4V8L

Cryo-EM Structure of the Mycobacterial Fatty Acid Synthase

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth D]	PF08354	e4v8lD3	A: alpha bundles	X: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	H: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	T: Inserted helical domain in fatty acid synthase subunit beta	F: PF08354	ECOD (1.6)
A [auth D]	PF18314	e4v8lD10	A: alpha complex topology	X: FAS type I helical domain (From Topology)	H: FAS type I helical domain (From Topology)	T: FAS type I helical domain	F: PF18314	ECOD (1.6)
A [auth D]	F_UNCLASSIFIED	e4v8lD11	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: F_UNCLASSIFIED	ECOD (1.6)
A [auth D]	PF01575	e4v8lD7	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF01575	ECOD (1.6)
A [auth D]	F_UNCLASSIFIED	e4v8lD6	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: F_UNCLASSIFIED	ECOD (1.6)
A [auth D]	PF22690	e4v8lD12	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: PF22690	ECOD (1.6)
A [auth D]	PF18094	e4v8lD1	A: a+b two layers	X: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	H: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	T: Meander beta sheet domain in fatty acid synthase subunit beta	F: PF18094	ECOD (1.6)
A [auth D]	PF08354	e4v8lD9	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF08354	ECOD (1.6)
A [auth D]	F_UNCLASSIFIED	e4v8lD4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
A [auth D]	PF00698	e4v8lD13	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: PF00698	ECOD (1.6)
A [auth D]	PF16073	e4v8lD8	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: PF16073	ECOD (1.6)
A [auth D]	PF00109	e4v8lD5	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF00109	ECOD (1.6)
A [auth D]	PF02801	e4v8lD2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF02801	ECOD (1.6)
C [auth F]	PF08354	e4v8lF3	A: alpha bundles	X: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	H: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	T: Inserted helical domain in fatty acid synthase subunit beta	F: PF08354	ECOD (1.6)
C [auth F]	PF18314	e4v8lF10	A: alpha complex topology	X: FAS type I helical domain (From Topology)	H: FAS type I helical domain (From Topology)	T: FAS type I helical domain	F: PF18314	ECOD (1.6)
C [auth F]	F_UNCLASSIFIED	e4v8lF11	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth F]	PF01575	e4v8lF7	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF01575	ECOD (1.6)
C [auth F]	F_UNCLASSIFIED	e4v8lF6	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth F]	PF22690	e4v8lF12	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: PF22690	ECOD (1.6)
C [auth F]	PF18094	e4v8lF1	A: a+b two layers	X: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	H: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	T: Meander beta sheet domain in fatty acid synthase subunit beta	F: PF18094	ECOD (1.6)
C [auth F]	PF08354	e4v8lF9	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF08354	ECOD (1.6)
C [auth F]	F_UNCLASSIFIED	e4v8lF4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth F]	PF00698	e4v8lF13	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: PF00698	ECOD (1.6)
C [auth F]	PF16073	e4v8lF8	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: PF16073	ECOD (1.6)
C [auth F]	PF00109	e4v8lF5	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF00109	ECOD (1.6)
C [auth F]	PF02801	e4v8lF2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF02801	ECOD (1.6)
D [auth A]	PF08354	e4v8lA3	A: alpha bundles	X: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	H: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	T: Inserted helical domain in fatty acid synthase subunit beta	F: PF08354	ECOD (1.6)
D [auth A]	PF18314	e4v8lA10	A: alpha complex topology	X: FAS type I helical domain (From Topology)	H: FAS type I helical domain (From Topology)	T: FAS type I helical domain	F: PF18314	ECOD (1.6)
D [auth A]	F_UNCLASSIFIED	e4v8lA11	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth A]	PF01575	e4v8lA7	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF01575	ECOD (1.6)
D [auth A]	F_UNCLASSIFIED	e4v8lA6	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth A]	PF22690	e4v8lA12	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: PF22690	ECOD (1.6)
D [auth A]	PF18094	e4v8lA1	A: a+b two layers	X: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	H: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	T: Meander beta sheet domain in fatty acid synthase subunit beta	F: PF18094	ECOD (1.6)
D [auth A]	PF08354	e4v8lA9	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF08354	ECOD (1.6)
D [auth A]	F_UNCLASSIFIED	e4v8lA4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth A]	PF00698	e4v8lA13	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: PF00698	ECOD (1.6)
D [auth A]	PF16073	e4v8lA8	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: PF16073	ECOD (1.6)
D [auth A]	PF00109	e4v8lA5	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF00109	ECOD (1.6)
D [auth A]	PF02801	e4v8lA2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF02801	ECOD (1.6)
E [auth B]	PF08354	e4v8lB3	A: alpha bundles	X: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	H: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	T: Inserted helical domain in fatty acid synthase subunit beta	F: PF08354	ECOD (1.6)
E [auth B]	PF18314	e4v8lB10	A: alpha complex topology	X: FAS type I helical domain (From Topology)	H: FAS type I helical domain (From Topology)	T: FAS type I helical domain	F: PF18314	ECOD (1.6)
E [auth B]	F_UNCLASSIFIED	e4v8lB11	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth B]	PF01575	e4v8lB7	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF01575	ECOD (1.6)
E [auth B]	F_UNCLASSIFIED	e4v8lB6	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth B]	PF22690	e4v8lB12	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: PF22690	ECOD (1.6)
E [auth B]	PF18094	e4v8lB1	A: a+b two layers	X: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	H: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	T: Meander beta sheet domain in fatty acid synthase subunit beta	F: PF18094	ECOD (1.6)
E [auth B]	PF08354	e4v8lB9	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF08354	ECOD (1.6)
E [auth B]	F_UNCLASSIFIED	e4v8lB4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth B]	PF00698	e4v8lB13	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: PF00698	ECOD (1.6)
E [auth B]	PF16073	e4v8lB8	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: PF16073	ECOD (1.6)
E [auth B]	PF00109	e4v8lB5	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF00109	ECOD (1.6)
E [auth B]	PF02801	e4v8lB2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF02801	ECOD (1.6)
F [auth C]	PF08354	e4v8lC3	A: alpha bundles	X: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	H: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	T: Inserted helical domain in fatty acid synthase subunit beta	F: PF08354	ECOD (1.6)
F [auth C]	PF18314	e4v8lC10	A: alpha complex topology	X: FAS type I helical domain (From Topology)	H: FAS type I helical domain (From Topology)	T: FAS type I helical domain	F: PF18314	ECOD (1.6)
F [auth C]	F_UNCLASSIFIED	e4v8lC11	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: F_UNCLASSIFIED	ECOD (1.6)
F [auth C]	PF01575	e4v8lC7	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF01575	ECOD (1.6)
F [auth C]	F_UNCLASSIFIED	e4v8lC6	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: F_UNCLASSIFIED	ECOD (1.6)
F [auth C]	PF22690	e4v8lC12	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: PF22690	ECOD (1.6)
F [auth C]	PF18094	e4v8lC1	A: a+b two layers	X: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	H: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	T: Meander beta sheet domain in fatty acid synthase subunit beta	F: PF18094	ECOD (1.6)
F [auth C]	PF08354	e4v8lC9	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF08354	ECOD (1.6)
F [auth C]	F_UNCLASSIFIED	e4v8lC4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
F [auth C]	PF00698	e4v8lC13	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: PF00698	ECOD (1.6)
F [auth C]	PF16073	e4v8lC8	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: PF16073	ECOD (1.6)
F [auth C]	PF00109	e4v8lC5	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF00109	ECOD (1.6)
F [auth C]	PF02801	e4v8lC2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF02801	ECOD (1.6)
B [auth E]	PF08354	e4v8lE3	A: alpha bundles	X: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	H: Inserted helical domain in fatty acid synthase subunit beta (From Topology)	T: Inserted helical domain in fatty acid synthase subunit beta	F: PF08354	ECOD (1.6)
B [auth E]	PF18314	e4v8lE10	A: alpha complex topology	X: FAS type I helical domain (From Topology)	H: FAS type I helical domain (From Topology)	T: FAS type I helical domain	F: PF18314	ECOD (1.6)
B [auth E]	F_UNCLASSIFIED	e4v8lE11	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth E]	PF01575	e4v8lE7	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF01575	ECOD (1.6)
B [auth E]	F_UNCLASSIFIED	e4v8lE6	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth E]	PF22690	e4v8lE12	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: PF22690	ECOD (1.6)
B [auth E]	PF18094	e4v8lE1	A: a+b two layers	X: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	H: Meander beta sheet domain in fatty acid synthase subunit beta (From Topology)	T: Meander beta sheet domain in fatty acid synthase subunit beta	F: PF18094	ECOD (1.6)
B [auth E]	PF08354	e4v8lE9	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF08354	ECOD (1.6)
B [auth E]	F_UNCLASSIFIED	e4v8lE4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth E]	PF00698	e4v8lE13	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: PF00698	ECOD (1.6)
B [auth E]	PF16073	e4v8lE8	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: PF16073	ECOD (1.6)
B [auth E]	PF00109	e4v8lE5	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF00109	ECOD (1.6)
B [auth E]	PF02801	e4v8lE2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF02801	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	PF02801	Beta-ketoacyl synthase, C-terminal domain (Ketoacyl-synt_C)	Beta-ketoacyl synthase, C-terminal domain	The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.	Domain
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	PF16073	Starter unit:ACP transacylase in aflatoxin biosynthesis (SAT)	Starter unit:ACP transacylase in aflatoxin biosynthesis	-	Family
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	PF08354	Fatty acid synthase subunit beta/Fas1-like, helical (Fas1-AflB-like_hel)	Fatty acid synthase subunit beta/Fas1-like, helical	This domain has been identified in fungi and bacteria. It is found in fatty acid synthase beta subunit from fungi, including Fas1 from yeasts and aflB from Aspergillus parasiticus. This is an inserted helical domain, whose function is not clear, and ...	This domain has been identified in fungi and bacteria. It is found in fatty acid synthase beta subunit from fungi, including Fas1 from yeasts and aflB from Aspergillus parasiticus. This is an inserted helical domain, whose function is not clear, and is found together with the MaoC-like domain (Pfam:PF01575) and the acyltransferase domain (Pfam:PF00698) [1]. Fas1 is a fatty acid synthetase that catalyses the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH [2]. AflB is part of the gene cluster that mediates the biosynthesis of aflatoxins [3].	Domain
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	PF00109	Beta-ketoacyl synthase, N-terminal domain (ketoacyl-synt)	Beta-ketoacyl synthase, N-terminal domain	The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains m ...	The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains most of the structures involved in dimer formation and also the active site cysteine [1].	Domain
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	PF18094	DNA polymerase beta N-terminal domain (DNA_pol_B_N)	DNA polymerase beta N-terminal domain	This is the N-terminal domain of DNA polymerase beta present in Homo sapiens. DNA polymerase beta is a repair enzyme that has a key role in the base excision repair of simple DNA lesions [1].	Domain
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	PF01575	MaoC like domain (MaoC_dehydratas)	MaoC like domain	The maoC gene is part of a operon with maoA which is involved in the synthesis of monoamine oxidase [1]. The MaoC protein is found to share similarity with a wide variety of enzymes; estradiol 17 beta-dehydrogenase 4, peroxisomal hydratase-dehydroge ...	The maoC gene is part of a operon with maoA which is involved in the synthesis of monoamine oxidase [1]. The MaoC protein is found to share similarity with a wide variety of enzymes; estradiol 17 beta-dehydrogenase 4, peroxisomal hydratase-dehydrogenase-epimerase, fatty acid synthase beta subunit. Several bacterial proteins that are composed solely of this domain have (R)-specific enoyl-CoA hydratase activity [2]. This domain is also present in the NodN nodulation protein N.	Domain
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	PF00698	Acyl transferase domain (Acyl_transf_1)	Acyl transferase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	FATTY ACID SYNTHASE	enoyl-[acyl-carrier-protein] reductase (NADH) activity oxidoreductase activity enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H) oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the CH-CH group of donors catalytic activity fatty acid synthase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity hydrolase activity	fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process organic substance metabolic process biosynthetic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cellular lipid metabolic process small molecule metabolic process metabolic process cellular process monocarboxylic acid metabolic process lipid metabolic process	protein-containing complex catalytic complex fatty acid synthase complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase	Homologous Superfamily
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	IPR014031	Beta-ketoacyl synthase, C-terminal	Domain
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	IPR014030	Beta-ketoacyl synthase, N-terminal	Domain
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	IPR003965	Fatty acid synthase	Domain
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	IPR029069	HotDog domain superfamily	Homologous Superfamily
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	IPR002539	MaoC-like dehydratase domain	Domain
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	IPR016039	Thiolase-like	Homologous Superfamily
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	IPR001227	Acyl transferase domain superfamily	Homologous Superfamily
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	IPR047224	Fatty acid synthase subunit alpha-like, C-terminal	Domain
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	IPR014043	Acyl transferase	Domain
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	IPR020841	Polyketide synthase, beta-ketoacyl synthase domain	Domain
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	IPR032088	Starter unit:ACP transacylase	Domain
A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], A [auth D], B [auth E], C [auth F], D [auth A], E [auth B], F [auth C]	IPR013565	Fatty acid synthase beta subunit AflB /Fas1-like, central domain	Domain