4UUY

Structural Identification of the Vps18 beta-propeller reveals a critical role in the HOPS complex stability and function.

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Pep3/Vps18 beta-propeller domain-like	8046871	4005339	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Clathrin heavy-chain terminal domain-like	8103702	3001710	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Clathrin heavy-chain terminal domain-like	8103702	3001710	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF05131	e4uuyA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF05131	ECOD (1.6)
B	PF05131	e4uuyB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF05131	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF05131	Pep3/Vps18/deep orange beta-propeller domain (Pep3_Vps18)	Pep3/Vps18/deep orange beta-propeller domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	VACUOLAR MEMBRANE PROTEIN PEP3	cation binding ion binding binding metal ion binding small molecule binding protein-macromolecule adaptor activity molecular adaptor activity	protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process intracellular protein transport late endosome to vacuole transport vacuolar transport vesicle-mediated transport regulation of biological process regulation of cellular component organization regulation of cellular process vacuole organization biological regulation regulation of vacuole organization regulation of organelle organization cellular component organization organelle fusion organelle organization vacuole fusion vacuole fusion, non-autophagic regulation of vacuole fusion, non-autophagic cellular component organization or biogenesis vesicle localization establishment of organelle localization establishment of vesicle localization vesicle targeting organelle localization vesicle tethering secretion export from cell membrane docking organelle localization by membrane tethering secretion by cell exocytosis vesicle docking exocytic process vesicle docking involved in exocytosis membrane fusion organelle membrane fusion cellular component biogenesis vesicle organization regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly SNARE complex assembly membrane organization protein-containing complex organization regulation of cellular component biogenesis regulation of SNARE complex assembly vesicle fusion Golgi to endosome transport post-Golgi vesicle-mediated transport cytosolic transport Golgi vesicle transport endosome organization endomembrane system organization	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle cytoplasm organelle membrane fungal-type vacuole membrane protein-containing complex CORVET complex endosome intracellular vesicle endomembrane system vesicle tethering complex cytoplasmic vesicle vesicle membrane protein complex HOPS complex endosome membrane early endosome early endosome membrane cytoplasmic vesicle membrane vesicle membrane cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000547	Clathrin, heavy chain/VPS, 7-fold repeat	Repeat
A, B	IPR007810	Pep3/Vps18/deep orange, beta-propeller domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.