4V6H

Crystal structure of succinate-semialdehyde dehydrogenase from Burkholderia pseudomallei

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
AA [auth 1]	SCOP2 Family	ALDH-like	8065607	4000806	SCOP2 (2022-06-29)
AA [auth 1]	SCOP2 Superfamily	ALDH-like	8065608	3001479	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
BA [auth 2]	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
CA [auth 3]	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
DA [auth 4]	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
EA [auth 5]	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
FA [auth 6]	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
S	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
U	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
V	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
W	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
X	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
Y	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)
Z	SCOP2B Superfamily	ALDH-like	8065608	3001479	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Aldedh_2nd	e4v6hA2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
A	Aldedh_1st_1	e4v6hA1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
AA [auth 1]	Aldedh_2nd	e4v6h12	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
AA [auth 1]	Aldedh_1st_1	e4v6h11	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
B	Aldedh_2nd	e4v6hB1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
B	Aldedh_1st_1	e4v6hB2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
BA [auth 2]	Aldedh_2nd	e4v6h21	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
BA [auth 2]	Aldedh_1st_1	e4v6h22	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
C	Aldedh_2nd	e4v6hC2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
C	Aldedh_1st_1	e4v6hC1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
CA [auth 3]	Aldedh_2nd	e4v6h32	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
CA [auth 3]	Aldedh_1st_1	e4v6h31	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
D	Aldedh_2nd	e4v6hD2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
D	Aldedh_1st_1	e4v6hD1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
DA [auth 4]	Aldedh_2nd	e4v6h41	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
DA [auth 4]	Aldedh_1st_1	e4v6h42	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
E	Aldedh_2nd	e4v6hE2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
E	Aldedh_1st_1	e4v6hE1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
EA [auth 5]	Aldedh_2nd	e4v6h52	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
EA [auth 5]	Aldedh_1st_1	e4v6h51	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
F	Aldedh_2nd	e4v6hF1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
F	Aldedh_1st_1	e4v6hF2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
FA [auth 6]	Aldedh_2nd	e4v6h61	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
FA [auth 6]	Aldedh_1st_1	e4v6h62	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
G	Aldedh_2nd	e4v6hG1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
G	Aldedh_1st_1	e4v6hG2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
H	Aldedh_2nd	e4v6hH2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
H	Aldedh_1st_1	e4v6hH1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
I	Aldedh_2nd	e4v6hI1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
I	Aldedh_1st_1	e4v6hI2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
J	Aldedh_2nd	e4v6hJ1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
J	Aldedh_1st_1	e4v6hJ2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
K	Aldedh_2nd	e4v6hK1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
K	Aldedh_1st_1	e4v6hK2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
L	Aldedh_2nd	e4v6hL2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
L	Aldedh_1st_1	e4v6hL1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
M	Aldedh_2nd	e4v6hM2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
M	Aldedh_1st_1	e4v6hM1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
N	Aldedh_2nd	e4v6hN2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
N	Aldedh_1st_1	e4v6hN1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
O	Aldedh_2nd	e4v6hO1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
O	Aldedh_1st_1	e4v6hO2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
P	Aldedh_2nd	e4v6hP2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
P	Aldedh_1st_1	e4v6hP1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
Q	Aldedh_2nd	e4v6hQ2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
Q	Aldedh_1st_1	e4v6hQ1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
R	Aldedh_2nd	e4v6hR2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
R	Aldedh_1st_1	e4v6hR1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
S	Aldedh_2nd	e4v6hS2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
S	Aldedh_1st_1	e4v6hS1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
T	Aldedh_2nd	e4v6hT1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
T	Aldedh_1st_1	e4v6hT2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
U	Aldedh_2nd	e4v6hU1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
U	Aldedh_1st_1	e4v6hU2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
V	Aldedh_2nd	e4v6hV2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
V	Aldedh_1st_1	e4v6hV1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
W	Aldedh_2nd	e4v6hW2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
W	Aldedh_1st_1	e4v6hW1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
X	Aldedh_2nd	e4v6hX1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
X	Aldedh_1st_1	e4v6hX2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
Y	Aldedh_2nd	e4v6hY2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
Y	Aldedh_1st_1	e4v6hY1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
Z	Aldedh_2nd	e4v6hZ1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
Z	Aldedh_1st_1	e4v6hZ2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, AA [auth 1], B, BA [auth 2], C, A, AA [auth 1], B, BA [auth 2], C, CA [auth 3], D, DA [auth 4], E, EA [auth 5], F, FA [auth 6], G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z	PF00171	Aldehyde dehydrogenase family (Aldedh)	Aldehyde dehydrogenase family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, AA [auth 1], B, BA [auth 2], C, A, AA [auth 1], B, BA [auth 2], C, CA [auth 3], D, DA [auth 4], E, EA [auth 5], F, FA [auth 6], G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z	Succinate-semialdehyde dehydrogenase (NADP+)	oxidoreductase activity succinate-semialdehyde dehydrogenase [NAD(P)+] activity oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	catabolic process gamma-aminobutyric acid metabolic process oxoacid metabolic process amino acid metabolic process organic acid catabolic process organic acid metabolic process cellular catabolic process non-proteinogenic amino acid metabolic process organic substance metabolic process carboxylic acid catabolic process small molecule metabolic process amino acid catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process gamma-aminobutyric acid metabolic process oxoacid metabolic process amino acid metabolic process organic acid catabolic process organic acid metabolic process cellular catabolic process non-proteinogenic amino acid metabolic process organic substance metabolic process carboxylic acid catabolic process small molecule metabolic process amino acid catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process non-proteinogenic amino acid catabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process gamma-aminobutyric acid catabolic process metabolic process cellular process monocarboxylic acid metabolic process small molecule catabolic process organic substance catabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, AA [auth 1], B, BA [auth 2], C, A, AA [auth 1], B, BA [auth 2], C, CA [auth 3], D, DA [auth 4], E, EA [auth 5], F, FA [auth 6], G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z	IPR010102	Succinate semialdehyde dehydrogenase	Family
A, AA [auth 1], B, BA [auth 2], C, A, AA [auth 1], B, BA [auth 2], C, CA [auth 3], D, DA [auth 4], E, EA [auth 5], F, FA [auth 6], G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z	IPR015590	Aldehyde dehydrogenase domain	Domain
A, AA [auth 1], B, BA [auth 2], C, A, AA [auth 1], B, BA [auth 2], C, CA [auth 3], D, DA [auth 4], E, EA [auth 5], F, FA [auth 6], G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z	IPR016161	Aldehyde/histidinol dehydrogenase	Homologous Superfamily
A, AA [auth 1], B, BA [auth 2], C, A, AA [auth 1], B, BA [auth 2], C, CA [auth 3], D, DA [auth 4], E, EA [auth 5], F, FA [auth 6], G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z	IPR029510	Aldehyde dehydrogenase, glutamic acid active site	Conserved Site
A, AA [auth 1], B, BA [auth 2], C, A, AA [auth 1], B, BA [auth 2], C, CA [auth 3], D, DA [auth 4], E, EA [auth 5], F, FA [auth 6], G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z	IPR016162	Aldehyde dehydrogenase, N-terminal	Homologous Superfamily
A, AA [auth 1], B, BA [auth 2], C, A, AA [auth 1], B, BA [auth 2], C, CA [auth 3], D, DA [auth 4], E, EA [auth 5], F, FA [auth 6], G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z	IPR016163	Aldehyde dehydrogenase, C-terminal	Homologous Superfamily
A, AA [auth 1], B, BA [auth 2], C, A, AA [auth 1], B, BA [auth 2], C, CA [auth 3], D, DA [auth 4], E, EA [auth 5], F, FA [auth 6], G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z	IPR016160	Aldehyde dehydrogenase, cysteine active site	Conserved Site