Annotations: 4RKK

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00686	e4rkkA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: PF00686	ECOD (1.6)
A	PF00782	e4rkkA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: (Phosphotyrosine protein) phosphatases II	F: PF00782	ECOD (1.6)
B [auth C]	PF00686	e4rkkC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: PF00686	ECOD (1.6)
B [auth C]	PF00782	e4rkkC1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: (Phosphotyrosine protein) phosphatases II	F: PF00782	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.190.10	Alpha Beta	Alpha-Beta Complex	Protein-Tyrosine Phosphatase	Chain A	CATH (4.3.0)
B [auth C]	3.90.190.10	Alpha Beta	Alpha-Beta Complex	Protein-Tyrosine Phosphatase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth C]	PF00782	Dual specificity phosphatase, catalytic domain (DSPc)	Dual specificity phosphatase, catalytic domain	Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a "recognition" region [2].	Domain
A, B [auth C]	PF00686	Starch binding domain (CBM_20)	Starch binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C]	Laforin	starch binding binding polysaccharide binding carbohydrate binding glycogen binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity UDP-glycosyltransferase activity starch binding binding polysaccharide binding carbohydrate binding glycogen binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity UDP-glycosyltransferase activity glycogen (starch) synthase activity glycosyltransferase activity transferase activity glucosyltransferase activity hexosyltransferase activity UDP-glucosyltransferase activity myosin phosphatase activity carbohydrate phosphatase activity protein binding protein dimerization activity protein tyrosine phosphatase activity identical protein binding protein homodimerization activity protein tyrosine/serine/threonine phosphatase activity	protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of cellular process nucleocytoplasmic transport regulation of protein localization transport nuclear transport regulation of protein localization to nucleus localization import into nucleus regulation of protein import into nucleus cellular macromolecule localization protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of cellular process nucleocytoplasmic transport regulation of protein localization transport nuclear transport regulation of protein localization to nucleus localization import into nucleus regulation of protein import into nucleus cellular macromolecule localization establishment of localization in cell protein import into nucleus regulation of intracellular transport regulation of biological process regulation of transport organic substance transport biological regulation regulation of establishment of protein localization intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus regulation of protein transport establishment of localization establishment of protein localization to organelle protein transport regulation of cellular localization macromolecule localization protein localization to organelle regulation of intracellular protein transport cellular process intracellular protein transport organic acid transmembrane transport organic anion transport carboxylic acid transmembrane transport carboxylic acid transport amino acid transmembrane transport L-amino acid transport L-glutamate import organic acid transport transmembrane transport amino acid transport acidic amino acid transport dicarboxylic acid transport L-alpha-amino acid transmembrane transport L-glutamate transmembrane transport negative regulation of hydrolase activity regulation of phosphatase activity regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity negative regulation of phosphate metabolic process negative regulation of cellular metabolic process negative regulation of phosphatase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of cellular process negative regulation of dephosphorylation phosphorus metabolic process regulation of dephosphorylation cellular metabolic process negative regulation of metabolic process dephosphorylation negative regulation of molecular function regulation of cellular metabolic process regulation of molecular function regulation of hydrolase activity negative regulation of phosphorus metabolic process regulation of phosphorus metabolic process metabolic process regulation of metabolic process protein dephosphorylation organonitrogen compound metabolic process primary metabolic process organic substance metabolic process macromolecule modification protein metabolic process macromolecule metabolic process protein modification process negative regulation of cell cycle cell cycle regulation of cell cycle behavior multicellular organismal process system process learning learning or memory nervous system process nonassociative learning cognition habituation regulation of growth regulation of cellular component organization growth regulation of cell growth cell growth cellular component organization cellular component organization or biogenesis carbohydrate phosphorylation carbohydrate metabolic process phosphorylation catabolic process proteolysis involved in protein catabolic process macromolecule catabolic process regulation of primary metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis proteolysis organonitrogen compound catabolic process regulation of protein metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process regulation of proteasomal protein catabolic process organic substance catabolic process regulation of protein catabolic process protein localization to cell periphery protein localization to plasma membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of protein localization to plasma membrane regulation of protein localization to membrane autophagosome assembly organelle assembly vacuole organization macroautophagy autophagy autophagosome organization cellular component biogenesis cellular catabolic process organelle organization cellular component assembly process utilizing autophagic mechanism regulation of protein modification process regulation of protein phosphorylation regulation of peptidyl-serine phosphorylation peptidyl-serine modification peptidyl-serine phosphorylation negative regulation of protein modification process peptidyl-amino acid modification negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of peptidyl-serine phosphorylation protein phosphorylation negative regulation of protein phosphorylation regulation of phosphorylation negative regulation of phosphorylation proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process positive regulation of biological process positive regulation of cellular metabolic process regulation of autophagy positive regulation of metabolic process positive regulation of macroautophagy positive regulation of cellular process positive regulation of autophagy positive regulation of catabolic process regulation of macroautophagy regulation of cellular catabolic process positive regulation of cellular catabolic process regulation of post-translational protein modification regulation of protein ubiquitination protein ubiquitination regulation of protein modification by small protein conjugation or removal post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal peptidyl-tyrosine dephosphorylation cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell communication signal transduction Wnt signaling pathway monoatomic ion transport monoatomic cation transport calcium ion transport metal ion transport cellular biosynthetic process organic substance biosynthetic process regulation of biosynthetic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process mitochondrion organization glucan biosynthetic process polysaccharide biosynthetic process energy derivation by oxidation of organic compounds carbohydrate biosynthetic process glycogen metabolic process generation of precursor metabolites and energy glycogen biosynthetic process polysaccharide metabolic process glucan metabolic process energy reserve metabolic process developmental process cell population proliferation cellular developmental process nervous system development neurogenesis multicellular organism development gliogenesis cell differentiation anatomical structure development glial cell proliferation system development	somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity intracellular anatomical structure cytoplasm cytosol cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection cell periphery somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity intracellular anatomical structure cytoplasm cytosol cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection cell periphery plasma membrane membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen organelle subcompartment cytoplasmic side of membrane endomembrane system side of membrane cytoplasmic side of rough endoplasmic reticulum membrane rough endoplasmic reticulum endoplasmic reticulum subcompartment bounding membrane of organelle rough endoplasmic reticulum membrane nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasmic side of endoplasmic reticulum membrane organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C]	IPR034831	Laforin, CBM20 domain	Domain
A, B [auth C]	IPR042942	Laforin	Family
A, B [auth C]	IPR000340	Dual specificity phosphatase, catalytic domain	Domain
A, B [auth C]	IPR016130	Protein-tyrosine phosphatase, active site	Active Site
A, B [auth C]	IPR013784	Carbohydrate-binding-like fold	Homologous Superfamily
A, B [auth C]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B [auth C]	IPR029021	Protein-tyrosine phosphatase-like	Homologous Superfamily
A, B [auth C]	IPR002044	Carbohydrate binding module family 20	Domain
A, B [auth C]	IPR000387	Tyrosine-specific protein phosphatases domain	Domain
A, B [auth C]	IPR045204	Laforin-like, dual specificity phosphatase domain	Domain
A, B [auth C]	IPR020422	Dual specificity protein phosphatase domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B [auth C]	Pharos: O95278	Lafora disease progressive myoclonus epilepsy dentatorubral-pallidoluysian atrophy glycogen storage disease epilepsy neurodegenerative disease psoriasis action myoclonus-renal failure syndrome Atypical Inclusion-Body Disease malignant colon neoplasm osteosarcoma atypical teratoid rhabdoid tumor inborn errors of metabolism attention deficit hyperactivity disorder, inattentive type glioblastoma Lafora disease progressive myoclonus epilepsy dentatorubral-pallidoluysian atrophy glycogen storage disease epilepsy neurodegenerative disease psoriasis action myoclonus-renal failure syndrome Atypical Inclusion-Body Disease malignant colon neoplasm osteosarcoma atypical teratoid rhabdoid tumor inborn errors of metabolism attention deficit hyperactivity disorder, inattentive type glioblastoma intellectual disability

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.