4RE6

Acylaminoacyl peptidase complexed with a chloromethylketone inhibitor

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4re6a1	All beta proteins	7-bladed beta-propeller	Peptidase/esterase 'gauge' domain	Acylamino-acid-releasing enzyme, N-terminal donain	Acylamino-acid-releasing enzyme, N-terminal donain	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
A	d4re6a2	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Acylamino-acid-releasing enzyme, C-terminal donain	Acylamino-acid-releasing enzyme, C-terminal donain	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
B	d4re6b1	All beta proteins	7-bladed beta-propeller	Peptidase/esterase 'gauge' domain	Acylamino-acid-releasing enzyme, N-terminal donain	Acylamino-acid-releasing enzyme, N-terminal donain	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
B	d4re6b2	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Acylamino-acid-releasing enzyme, C-terminal donain	Acylamino-acid-releasing enzyme, C-terminal donain	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
C	d4re6c1	All beta proteins	7-bladed beta-propeller	Peptidase/esterase 'gauge' domain	Acylamino-acid-releasing enzyme, N-terminal donain	Acylamino-acid-releasing enzyme, N-terminal donain	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
C	d4re6c2	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Acylamino-acid-releasing enzyme, C-terminal donain	Acylamino-acid-releasing enzyme, C-terminal donain	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
D	d4re6d1	All beta proteins	7-bladed beta-propeller	Peptidase/esterase 'gauge' domain	Acylamino-acid-releasing enzyme, N-terminal donain	Acylamino-acid-releasing enzyme, N-terminal donain	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
D	d4re6d2	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Acylamino-acid-releasing enzyme, C-terminal donain	Acylamino-acid-releasing enzyme, C-terminal donain	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Peptidase/esterase 'gauge' domain	8042437	3001719	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	alpha/beta-Hydrolases	8042438	3000102	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	alpha/beta-Hydrolases	8042438	3000102	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Peptidase/esterase 'gauge' domain	8042437	3001719	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	alpha/beta-Hydrolases	8042438	3000102	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Peptidase/esterase 'gauge' domain	8042437	3001719	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	alpha/beta-Hydrolases	8042438	3000102	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Peptidase/esterase 'gauge' domain	8042437	3001719	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF22173	e4re6A2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF22173	ECOD (1.6)
A	PF00326	e4re6A1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: PF00326	ECOD (1.6)
B	PF22173	e4re6B1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF22173	ECOD (1.6)
B	PF00326	e4re6B2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: PF00326	ECOD (1.6)
C	PF22173	e4re6C2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF22173	ECOD (1.6)
C	PF00326	e4re6C1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: PF00326	ECOD (1.6)
D	PF22173	e4re6D1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF22173	ECOD (1.6)
D	PF00326	e4re6D2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: PF00326	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.130.10.150	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
A	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
B	2.130.10.150	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
B	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
C	2.130.10.150	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
C	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
D	2.130.10.150	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
D	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00326	Prolyl oligopeptidase family (Peptidase_S9)	Prolyl oligopeptidase family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Acylamino-acid-releasing enzyme	peptidase activity serine hydrolase activity catalytic activity, acting on a protein serine-type peptidase activity hydrolase activity catalytic activity omega peptidase activity	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR001375	Peptidase S9, prolyl oligopeptidase, catalytic domain	Domain
A, B, C, D	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.