Annotations: 4RKH

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth C]	SCOP2B Superfamily	CXC domain-like	8091620	3002037	SCOP2B (2022-06-29)
B [auth D]	SCOP2B Superfamily	CXC domain-like	8091620	3002037	SCOP2B (2022-06-29)
C [auth E]	SCOP2 Family	MSL2-CXC	8045980	4004799	SCOP2 (2022-06-29)
C [auth E]	SCOP2 Superfamily	CXC domain-like	8091620	3002037	SCOP2 (2022-06-29)
D [auth F]	SCOP2B Superfamily	CXC domain-like	8091620	3002037	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	PF16682	e4rkhC1	A: few secondary structure elements	X: Zn3Cys9 preSET domain-related (From Topology)	H: Zn3Cys9 preSET domain-related (From Topology)	T: Zn3Cys9 preSET domain-related	F: PF16682	ECOD (1.6)
B [auth D]	PF16682	e4rkhD1	A: few secondary structure elements	X: Zn3Cys9 preSET domain-related (From Topology)	H: Zn3Cys9 preSET domain-related (From Topology)	T: Zn3Cys9 preSET domain-related	F: PF16682	ECOD (1.6)
C [auth E]	PF16682	e4rkhE1	A: few secondary structure elements	X: Zn3Cys9 preSET domain-related (From Topology)	H: Zn3Cys9 preSET domain-related (From Topology)	T: Zn3Cys9 preSET domain-related	F: PF16682	ECOD (1.6)
D [auth F]	PF16682	e4rkhF1	A: few secondary structure elements	X: Zn3Cys9 preSET domain-related (From Topology)	H: Zn3Cys9 preSET domain-related (From Topology)	T: Zn3Cys9 preSET domain-related	F: PF16682	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C], B [auth D], C [auth E], D [auth F]	PF16682	CXC domain of E3 ubiquitin-protein ligase MSL2 (MSL2-CXC)	CXC domain of E3 ubiquitin-protein ligase MSL2	MSL2-CXC is an autonomously folded domain containing that binds three zinc ions. It lies on the E3 ubiquitin-protein ligase MSL2 in eukaryotes. The CXC domain critically contributes to the DNA-binding activity of MSL2 [1]. It carries 9 invariant cyst ...	MSL2-CXC is an autonomously folded domain containing that binds three zinc ions. It lies on the E3 ubiquitin-protein ligase MSL2 in eukaryotes. The CXC domain critically contributes to the DNA-binding activity of MSL2 [1]. It carries 9 invariant cysteines within about a 50 residue region.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth D], C [auth E], D [auth F]	E3 ubiquitin-protein ligase msl-2	DNA binding binding organic cyclic compound binding nucleic acid binding transcription factor binding protein binding protein-containing complex binding chromatin binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity DNA binding binding organic cyclic compound binding nucleic acid binding transcription factor binding protein binding protein-containing complex binding chromatin binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity cation binding ion binding metal ion binding small molecule binding	regulation of cellular process cellular biosynthetic process protein-DNA complex organization cellular component organization organic substance metabolic process chromatin organization organic substance biosynthetic process chromatin remodeling cellular component organization or biogenesis regulation of biosynthetic process regulation of biological process protein-containing complex organization sex-chromosome dosage compensation epigenetic regulation of gene expression regulation of cellular process cellular biosynthetic process protein-DNA complex organization cellular component organization organic substance metabolic process chromatin organization organic substance biosynthetic process chromatin remodeling cellular component organization or biogenesis regulation of biosynthetic process regulation of biological process protein-containing complex organization sex-chromosome dosage compensation epigenetic regulation of gene expression cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process dosage compensation by hyperactivation of X chromosome cellular process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process organonitrogen compound metabolic process protein polyubiquitination primary metabolic process protein ubiquitination macromolecule modification protein metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal protein autoubiquitination	protein-containing complex intracellular anatomical structure catalytic complex protein-DNA complex chromatin chromosome transferase complex cellular anatomical entity histone acetyltransferase complex MSL complex acetyltransferase complex H4 histone acetyltransferase complex intracellular organelle organelle protein-containing complex intracellular anatomical structure catalytic complex protein-DNA complex chromatin chromosome transferase complex cellular anatomical entity histone acetyltransferase complex MSL complex acetyltransferase complex H4 histone acetyltransferase complex intracellular organelle organelle intracellular non-membrane-bounded organelle protein acetyltransferase complex intracellular protein-containing complex non-membrane-bounded organelle sex chromosome X chromosome membrane-bounded organelle nucleus membrane-enclosed lumen nuclear chromosome intracellular membrane-bounded organelle intracellular organelle lumen organelle lumen nuclear lumen dosage compensation complex nuclear protein-containing complex X chromosome located dosage compensation complex, transcription activating ribonucleoprotein complex
E [auth A]	DNA (5'-D(APTPGPAPGPCPGPAPGPAPTPGPGPAP*T)-3')	-	-	-
F [auth B]	DNA (5'-D(APTPCPCPAPTPCPTPCPGPCPTPCPAP*T)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], B [auth D], C [auth E], D [auth F]	IPR017907	Zinc finger, RING-type, conserved site	Conserved Site
A [auth C], B [auth D], C [auth E], D [auth F]	IPR033467	Tesmin/TSO1-like CXC domain	Domain
A [auth C], B [auth D], C [auth E], D [auth F]	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A [auth C], B [auth D], C [auth E], D [auth F]	IPR037922	E3 ubiquitin-protein ligase MSL2	Family
A [auth C], B [auth D], C [auth E], D [auth F]	IPR032049	E3 ubiquitin-protein ligase Msl2, CXC domain	Domain
A [auth C], B [auth D], C [auth E], D [auth F]	IPR001841	Zinc finger, RING-type	Domain
A [auth C], B [auth D], C [auth E], D [auth F]	IPR032043	E3 ubiquitin-protein ligase Msl2, zinc RING finger	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.