4V3E

The CIDRa domain from IT4var07 PfEMP1 bound to endothelial protein C receptor

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d4v3eb_	Alpha and beta proteins (a+b)	MHC antigen-recognition domain	MHC antigen-recognition domain	MHC antigen-recognition domain	Endothelial protein C receptor	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	MHC antigen-recognition domain	8041433	3000521	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF21807	e4v3eA2	A: beta meanders	X: Beta meander domain in PfEMP1 protein (From Topology)	H: Beta meander domain in PfEMP1 protein (From Topology)	T: Beta meander domain in PfEMP1 protein	F: PF21807	ECOD (1.6)
A	PF03011	e4v3eA1	A: alpha bundles	X: Duffy-binding-like domain, C-terminal subdomain (From Topology)	H: Duffy-binding-like domain, C-terminal subdomain (From Topology)	T: Duffy-binding-like domain, C-terminal subdomain	F: PF03011	ECOD (1.6)
B	PF16497	e4v3eB1	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: PF16497	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF16497	MHC-I family domain (MHC_I_3)	MHC-I family domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	IT4VAR07 CIDRA	-	-	-
B	ENDOTHELIAL PROTEIN C RECEPTOR	molecular transducer activity signaling receptor activity	multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding regulation of biological process negative regulation of coagulation negative regulation of biological process multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding regulation of biological process negative regulation of coagulation negative regulation of biological process regulation of multicellular organismal process negative regulation of multicellular organismal process regulation of coagulation	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle cell surface perinuclear region of cytoplasm cytoplasm cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR037055	MHC class I-like antigen recognition-like superfamily	Homologous Superfamily
B	IPR015669	Endothelial protein C receptor	Family
B	IPR011161	MHC class I-like antigen recognition-like	Domain
B	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: Q9UNN8	coronary artery disease ulcerative colitis Liver Cirrhosis, Experimental astrocytic tumor gastric carcinoma invasive ductal breast carcinoma melanoma pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor cystic fibrosis heart disease oligodendroglioma skin basal cell carcinoma vascular disease ductal breast carcinoma in situ coronary artery disease ulcerative colitis Liver Cirrhosis, Experimental astrocytic tumor gastric carcinoma invasive ductal breast carcinoma melanoma pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor cystic fibrosis heart disease oligodendroglioma skin basal cell carcinoma vascular disease ductal breast carcinoma in situ malignant mesothelioma ovarian cancer thrombotic disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.