4TSZ

Crystal structure of DNA polymerase sliding clamp from Pseudomonas aeruginosa with ligand

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
G [auth D]	PF00712	e4tszD1	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF00712	ECOD (1.6)
G [auth D]	PF02767	e4tszD2	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02767	ECOD (1.6)
G [auth D]	PF02768	e4tszD3	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02768	ECOD (1.6)
O [auth H]	PF00712	e4tszH1	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF00712	ECOD (1.6)
O [auth H]	PF02767	e4tszH2	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02767	ECOD (1.6)
O [auth H]	PF02768	e4tszH3	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02768	ECOD (1.6)
S [auth J]	PF00712	e4tszJ1	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF00712	ECOD (1.6)
S [auth J]	PF02767	e4tszJ2	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02767	ECOD (1.6)
S [auth J]	PF02768	e4tszJ3	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02768	ECOD (1.6)
U [auth K]	PF00712	e4tszK1	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF00712	ECOD (1.6)
U [auth K]	PF02767	e4tszK2	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02767	ECOD (1.6)
U [auth K]	PF02768	e4tszK3	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02768	ECOD (1.6)
A	PF00712	e4tszA1	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF00712	ECOD (1.6)
A	PF02767	e4tszA2	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02767	ECOD (1.6)
A	PF02768	e4tszA3	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02768	ECOD (1.6)
AA [auth N]	PF00712	e4tszN1	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF00712	ECOD (1.6)
AA [auth N]	PF02767	e4tszN2	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02767	ECOD (1.6)
AA [auth N]	PF02768	e4tszN3	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02768	ECOD (1.6)
C [auth B]	PF00712	e4tszB1	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF00712	ECOD (1.6)
C [auth B]	PF02767	e4tszB2	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02767	ECOD (1.6)
C [auth B]	PF02768	e4tszB3	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02768	ECOD (1.6)
CA [auth O]	PF00712	e4tszO1	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF00712	ECOD (1.6)
CA [auth O]	PF02767	e4tszO2	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02767	ECOD (1.6)
CA [auth O]	PF02768	e4tszO3	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02768	ECOD (1.6)
E [auth C]	PF00712	e4tszC1	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF00712	ECOD (1.6)
E [auth C]	PF02767	e4tszC2	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02767	ECOD (1.6)
E [auth C]	PF02768	e4tszC3	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02768	ECOD (1.6)
EA [auth P]	PF00712	e4tszP1	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF00712	ECOD (1.6)
EA [auth P]	PF02767	e4tszP2	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02767	ECOD (1.6)
EA [auth P]	PF02768	e4tszP3	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02768	ECOD (1.6)
I [auth E]	PF00712	e4tszE1	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF00712	ECOD (1.6)
I [auth E]	PF02767	e4tszE2	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02767	ECOD (1.6)
I [auth E]	PF02768	e4tszE3	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02768	ECOD (1.6)
K [auth F]	PF00712	e4tszF1	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF00712	ECOD (1.6)
K [auth F]	PF02767	e4tszF2	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02767	ECOD (1.6)
K [auth F]	PF02768	e4tszF3	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02768	ECOD (1.6)
M [auth G]	PF00712	e4tszG1	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF00712	ECOD (1.6)
M [auth G]	PF02767	e4tszG2	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02767	ECOD (1.6)
M [auth G]	PF02768	e4tszG3	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02768	ECOD (1.6)
Q [auth I]	PF00712	e4tszI1	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF00712	ECOD (1.6)
Q [auth I]	PF02767	e4tszI2	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02767	ECOD (1.6)
Q [auth I]	PF02768	e4tszI3	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02768	ECOD (1.6)
W [auth L]	PF00712	e4tszL1	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF00712	ECOD (1.6)
W [auth L]	PF02767	e4tszL2	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02767	ECOD (1.6)
W [auth L]	PF02768	e4tszL3	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02768	ECOD (1.6)
Y [auth M]	PF00712	e4tszM1	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF00712	ECOD (1.6)
Y [auth M]	PF02767	e4tszM2	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02767	ECOD (1.6)
Y [auth M]	PF02768	e4tszM3	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: PF02768	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
G [auth D]	3.10.150.10	Alpha Beta	Roll	DNA Polymerase III	Chain A, domain 2	CATH (4.3.0)
O [auth H]	3.10.150.10	Alpha Beta	Roll	DNA Polymerase III	Chain A, domain 2	CATH (4.3.0)
S [auth J]	3.10.150.10	Alpha Beta	Roll	DNA Polymerase III	Chain A, domain 2	CATH (4.3.0)
U [auth K]	3.10.150.10	Alpha Beta	Roll	DNA Polymerase III	Chain A, domain 2	CATH (4.3.0)
A	3.10.150.10	Alpha Beta	Roll	DNA Polymerase III	Chain A, domain 2	CATH (4.3.0)
AA [auth N]	3.10.150.10	Alpha Beta	Roll	DNA Polymerase III	Chain A, domain 2	CATH (4.3.0)
C [auth B]	3.10.150.10	Alpha Beta	Roll	DNA Polymerase III	Chain A, domain 2	CATH (4.3.0)
CA [auth O]	3.10.150.10	Alpha Beta	Roll	DNA Polymerase III	Chain A, domain 2	CATH (4.3.0)
E [auth C]	3.10.150.10	Alpha Beta	Roll	DNA Polymerase III	Chain A, domain 2	CATH (4.3.0)
EA [auth P]	3.10.150.10	Alpha Beta	Roll	DNA Polymerase III	Chain A, domain 2	CATH (4.3.0)
I [auth E]	3.10.150.10	Alpha Beta	Roll	DNA Polymerase III	Chain A, domain 2	CATH (4.3.0)
K [auth F]	3.10.150.10	Alpha Beta	Roll	DNA Polymerase III	Chain A, domain 2	CATH (4.3.0)
M [auth G]	3.10.150.10	Alpha Beta	Roll	DNA Polymerase III	Chain A, domain 2	CATH (4.3.0)
Q [auth I]	3.10.150.10	Alpha Beta	Roll	DNA Polymerase III	Chain A, domain 2	CATH (4.3.0)
W [auth L]	3.10.150.10	Alpha Beta	Roll	DNA Polymerase III	Chain A, domain 2	CATH (4.3.0)
Y [auth M]	3.10.150.10	Alpha Beta	Roll	DNA Polymerase III	Chain A, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, AA [auth N], C [auth B], CA [auth O], E [auth C], A, AA [auth N], C [auth B], CA [auth O], E [auth C], EA [auth P], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I], S [auth J], U [auth K], W [auth L], Y [auth M]	PF02768	DNA polymerase III beta subunit, C-terminal domain (DNA_pol3_beta_3)	DNA polymerase III beta subunit, C-terminal domain	A dimer of the beta subunit of DNA polymerase beta forms a ring which encircles duplex DNA. Each monomer contains three domains of identical topology and DNA clamp fold.	Domain
A, AA [auth N], C [auth B], CA [auth O], E [auth C], A, AA [auth N], C [auth B], CA [auth O], E [auth C], EA [auth P], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I], S [auth J], U [auth K], W [auth L], Y [auth M]	PF02767	DNA polymerase III beta subunit, central domain (DNA_pol3_beta_2)	DNA polymerase III beta subunit, central domain	A dimer of the beta subunit of DNA polymerase beta forms a ring which encircles duplex DNA. Each monomer contains three domains of identical topology and DNA clamp fold.	Domain
A, AA [auth N], C [auth B], CA [auth O], E [auth C], A, AA [auth N], C [auth B], CA [auth O], E [auth C], EA [auth P], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I], S [auth J], U [auth K], W [auth L], Y [auth M]	PF00712	DNA polymerase III beta subunit, N-terminal domain (DNA_pol3_beta)	DNA polymerase III beta subunit, N-terminal domain	A dimer of the beta subunit of DNA polymerase beta forms a ring which encircles duplex DNA. Each monomer contains three domains of identical topology and DNA clamp fold.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, AA [auth N], C [auth B], CA [auth O], E [auth C], A, AA [auth N], C [auth B], CA [auth O], E [auth C], EA [auth P], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I], S [auth J], U [auth K], W [auth L], Y [auth M]	DNA polymerase III subunit beta	catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity catalytic activity, acting on a nucleic acid transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups DNA binding binding organic cyclic compound binding nucleic acid binding nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity catalytic activity, acting on a nucleic acid transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups DNA binding binding organic cyclic compound binding nucleic acid binding nuclease activity hydrolase activity, acting on ester bonds 3'-5' exonuclease activity hydrolase activity exonuclease activity	DNA-templated DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA strand elongation organic substance metabolic process DNA replication metabolic process DNA strand elongation involved in DNA replication macromolecule metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity transferase complex, transferring phosphorus-containing groups DNA polymerase III complex protein-containing complex catalytic complex transferase complex DNA polymerase complex intracellular protein-containing complex
B [auth Q], BA [auth 4], D [auth R], DA [auth 5], F [auth S], B [auth Q], BA [auth 4], D [auth R], DA [auth 5], F [auth S], FA [auth 6], H [auth T], J [auth U], L [auth V], N [auth X], P [auth Y], R [auth Z], T [auth 0], V [auth 1], X [auth 2], Z [auth 3]	ACE-GLN-ALC-ASP-LEU-ZCL peptide	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, AA [auth N], C [auth B], CA [auth O], E [auth C], A, AA [auth N], C [auth B], CA [auth O], E [auth C], EA [auth P], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I], S [auth J], U [auth K], W [auth L], Y [auth M]	IPR046938	DNA clamp superfamily	Homologous Superfamily
A, AA [auth N], C [auth B], CA [auth O], E [auth C], A, AA [auth N], C [auth B], CA [auth O], E [auth C], EA [auth P], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I], S [auth J], U [auth K], W [auth L], Y [auth M]	IPR022637	DNA polymerase III, beta sliding clamp, central	Domain
A, AA [auth N], C [auth B], CA [auth O], E [auth C], A, AA [auth N], C [auth B], CA [auth O], E [auth C], EA [auth P], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I], S [auth J], U [auth K], W [auth L], Y [auth M]	IPR001001	DNA polymerase III, beta sliding clamp	Family
A, AA [auth N], C [auth B], CA [auth O], E [auth C], A, AA [auth N], C [auth B], CA [auth O], E [auth C], EA [auth P], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I], S [auth J], U [auth K], W [auth L], Y [auth M]	IPR022634	DNA polymerase III, beta sliding clamp, N-terminal	Domain
A, AA [auth N], C [auth B], CA [auth O], E [auth C], A, AA [auth N], C [auth B], CA [auth O], E [auth C], EA [auth P], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I], S [auth J], U [auth K], W [auth L], Y [auth M]	IPR022635	DNA polymerase III, beta sliding clamp, C-terminal	Domain

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B [auth Q], BA [auth 4], D [auth R], DA [auth 5], F [auth S], B [auth Q], BA [auth 4], D [auth R], DA [auth 5], F [auth S], FA [auth 6], H [auth T], J [auth U], L [auth V], N [auth X], P [auth Y], R [auth Z], T [auth 0], V [auth 1], X [auth 2], Z [auth 3]	ACE	RESID: AA0041 , AA0042 , AA0043 , AA0044 , AA0045 , AA0046 , AA0049 , AA0050 , AA0051 , AA0052 , AA0053 , AA0054 , AA0354 PSI-MOD : N-acetyl-L-alanine MOD:00050 , N-acetyl-L-aspartic acid MOD:00051 , N-acetyl-L-cysteine MOD:00052 , N-acetyl-S-archeol-cysteine MOD:00897 , N-acetyl-L-glutamic acid MOD:00053 , N-acetyl-L-glutamine MOD:00054 , N-acetylglycine MOD:00055 , N-acetyl-L-methionine MOD:00058 , N-acetyl-L-proline MOD:00059 , N-acetyl-L-serine MOD:00060 , N,O-diacetylated L-serine MOD:00648 , N-acetyl-L-threonine MOD:00061 , N-acetyl-L-tyrosine MOD:00062 , N-acetyl-L-valine MOD:00063 , N2-acetyl-L-arginine MOD:00359
B [auth Q], BA [auth 4], D [auth R], DA [auth 5], F [auth S], B [auth Q], BA [auth 4], D [auth R], DA [auth 5], F [auth S], FA [auth 6], H [auth T], J [auth U], L [auth V], N [auth X], P [auth Y], R [auth Z], T [auth 0], V [auth 1], X [auth 2], Z [auth 3]	ALC	Parent Component: ALA RESID: AA0041 , AA0042 , AA0043 , AA0044 , AA0045 , AA0046 , AA0049 , AA0050 , AA0051 , AA0052 , AA0053 , AA0054 , AA0354
B [auth Q], BA [auth 4], D [auth R], DA [auth 5], F [auth S], B [auth Q], BA [auth 4], D [auth R], DA [auth 5], F [auth S], FA [auth 6], H [auth T], J [auth U], L [auth V], N [auth X], P [auth Y], R [auth Z], T [auth 0], V [auth 1], X [auth 2], Z [auth 3]	ZCL	Parent Component: PHE RESID: AA0041 , AA0042 , AA0043 , AA0044 , AA0045 , AA0046 , AA0049 , AA0050 , AA0051 , AA0052 , AA0053 , AA0054 , AA0354

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4TSZ

Crystal structure of DNA polymerase sliding clamp from Pseudomonas aeruginosa with ligand

External Resource: Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage

Protein Modification Annotation