Annotations: 4R8Q

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00069	e4r8qA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: PF00069	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	6.10.130.20	Special	Helix non-globular	GTP Cyclohydrolase I	Chain A, domain 1	CATH (4.3.0)
A	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Mitotic checkpoint serine/threonine-protein kinase BUB1	catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity histone modifying activity histone H2A kinase activity histone kinase activity	regulation of maintenance of mitotic sister chromatid cohesion positive regulation of organelle organization regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization mitotic sister chromatid cohesion positive regulation of biological process maintenance of sister chromatid cohesion regulation of maintenance of mitotic sister chromatid cohesion, centromeric cellular component organization centromeric sister chromatid cohesion maintenance of mitotic sister chromatid cohesion regulation of centromeric sister chromatid cohesion positive regulation of cell cycle process regulation of maintenance of mitotic sister chromatid cohesion positive regulation of organelle organization regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization mitotic sister chromatid cohesion positive regulation of biological process maintenance of sister chromatid cohesion regulation of maintenance of mitotic sister chromatid cohesion, centromeric cellular component organization centromeric sister chromatid cohesion maintenance of mitotic sister chromatid cohesion regulation of centromeric sister chromatid cohesion positive regulation of cell cycle process cellular component organization or biogenesis cell cycle regulation of cell cycle positive regulation of cellular process cell cycle process regulation of biological process regulation of cell cycle process biological regulation chromosome organization sister chromatid cohesion regulation of chromosome organization positive regulation of maintenance of sister chromatid cohesion positive regulation of maintenance of mitotic sister chromatid cohesion positive regulation of sister chromatid cohesion regulation of organelle organization positive regulation of cell cycle positive regulation of chromosome organization regulation of maintenance of sister chromatid cohesion positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric organelle organization maintenance of mitotic sister chromatid cohesion, centromeric regulation of sister chromatid cohesion mitotic sister chromatid cohesion, centromeric cellular process meiotic sister chromatid cohesion, centromeric meiotic sister chromatid cohesion cell division chromosome segregation cellular response to stimulus regulation of cell cycle phase transition response to stimulus negative regulation of biological process spindle checkpoint signaling negative regulation of cell cycle regulation of mitotic nuclear division intracellular signal transduction negative regulation of mitotic cell cycle cell communication negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition mitotic spindle checkpoint signaling signal transduction mitotic sister chromatid separation negative regulation of sister chromatid segregation mitotic spindle assembly checkpoint signaling negative regulation of cellular component organization sister chromatid segregation regulation of mitotic cell cycle phase transition regulation of mitotic sister chromatid segregation mitotic cell cycle process regulation of chromosome separation negative regulation of mitotic nuclear division regulation of chromosome segregation regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle signaling spindle assembly checkpoint signaling cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle regulation of mitotic cell cycle negative regulation of cellular process mitotic sister chromatid segregation negative regulation of mitotic metaphase/anaphase transition negative regulation of chromosome separation mitotic nuclear division negative regulation of mitotic cell cycle phase transition organelle fission negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling nuclear division negative regulation of chromosome segregation chromosome separation negative regulation of organelle organization negative regulation of nuclear division regulation of sister chromatid segregation negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition apoptotic process cell death programmed cell death phosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process phosphorus metabolic process	membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex chromosome chromosomal region kinetochore intracellular non-membrane-bounded organelle chromosome, centromeric region outer kinetochore condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017441	Protein kinase, ATP binding site	Binding Site
A	IPR000719	Protein kinase domain	Domain
A	IPR015661	Mitotic spindle checkpoint protein Bub1/Mad3	Family
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR013212	Mad3/Bub1 homology region 1	Domain
A	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O43683	mosaic variegated aneuploidy syndrome 1 colorectal cancer malignant glioma malignant pancreatic neoplasm osteosarcoma adrenal cortex carcinoma pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor Sjogren syndrome endometriosis hepatocellular carcinoma large cell medulloblastoma malignant colon neoplasm malignant mesothelioma medulloblastoma mosaic variegated aneuploidy syndrome 1 colorectal cancer malignant glioma malignant pancreatic neoplasm osteosarcoma adrenal cortex carcinoma pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor Sjogren syndrome endometriosis hepatocellular carcinoma large cell medulloblastoma malignant colon neoplasm malignant mesothelioma medulloblastoma nasopharyngeal carcinoma ovarian cancer alopecia areata primitive neuroectodermal tumor breast cancer ulcerative colitis Crohn disease exocrine pancreatic carcinoma IgA glomerulonephritis lung adenocarcinoma malignant ependymoma Malignant neoplasm of pancreas mosaic variegated aneuploidy syndrome non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma atopic eczema psoriasis breast carcinoma ductal breast carcinoma in situ glioblastoma invasive ductal breast carcinoma lung cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.