Annotations: 4TZL

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	HORMA	e4tzlA1	A: a+b two layers	X: The spindle assembly checkpoint protein mad2 (From Topology)	H: The spindle assembly checkpoint protein mad2 (From Topology)	T: The spindle assembly checkpoint protein mad2	F: HORMA	ECOD (1.6)
B	HORMA	e4tzlB1	A: a+b two layers	X: The spindle assembly checkpoint protein mad2 (From Topology)	H: The spindle assembly checkpoint protein mad2 (From Topology)	T: The spindle assembly checkpoint protein mad2	F: HORMA	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.900.10	Alpha Beta	2-Layer Sandwich	Cell Cycle, Spindle Assembly Checkpoint Protein	Chain A	CATH (4.3.0)
B	3.30.900.10	Alpha Beta	2-Layer Sandwich	Cell Cycle, Spindle Assembly Checkpoint Protein	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02301	HORMA domain (HORMA)	HORMA domain	The HORMA (for Hop1p, Rev7p and MAD2) domain has been suggested to recognise chromatin states that result from DNA adducts, double stranded breaks or non-attachment to the spindle and acts as an adaptor that recruits other proteins. MAD2 is a spindle ...	The HORMA (for Hop1p, Rev7p and MAD2) domain has been suggested to recognise chromatin states that result from DNA adducts, double stranded breaks or non-attachment to the spindle and acts as an adaptor that recruits other proteins. MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Protein HTP-2	-	meiotic chromosome segregation sexual reproduction reproductive process meiotic cell cycle organelle fission meiotic cell cycle process cellular component organization nuclear division organelle organization nuclear chromosome segregation cellular process meiotic nuclear division cell cycle cellular component organization or biogenesis meiotic chromosome segregation sexual reproduction reproductive process meiotic cell cycle organelle fission meiotic cell cycle process cellular component organization nuclear division organelle organization nuclear chromosome segregation cellular process meiotic nuclear division cell cycle cellular component organization or biogenesis chromosome segregation cell cycle process chromosome organization chromosome organization involved in meiotic cell cycle meiosis I meiosis I cell cycle process homologous chromosome pairing at meiosis homologous chromosome segregation regulation of biological process microtubule organizing center organization regulation of cellular process regulation of cell cycle process microtubule cytoskeleton organization biological regulation centriole-centriole cohesion centrosome cycle microtubule-based process regulation of cell cycle regulation of centriole-centriole cohesion cytoskeleton organization homologous recombination nucleobase-containing compound metabolic process organic substance metabolic process reciprocal homologous recombination DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process reciprocal meiotic recombination organic cyclic compound metabolic process metabolic process macromolecule metabolic process	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle condensed nuclear chromosome nucleus membrane-enclosed lumen nuclear chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle condensed nuclear chromosome nucleus membrane-enclosed lumen nuclear chromosome intracellular membrane-bounded organelle intracellular organelle lumen organelle lumen synaptonemal structure synaptonemal complex condensed chromosome nuclear lumen lateral element
C, D	C. elegans HIM-3 closure motif	DNA binding binding organic cyclic compound binding nucleic acid binding	homologous recombination sexual reproduction reproductive process meiotic cell cycle process nucleobase-containing compound metabolic process cellular component organization organic substance metabolic process meiosis I meiotic nuclear division cell cycle cellular component organization or biogenesis reciprocal homologous recombination cell cycle process DNA recombination homologous recombination sexual reproduction reproductive process meiotic cell cycle process nucleobase-containing compound metabolic process cellular component organization organic substance metabolic process meiosis I meiotic nuclear division cell cycle cellular component organization or biogenesis reciprocal homologous recombination cell cycle process DNA recombination meiotic cell cycle organelle fission primary metabolic process DNA metabolic process nucleic acid metabolic process reciprocal meiotic recombination organic cyclic compound metabolic process nuclear division organelle organization meiosis I cell cycle process metabolic process cellular process macromolecule metabolic process meiotic chromosome segregation synaptonemal complex assembly cellular component biogenesis cellular component assembly synaptonemal complex organization chromosome segregation chromosome organization chromosome organization involved in meiotic cell cycle homologous chromosome pairing at meiosis nuclear chromosome segregation homologous chromosome segregation sister chromatid cohesion regulation of biological process microtubule organizing center organization regulation of cellular process regulation of cell cycle process microtubule cytoskeleton organization biological regulation centriole-centriole cohesion centrosome cycle microtubule-based process regulation of cell cycle regulation of centriole-centriole cohesion cytoskeleton organization	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle condensed nuclear chromosome nucleus membrane-enclosed lumen nuclear chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle condensed nuclear chromosome nucleus membrane-enclosed lumen nuclear chromosome intracellular membrane-bounded organelle intracellular organelle lumen organelle lumen condensed chromosome nuclear lumen synaptonemal structure synaptonemal complex lateral element

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036570	HORMA domain superfamily	Homologous Superfamily
A, B	IPR003511	HORMA domain	Domain
C, D	IPR036570	HORMA domain superfamily	Homologous Superfamily
C, D	IPR003511	HORMA domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.