Annotations: 4RU4

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF20745	e4ru4B3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Ig-like domain in tailspike protein (From Topology)	T: Ig-like domain in tailspike protein	F: PF20745	ECOD (1.6)
B	PF22442	e4ru4B1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Pectin lyase-like (From Topology)	T: Pectin lyase-like	F: PF22442	ECOD (1.6)
E	PF20745	e4ru4E2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Ig-like domain in tailspike protein (From Topology)	T: Ig-like domain in tailspike protein	F: PF20745	ECOD (1.6)
E	PF22442	e4ru4E1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Pectin lyase-like (From Topology)	T: Pectin lyase-like	F: PF22442	ECOD (1.6)
A	PF20745	e4ru4A2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Ig-like domain in tailspike protein (From Topology)	T: Ig-like domain in tailspike protein	F: PF20745	ECOD (1.6)
A	PF22442	e4ru4A3	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Pectin lyase-like (From Topology)	T: Pectin lyase-like	F: PF22442	ECOD (1.6)
C	PF20745	e4ru4C3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Ig-like domain in tailspike protein (From Topology)	T: Ig-like domain in tailspike protein	F: PF20745	ECOD (1.6)
C	PF22442	e4ru4C1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Pectin lyase-like (From Topology)	T: Pectin lyase-like	F: PF22442	ECOD (1.6)
D	PF20745	e4ru4D3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Ig-like domain in tailspike protein (From Topology)	T: Ig-like domain in tailspike protein	F: PF20745	ECOD (1.6)
D	PF22442	e4ru4D1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Pectin lyase-like (From Topology)	T: Pectin lyase-like	F: PF22442	ECOD (1.6)
F	PF20745	e4ru4F1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Ig-like domain in tailspike protein (From Topology)	T: Ig-like domain in tailspike protein	F: PF20745	ECOD (1.6)
F	PF22442	e4ru4F2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Pectin lyase-like (From Topology)	T: Pectin lyase-like	F: PF22442	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF13229	Right handed beta helix region (Beta_helix)	Right handed beta helix region	-	Repeat
A, B, C, D, E A, B, C, D, E, F	PF20745	Ig-like domain in tailspike protein (TSP_Ig-like)	Ig-like domain in tailspike protein	This domain is found in Tail spike protein (TSP) from Shigella phage Sf6 and similar sequences from tailed bacteriophages and bacterial prophages. It forms a beta-sandwich formed by two antiparallel, three stranded beta-sheets. A short alpha helix is ...	This domain is found in Tail spike protein (TSP) from Shigella phage Sf6 and similar sequences from tailed bacteriophages and bacterial prophages. It forms a beta-sandwich formed by two antiparallel, three stranded beta-sheets. A short alpha helix is included in the connecting loop between the third and fourth strand. This domain is structurally homologous to viral coat proteins [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	tail spike protein gp49	-	symbiont-mediated disruption of host anatomical structure biological process involved in interspecies interaction between organisms viral life cycle symbiont-mediated disruption of host cell envelope biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell via disruption of host cell envelope symbiont-mediated disruption of host cellular anatomical entity symbiont entry into host cell viral process symbiont entry into host disruption of anatomical structure in another organism symbiont entry into host cell via disruption of host cell glycocalyx	virus tail virion component

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR006626	Parallel beta-helix repeat	Repeat
A, B, C, D, E A, B, C, D, E, F	IPR012334	Pectin lyase fold	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR039448	Right handed beta helix domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR005604	Bacteriophage T7 tail fibre protein-like, N-terminal domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR049350	Tailspike protein-like, Ig-like domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR011050	Pectin lyase fold/virulence factor	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.