4UAM

1.8 Angstrom crystal structure of IMP-1 metallo-beta-lactamase with a mixed iron-zinc center in the active site

External Resource: Annotation


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad4uama_ Alpha and beta proteins (a+b) Metallo-hydrolase/oxidoreductase Metallo-hydrolase/oxidoreductase Zn metallo-beta-lactamase Zn metallo-beta-lactamase (Pseudomonas aeruginosa NCGM2.S1 ) [TaxId: 1089456 ], SCOPe (2.08)
Bd4uamb_ Alpha and beta proteins (a+b) Metallo-hydrolase/oxidoreductase Metallo-hydrolase/oxidoreductase Zn metallo-beta-lactamase Zn metallo-beta-lactamase (Pseudomonas aeruginosa NCGM2.S1 ) [TaxId: 1089456 ], SCOPe (2.08)
Cd4uamc_ Alpha and beta proteins (a+b) Metallo-hydrolase/oxidoreductase Metallo-hydrolase/oxidoreductase Zn metallo-beta-lactamase Zn metallo-beta-lactamase (Pseudomonas aeruginosa NCGM2.S1 ) [TaxId: 1089456 ], SCOPe (2.08)
Dd4uamd_ Alpha and beta proteins (a+b) Metallo-hydrolase/oxidoreductase Metallo-hydrolase/oxidoreductase Zn metallo-beta-lactamase Zn metallo-beta-lactamase (Pseudomonas aeruginosa NCGM2.S1 ) [TaxId: 1089456 ], SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ALactamase_B_6_1e4uamA1 A: a+b four layersX: Metallo-hydrolase/oxidoreductase (From Topology)H: Metallo-hydrolase/oxidoreductase (From Topology)T: Metallo-hydrolase/oxidoreductaseF: Lactamase_B_6_1ECOD (1.6)
BLactamase_B_6_1e4uamB1 A: a+b four layersX: Metallo-hydrolase/oxidoreductase (From Topology)H: Metallo-hydrolase/oxidoreductase (From Topology)T: Metallo-hydrolase/oxidoreductaseF: Lactamase_B_6_1ECOD (1.6)
CLactamase_B_6_1e4uamC1 A: a+b four layersX: Metallo-hydrolase/oxidoreductase (From Topology)H: Metallo-hydrolase/oxidoreductase (From Topology)T: Metallo-hydrolase/oxidoreductaseF: Lactamase_B_6_1ECOD (1.6)
DLactamase_B_6_1e4uamD1 A: a+b four layersX: Metallo-hydrolase/oxidoreductase (From Topology)H: Metallo-hydrolase/oxidoreductase (From Topology)T: Metallo-hydrolase/oxidoreductaseF: Lactamase_B_6_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.60.15.10 Alpha Beta 4-Layer Sandwich Metallo-beta-lactamase Chain ACATH (4.3.0)
B3.60.15.10 Alpha Beta 4-Layer Sandwich Metallo-beta-lactamase Chain ACATH (4.3.0)
C3.60.15.10 Alpha Beta 4-Layer Sandwich Metallo-beta-lactamase Chain ACATH (4.3.0)
D3.60.15.10 Alpha Beta 4-Layer Sandwich Metallo-beta-lactamase Chain ACATH (4.3.0)

AMR Gene: CARD Annotation CARD Database Homepage

ChainsAccessionShort NameDescriptionProvenance Source (Version)
A, B, C, D
ARO:3002192IMP-1IMP-1 is a beta-lactamase found in Serratia marcescens.CARD (3.2.9)

AMR Gene Family: CARD Annotation CARD Database Homepage

ChainsAccessionGene FamilyDrug Class Resistance MachanismProvenance Source (Version)
A, B, C, D
ARO:3000020IMP beta-lactamasecarbapenem, cephalosporin, cephamycin, penam, penemantibiotic inactivationCARD (3.2.9)

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
A, B, C, D
CSD Parent Component: CYS

RESID:  AA0262

PSI-MOD :  L-cysteine sulfinic acid MOD:00267