Annotations: 4UI8

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PARP	e4ui8A1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: PARP	ECOD (1.6)
B	PARP	e4ui8B1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: PARP	ECOD (1.6)
D	PARP	e4ui8D1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: PARP	ECOD (1.6)
C	PARP	e4ui8C1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: PARP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.228.10	Alpha Beta	Alpha-Beta Complex	Phosphoenolpyruvate Carboxykinase	domain 3	CATH (4.3.0)
B	3.90.228.10	Alpha Beta	Alpha-Beta Complex	Phosphoenolpyruvate Carboxykinase	domain 3	CATH (4.3.0)
D	6.20.320.10	Special	Other non-globular	YefM-like fold		CATH (4.3.0)
C	6.20.320.10	Special	Other non-globular	YefM-like fold		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00644	Poly(ADP-ribose) polymerase catalytic domain (PARP)	Poly(ADP-ribose) polymerase catalytic domain	-	Family
C, D	PF00644	Poly(ADP-ribose) polymerase catalytic domain (PARP)	Poly(ADP-ribose) polymerase catalytic domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	TANKYRASE-2	NAD+ ADP-ribosyltransferase activity pentosyltransferase activity glycosyltransferase activity transferase activity catalytic activity catalytic activity, acting on a protein NAD+-protein ADP-ribosyltransferase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups protein binding binding enzyme binding cation binding ion binding NAD+ ADP-ribosyltransferase activity pentosyltransferase activity glycosyltransferase activity transferase activity catalytic activity catalytic activity, acting on a protein NAD+-protein ADP-ribosyltransferase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups protein binding binding enzyme binding cation binding ion binding metal ion binding small molecule binding	organonitrogen compound metabolic process protein polyubiquitination primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of organelle organization organonitrogen compound metabolic process protein polyubiquitination primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of organelle organization regulation of cellular process telomere organization regulation of DNA biosynthetic process positive regulation of macromolecule biosynthetic process RNA-templated DNA biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process telomere maintenance via telomere lengthening positive regulation of metabolic process organic substance biosynthetic process positive regulation of telomere maintenance via telomere lengthening positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process cellular metabolic process regulation of cellular metabolic process DNA metabolic process regulation of chromosome organization regulation of telomere maintenance via telomere lengthening regulation of organelle organization positive regulation of chromosome organization telomere maintenance organic cyclic compound metabolic process biosynthetic process positive regulation of DNA metabolic process positive regulation of telomere maintenance via telomerase organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process DNA biosynthetic process regulation of metabolic process regulation of DNA metabolic process regulation of telomere maintenance regulation of cellular component organization positive regulation of cellular component organization cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process cellular component organization nucleic acid biosynthetic process positive regulation of biosynthetic process cellular component organization or biogenesis positive regulation of cellular process regulation of biosynthetic process telomere maintenance via telomerase biological regulation chromosome organization positive regulation of DNA biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulation of telomere maintenance via telomerase regulation of cellular biosynthetic process organelle organization cellular process positive regulation of cellular biosynthetic process protein localization localization cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to chromosome, telomeric region negative regulation of telomere maintenance negative regulation of telomere maintenance via telomere lengthening negative regulation of biological process negative regulation of chromosome organization negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of cellular component organization negative regulation of metabolic process negative regulation of organelle organization negative regulation of DNA metabolic process cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell communication signal transduction Wnt signaling pathway positive regulation of cell communication positive regulation of signal transduction regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway regulation of signal transduction positive regulation of response to stimulus positive regulation of Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of signaling regulation of Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling protein poly-ADP-ribosylation positive regulation of telomere capping telomere capping regulation of telomere capping protein auto-ADP-ribosylation	membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol Golgi membrane Golgi apparatus membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol Golgi membrane Golgi apparatus membrane bounding membrane of organelle organelle membrane pericentriolar material centrosome microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle perinuclear region of cytoplasm chromosome chromosome, telomeric region chromosomal region
C, D	TANKYRASE-2	NAD+ ADP-ribosyltransferase activity pentosyltransferase activity glycosyltransferase activity transferase activity catalytic activity catalytic activity, acting on a protein NAD+-protein ADP-ribosyltransferase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups protein binding binding enzyme binding cation binding ion binding NAD+ ADP-ribosyltransferase activity pentosyltransferase activity glycosyltransferase activity transferase activity catalytic activity catalytic activity, acting on a protein NAD+-protein ADP-ribosyltransferase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups protein binding binding enzyme binding cation binding ion binding metal ion binding small molecule binding	organonitrogen compound metabolic process protein polyubiquitination primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of organelle organization organonitrogen compound metabolic process protein polyubiquitination primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of organelle organization regulation of cellular process telomere organization regulation of DNA biosynthetic process positive regulation of macromolecule biosynthetic process RNA-templated DNA biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process telomere maintenance via telomere lengthening positive regulation of metabolic process organic substance biosynthetic process positive regulation of telomere maintenance via telomere lengthening positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process cellular metabolic process regulation of cellular metabolic process DNA metabolic process regulation of chromosome organization regulation of telomere maintenance via telomere lengthening regulation of organelle organization positive regulation of chromosome organization telomere maintenance organic cyclic compound metabolic process biosynthetic process positive regulation of DNA metabolic process positive regulation of telomere maintenance via telomerase organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process DNA biosynthetic process regulation of metabolic process regulation of DNA metabolic process regulation of telomere maintenance regulation of cellular component organization positive regulation of cellular component organization cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process cellular component organization nucleic acid biosynthetic process positive regulation of biosynthetic process cellular component organization or biogenesis positive regulation of cellular process regulation of biosynthetic process telomere maintenance via telomerase biological regulation chromosome organization positive regulation of DNA biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulation of telomere maintenance via telomerase regulation of cellular biosynthetic process organelle organization cellular process positive regulation of cellular biosynthetic process protein localization localization cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to chromosome, telomeric region negative regulation of telomere maintenance negative regulation of telomere maintenance via telomere lengthening negative regulation of biological process negative regulation of chromosome organization negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of cellular component organization negative regulation of metabolic process negative regulation of organelle organization negative regulation of DNA metabolic process cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell communication signal transduction Wnt signaling pathway positive regulation of cell communication positive regulation of signal transduction regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway regulation of signal transduction positive regulation of response to stimulus positive regulation of Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of signaling regulation of Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling protein poly-ADP-ribosylation positive regulation of telomere capping telomere capping regulation of telomere capping protein auto-ADP-ribosylation	membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol Golgi membrane Golgi apparatus membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol Golgi membrane Golgi apparatus membrane bounding membrane of organelle organelle membrane pericentriolar material centrosome microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle perinuclear region of cytoplasm chromosome chromosome, telomeric region chromosomal region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A, B	IPR012317	Poly(ADP-ribose) polymerase, catalytic domain	Domain
A, B	IPR002110	Ankyrin repeat	Repeat
A, B	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
A, B	IPR001660	Sterile alpha motif domain	Domain
C, D	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
C, D	IPR012317	Poly(ADP-ribose) polymerase, catalytic domain	Domain
C, D	IPR002110	Ankyrin repeat	Repeat
C, D	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
C, D	IPR001660	Sterile alpha motif domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9H2K2	ovarian cancer acute myeloid leukemia exocrine pancreatic carcinoma intellectual disability malignant glioma mast cell leukemia aggressive systemic mastocytosis Hormone refractory prostate cancer interstitial lung disease malignant pancreatic neoplasm medulloblastoma ovarian epithelial tumor atypical teratoid rhabdoid tumor large cell medulloblastoma osteosarcoma
C, D	Pharos: Q9H2K2	ovarian cancer acute myeloid leukemia exocrine pancreatic carcinoma intellectual disability malignant glioma mast cell leukemia aggressive systemic mastocytosis Hormone refractory prostate cancer interstitial lung disease malignant pancreatic neoplasm medulloblastoma ovarian epithelial tumor atypical teratoid rhabdoid tumor large cell medulloblastoma osteosarcoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.