4TPG

Selectivity mechanism of a bacterial homologue of the human drug peptide transporters PepT1 and PepT2

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00854	e4tpgA2	A: alpha complex topology	X: Major facilitator superfamily (MFS) general substrate transporter (From Topology)	H: Major facilitator superfamily (MFS) general substrate transporter (From Topology)	T: Major facilitator superfamily (MFS) general substrate transporter	F: PF00854	ECOD (1.6)
B	PF00854	e4tpgB2	A: alpha complex topology	X: Major facilitator superfamily (MFS) general substrate transporter (From Topology)	H: Major facilitator superfamily (MFS) general substrate transporter (From Topology)	T: Major facilitator superfamily (MFS) general substrate transporter	F: PF00854	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1250.20	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)
B	1.20.1250.20	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00854	POT family (PTR2)	POT family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Proton:oligopeptide symporter POT family	dipeptide transmembrane transporter activity oligopeptide transmembrane transporter activity amide transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity solute:monoatomic cation symporter activity peptide transmembrane transporter activity peptide:proton symporter activity secondary active transmembrane transporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity dipeptide transmembrane transporter activity oligopeptide transmembrane transporter activity amide transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity solute:monoatomic cation symporter activity peptide transmembrane transporter activity peptide:proton symporter activity secondary active transmembrane transporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity solute:proton symporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity symporter activity tripeptide transmembrane transporter activity identical protein binding protein binding binding	nitrogen compound transport transport oligopeptide transport organic substance transport establishment of localization transmembrane transport oligopeptide transmembrane transport localization dipeptide transport amide transport cellular process dipeptide transmembrane transport	membrane cellular anatomical entity
C [auth E]	Ala-L-3-Br-Tyr-Ala	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000109	Proton-dependent oligopeptide transporter family	Family
A, B	IPR005279	Dipeptide/tripeptide permease	Family
A, B	IPR036259	MFS transporter superfamily	Homologous Superfamily

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Major Facilitator Superfamily (MFS) Transporters	PepT_So Oligopeptide-proton symporter (POT family) with bound AlaTyr(Br)

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.