4UY2

Crystal structure of the complex of the extracellular domain of human alpha9 nAChR with alpha-bungarotoxin.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4uy2a_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d4uy2b_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d4uy2c_	Small proteins	Snake toxin-like	Snake toxin-like	Snake venom toxins	Bungarotoxin	(Bungarus multicinctus ) [TaxId: 8616 ],	SCOPe (2.08)
D	d4uy2d_	Small proteins	Snake toxin-like	Snake toxin-like	Snake venom toxins	Bungarotoxin	(Bungarus multicinctus ) [TaxId: 8616 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02931	e4uy2A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: PF02931	ECOD (1.6)
B	PF02931	e4uy2B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: PF02931	ECOD (1.6)
C	PF21947	e4uy2C1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: PF21947	ECOD (1.6)
D	PF21947	e4uy2D1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: PF21947	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
B	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
C	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)
D	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02931	Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD)	Neurotransmitter-gated ion-channel ligand binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9	transmitter-gated monoatomic ion channel activity monoatomic cation transmembrane transporter activity molecular transducer activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential neurotransmitter receptor activity ligand-gated channel activity postsynaptic neurotransmitter receptor activity passive transmembrane transporter activity acetylcholine-gated monoatomic cation-selective channel activity transporter activity ligand-gated monoatomic cation channel activity gated channel activity signaling receptor activity transmitter-gated monoatomic ion channel activity monoatomic cation transmembrane transporter activity molecular transducer activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential neurotransmitter receptor activity ligand-gated channel activity postsynaptic neurotransmitter receptor activity passive transmembrane transporter activity acetylcholine-gated monoatomic cation-selective channel activity transporter activity ligand-gated monoatomic cation channel activity gated channel activity signaling receptor activity excitatory extracellular ligand-gated monoatomic ion channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity monoatomic cation channel activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential channel activity monoatomic ion transmembrane transporter activity transmitter-gated channel activity transmembrane transporter activity calcium channel activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity metal ion transmembrane transporter activity transmembrane signaling receptor activity	positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality response to auditory stimulus response to stimulus response to mechanical stimulus response to abiotic stimulus response to external stimulus multicellular organismal process detection of external stimulus system process nervous system process detection of mechanical stimulus involved in sensory perception of sound detection of mechanical stimulus involved in sensory perception positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality response to auditory stimulus response to stimulus response to mechanical stimulus response to abiotic stimulus response to external stimulus multicellular organismal process detection of external stimulus system process nervous system process detection of mechanical stimulus involved in sensory perception of sound detection of mechanical stimulus involved in sensory perception sensory perception of mechanical stimulus detection of abiotic stimulus detection of stimulus sensory perception detection of mechanical stimulus detection of stimulus involved in sensory perception sensory perception of sound developmental process ear morphogenesis embryonic organ morphogenesis ear development sensory organ development animal organ development embryonic morphogenesis embryo development multicellular organism development anatomical structure morphogenesis sensory organ morphogenesis inner ear development inner ear morphogenesis anatomical structure development animal organ morphogenesis embryonic organ development membrane depolarization regulation of membrane potential	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane protein-containing complex plasma membrane protein complex membrane protein complex transporter complex cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane protein-containing complex plasma membrane protein complex membrane protein complex transporter complex receptor complex acetylcholine-gated channel complex transmembrane transporter complex plasma membrane signaling receptor complex monoatomic ion channel complex cell projection neuron projection plasma membrane bounded cell projection
C, D	ALPHA-BUNGAROTOXIN ISOFORM V31	channel regulator activity ion channel regulator activity molecular function regulator activity transporter regulator activity neurotransmitter receptor regulator activity acetylcholine receptor regulator activity molecular function inhibitor activity acetylcholine receptor inhibitor activity signaling receptor inhibitor activity signaling receptor regulator activity toxin activity	-	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR018000	Neurotransmitter-gated ion-channel, conserved site	Conserved Site
A, B	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
A, B	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
A, B	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
A, B	IPR002394	Nicotinic acetylcholine receptor	Family
A, B	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain	Domain
A, B	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
A, B	IPR006201	Neurotransmitter-gated ion-channel	Family
C, D	IPR018354	Snake toxin, conserved site	Conserved Site
C, D	IPR045860	Snake toxin-like superfamily	Homologous Superfamily
C, D	IPR003571	Snake three-finger toxin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9UGM1	atypical teratoid rhabdoid tumor glioblastoma malignant glioma Cell Transformation, Neoplastic Graves disease psoriasis cutaneous lupus erythematosus Hashimoto thyroiditis vitiligo

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.