Annotations: 4R3Z

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	Nucleotidylyl transferase	8092911	3001541	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ribosomal protein L25-like	8092913	3001161	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e4r3zA1	A: extended segments	X: Helical hairpin in Ndc80 (From Topology)	H: Helical hairpin in Ndc80 (From Topology)	T: Helical hairpin in Ndc80	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00750,PF05746	e4r3zB3	A: alpha bundles	X: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases (From Topology)	H: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases (From Topology)	T: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	F: PF00750,PF05746	ECOD (1.6)
B	PF03485	e4r3zB1	A: a+b two layers	X: RRF/tRNA synthetase additional domain-like	H: Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain (From Topology)	T: Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	F: PF03485	ECOD (1.6)
B	PF00750	e4r3zB2	A: a/b three-layered sandwiches	X: HUP domain-like	H: HUP domains (From Topology)	T: HUP domains	F: PF00750	ECOD (1.6)
C	PF03950	e4r3zC3	A: beta barrels	X: Ribosomal protein L25-like	H: Ribosomal protein L25-like (From Topology)	T: Ribosomal protein L25-like	F: PF03950	ECOD (1.6)
C	PF20974	e4r3zC1	A: beta barrels	X: Ribosomal protein L25-like	H: Ribosomal protein L25-like (From Topology)	T: Ribosomal protein L25-like	F: PF20974	ECOD (1.6)
C	PF00749	e4r3zC6	A: alpha bundles	X: Zn-binding domain in glutaminyl-tRNA synthetase (From Topology)	H: Zn-binding domain in glutaminyl-tRNA synthetase (From Topology)	T: Zn-binding domain in glutaminyl-tRNA synthetase	F: PF00749	ECOD (1.6)
C	PF00749,PF04557	e4r3zC4	A: a/b three-layered sandwiches	X: HUP domain-like	H: HUP domains (From Topology)	T: HUP domains	F: PF00749,PF04557	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF03485	Arginyl tRNA synthetase N terminal domain (Arg_tRNA_synt_N)	Arginyl tRNA synthetase N terminal domain	This domain is found at the amino terminus of Arginyl tRNA synthetase, also called additional domain 1 (Add-1). It is about 140 residues long and it has been suggested that this domain will be involved in tRNA recognition [1].	Domain
B	PF00750	tRNA synthetases class I (R) (tRNA-synt_1d)	tRNA synthetases class I (R)	-	Family
B	PF05746	DALR anticodon binding domain (DALR_1)	DALR anticodon binding domain	This all alpha helical domain is the anticodon binding domain in Arginyl and glycyl tRNA synthetase. This domain is known as the DALR domain after characteristic conserved amino acids [1].	Domain
C	PF00749	tRNA synthetases class I (E and Q), catalytic domain (tRNA-synt_1c)	tRNA synthetases class I (E and Q), catalytic domain	Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only glutamyl and glutaminyl tRNA synthetases. In some organisms, a single glutamyl-tRNA synthetase aminoacylates both tRNA(Glu) and tRNA(Gln).	Domain
C	PF03950	tRNA synthetases class I (E and Q), anti-codon binding domain (tRNA-synt_1c_C)	tRNA synthetases class I (E and Q), anti-codon binding domain	This entry represents the first of the two ribosomal L25-like domains of the anticodon binding domain. Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only glutamyl and glutaminyl tRNA synthetases. In some o ...	This entry represents the first of the two ribosomal L25-like domains of the anticodon binding domain. Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only glutamyl and glutaminyl tRNA synthetases. In some organisms, a single glutamyl-tRNA synthetase aminoacylates both tRNA(Glu) and tRNA(Gln).	Domain
C	PF04557	Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 (tRNA_synt_1c_R2)	Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2	-	Family
C	PF20974	tRNA synthetases class I (E and Q), anti-codon binding domain (tRNA-synt_1c_C2)	tRNA synthetases class I (E and Q), anti-codon binding domain	This entry represents the second ribosomal L25 like domain which is part of the anticodon binding domain. Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only glutamyl and glutaminyl tRNA synthetases. In som ...	This entry represents the second ribosomal L25 like domain which is part of the anticodon binding domain. Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only glutamyl and glutaminyl tRNA synthetases. In some organisms, a single glutamyl-tRNA synthetase aminoacylates both tRNA(Glu) and tRNA(Gln).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Aminoacyl tRNA synthase complex-interacting multifunctional protein 1	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity molecular function activator activity signaling receptor binding molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity RNA binding organic cyclic compound binding identical protein binding protein binding binding protein homodimerization activity protein dimerization activity molecular function activator activity signaling receptor binding molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity RNA binding organic cyclic compound binding tRNA binding nucleic acid binding enzyme binding GTPase binding	developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis blood vessel development system development developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis blood vessel development system development leukocyte migration immune system process cell migration cellular process cell motility apoptotic process cell death programmed cell death response to stimulus defense response response to stress inflammatory response regulation of biological process signaling biological regulation cell-cell signaling cell communication positive regulation of cell communication regulation of localization nitrogen compound transport regulation of cellular process localization regulation of glucagon secretion regulation of biological quality regulation of peptide hormone secretion positive regulation of glucagon secretion regulation of hormone levels positive regulation of peptide hormone secretion organic substance transport establishment of localization regulation of secretion regulation of hormone secretion regulation of peptide secretion transport glucagon secretion positive regulation of biological process positive regulation of secretion by cell hormone secretion peptide secretion secretion by cell regulation of secretion by cell positive regulation of hormone secretion positive regulation of secretion amide transport signal release positive regulation of cellular process positive regulation of peptide secretion regulation of signaling secretion regulation of transport regulation of peptide transport export from cell peptide transport positive regulation of transport peptide hormone secretion hormone transport regulation of cell communication positive regulation of signaling biological process involved in interspecies interaction between organisms response to other organism defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to external biotic stimulus response to virus negative regulation of cell population proliferation cell population proliferation endothelial cell proliferation negative regulation of biological process negative regulation of endothelial cell proliferation regulation of endothelial cell proliferation regulation of cell population proliferation negative regulation of cellular process regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process protein metabolic process macromolecule metabolic process	membrane cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system protein-containing complex catalytic complex aminoacyl-tRNA synthetase multienzyme complex intracellular protein-containing complex membrane cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system protein-containing complex catalytic complex aminoacyl-tRNA synthetase multienzyme complex intracellular protein-containing complex cell surface cytosol extracellular region extracellular space nucleus endoplasmic reticulum
B	Arginine--tRNA ligase, cytoplasmic	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cell adhesion molecule binding cadherin binding protein binding ligase activity, forming carbon-oxygen bonds aminoacyl-tRNA ligase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid catalytic activity, acting on a tRNA arginine-tRNA ligase activity catalytic activity ligase activity RNA binding tRNA binding nucleic acid binding cation binding organic acid binding amino acid binding carboxylic acid binding arginine binding	amino acid activation tRNA aminoacylation cellular biosynthetic process organonitrogen compound biosynthetic process RNA metabolic process amino acid metabolic process arginyl-tRNA aminoacylation nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process protein metabolic process organonitrogen compound metabolic process cellular metabolic process primary metabolic process amino acid activation tRNA aminoacylation cellular biosynthetic process organonitrogen compound biosynthetic process RNA metabolic process amino acid metabolic process arginyl-tRNA aminoacylation nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process protein metabolic process organonitrogen compound metabolic process cellular metabolic process primary metabolic process translation gene expression tRNA aminoacylation for protein translation macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process metabolic process cellular process macromolecule metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex catalytic complex aminoacyl-tRNA synthetase multienzyme complex intracellular protein-containing complex cytoplasm cytosol nucleoplasm
C	Glutamine--tRNA ligase	enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity kinase inhibitor activity kinase regulator activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity kinase inhibitor activity kinase regulator activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ligase activity, forming carbon-oxygen bonds aminoacyl-tRNA ligase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid glutamine-tRNA ligase activity catalytic activity, acting on a tRNA catalytic activity ligase activity protein binding kinase binding enzyme binding protein kinase binding	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process cellular response to stimulus response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of stress-activated MAPK cascade regulation of cellular response to stress regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication stress-activated MAPK cascade cellular response to stress regulation of intracellular signal transduction response to stress regulation of response to stress intracellular signaling cassette signal transduction regulation of signaling negative regulation of response to stimulus regulation of stress-activated protein kinase signaling cascade regulation of MAPK cascade negative regulation of signal transduction regulation of stress-activated MAPK cascade stress-activated protein kinase signaling cascade regulation of response to stimulus negative regulation of stress-activated protein kinase signaling cascade MAPK cascade regulation of cell communication negative regulation of MAPK cascade developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development amino acid activation tRNA aminoacylation organonitrogen compound biosynthetic process amino acid metabolic process protein metabolic process organonitrogen compound metabolic process translation tRNA aminoacylation for protein translation tRNA metabolic process ncRNA metabolic process regulation of programmed cell death negative regulation of apoptotic signaling pathway negative regulation of programmed cell death regulation of apoptotic process cell death apoptotic signaling pathway negative regulation of apoptotic process apoptotic process programmed cell death regulation of apoptotic signaling pathway regulation of catalytic activity negative regulation of catalytic activity regulation of transferase activity negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process phosphorus metabolic process protein modification process negative regulation of protein metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process regulation of molecular function regulation of kinase activity negative regulation of protein phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of molecular function negative regulation of protein kinase activity regulation of protein kinase activity negative regulation of phosphorus metabolic process regulation of phosphorylation negative regulation of phosphorylation glutaminyl-tRNA aminoacylation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex catalytic complex aminoacyl-tRNA synthetase multienzyme complex intracellular protein-containing complex membrane-bounded organelle mitochondrion membrane-enclosed lumen intracellular membrane-bounded organelle mitochondrial matrix intracellular organelle lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex catalytic complex aminoacyl-tRNA synthetase multienzyme complex intracellular protein-containing complex membrane-bounded organelle mitochondrion membrane-enclosed lumen intracellular membrane-bounded organelle mitochondrial matrix intracellular organelle lumen intracellular organelle organelle lumen organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002547	tRNA-binding domain	Domain
A	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
B	IPR036695	Arginyl tRNA synthetase N-terminal domain superfamily	Homologous Superfamily
B	IPR005148	Arginyl tRNA synthetase N-terminal domain	Domain
B	IPR001412	Aminoacyl-tRNA synthetase, class I, conserved site	Conserved Site
B	IPR001278	Arginine-tRNA ligase	Family
B	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold	Homologous Superfamily
B	IPR009080	Aminoacyl-tRNA synthetase, class Ia, anticodon-binding	Homologous Superfamily
B	IPR035684	Arginyl-tRNA synthetase, catalytic core domain	Domain
B	IPR008909	DALR anticodon binding	Domain
C	IPR042559	Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2	Homologous Superfamily
C	IPR007638	Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2	Domain
C	IPR001412	Aminoacyl-tRNA synthetase, class I, conserved site	Conserved Site
C	IPR042558	Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1	Homologous Superfamily
C	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold	Homologous Superfamily
C	IPR004514	Glutamine-tRNA synthetase	Family
C	IPR007639	Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal	Domain
C	IPR000924	Glutamyl/glutaminyl-tRNA synthetase	Family
C	IPR020058	Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain	Domain
C	IPR020056	Large ribosomal subunit protein bL25/Gln-tRNA synthetase, N-terminal	Homologous Superfamily
C	IPR049437	tRNA synthetases class I (E and Q), anti-codon binding domain	Domain
C	IPR020059	Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain	Domain
C	IPR011035	Large ribosomal subunit protein bL25/Gln-tRNA synthetase, anti-codon-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q12904	hypomyelinating leukodystrophy 3 leukodystrophy arthrogryposis glioblastoma intellectual disability medulloblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Spastic Paraplegia, Hereditary breast cancer hereditary spastic paraplegia large cell medulloblastoma ovarian cancer plasma cell myeloma tuberculosis pancreatic intraductal papillary-mucinous neoplasm hypomyelinating leukodystrophy 3 leukodystrophy arthrogryposis glioblastoma intellectual disability medulloblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Spastic Paraplegia, Hereditary breast cancer hereditary spastic paraplegia large cell medulloblastoma ovarian cancer plasma cell myeloma tuberculosis pancreatic intraductal papillary-mucinous neoplasm progressive supranuclear palsy
B	Pharos: P54136	hypomyelinating leukodystrophy 9 leukodystrophy acute myeloid leukemia IgA glomerulonephritis
C	Pharos: P47897	diffuse cerebral and cerebellar atrophy - intractable seizures - progressive microcephaly syndrome prostate cancer microcephaly Primary microcephaly astrocytic tumor endogenous depression intellectual disability medulloblastoma myocardial infarction ovarian cancer atypical teratoid rhabdoid tumor endometriosis glioblastoma large cell medulloblastoma oligodendroglioma diffuse cerebral and cerebellar atrophy - intractable seizures - progressive microcephaly syndrome prostate cancer microcephaly Primary microcephaly astrocytic tumor endogenous depression intellectual disability medulloblastoma myocardial infarction ovarian cancer atypical teratoid rhabdoid tumor endometriosis glioblastoma large cell medulloblastoma oligodendroglioma plasma cell myeloma epilepsy heart disease lymphoplasmacytic lymphoma osteosarcoma