous malformations 2	Family
A, B, C, D	IPR011993	PH-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q9BSQ5	cerebral cavernous malformation 2 Hemangioma, Cavernous, Central Nervous System cerebrovascular disorder pancreatic ductal adenocarcinoma atypical teratoid rhabdoid tumor colorectal adenoma heart disease malignant ependymoma pilocytic astrocytoma cerebral cavernous malformation cerebrocostomandibular syndrome colorectal cancer ovarian cancer cavernous hemangioma cerebral cavernous malformation 1 cerebral cavernous malformation 2 Hemangioma, Cavernous, Central Nervous System cerebrovascular disorder pancreatic ductal adenocarcinoma atypical teratoid rhabdoid tumor colorectal adenoma heart disease malignant ependymoma pilocytic astrocytoma cerebral cavernous malformation cerebrocostomandibular syndrome colorectal cancer ovarian cancer cavernous hemangioma cerebral cavernous malformation 1 famililal cerebral cavernous malformations large cell medulloblastoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.