4QQF

Crystal structure of mitochondrial import inner membrane translocase subunit TIM50

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth D]	PF03031	e4qqfD1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: PF03031	ECOD (1.6)
B [auth A]	PF03031	e4qqfA1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: PF03031	ECOD (1.6)
C [auth B]	PF03031	e4qqfB1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: PF03031	ECOD (1.6)
D [auth C]	PF03031	e4qqfC1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: PF03031	ECOD (1.6)
E	PF03031	e4qqfE1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: PF03031	ECOD (1.6)
F	PF03031	e4qqfF1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: PF03031	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth D]	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
B [auth A]	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
C [auth B]	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
D [auth C]	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
E	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
F	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth D], B [auth A], C [auth B], D [auth C], E, A [auth D], B [auth A], C [auth B], D [auth C], E, F	PF03031	NLI interacting factor-like phosphatase (NIF)	NLI interacting factor-like phosphatase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D], B [auth A], C [auth B], D [auth C], E, A [auth D], B [auth A], C [auth B], D [auth C], E, F	Mitochondrial import inner membrane translocase subunit TIM50	signal sequence binding binding peptide binding mitochondrion targeting sequence binding identical protein binding protein binding	protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process intracellular protein transport establishment of protein localization to mitochondrial membrane protein targeting mitochondrial membrane organization cellular component organization cellular component organization or biogenesis protein insertion into mitochondrial inner membrane mitochondrial transport mitochondrion organization membrane organization establishment of protein localization to membrane inner mitochondrial membrane organization localization within membrane protein localization to membrane organelle organization establishment of protein localization to organelle protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion establishment of protein localization to mitochondrion protein transmembrane import into intracellular organelle protein import into mitochondrial matrix protein transmembrane transport mitochondrial transmembrane transport transmembrane transport import into the mitochondrion biological regulation regulation of membrane permeability regulation of biological quality regulation of mitochondrial membrane permeability	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane mitochondrial protein-containing complex protein-containing complex TIM23 mitochondrial import inner membrane translocase complex membrane protein complex inner mitochondrial membrane protein complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth D], B [auth A], C [auth B], D [auth C], E, A [auth D], B [auth A], C [auth B], D [auth C], E, F	IPR004274	FCP1 homology domain	Domain
A [auth D], B [auth A], C [auth B], D [auth C], E, A [auth D], B [auth A], C [auth B], D [auth C], E, F	IPR036412	HAD-like superfamily	Homologous Superfamily
A [auth D], B [auth A], C [auth B], D [auth C], E, A [auth D], B [auth A], C [auth B], D [auth C], E, F	IPR023214	HAD superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth D], B [auth A], C [auth B], D [auth C], E A [auth D], B [auth A], C [auth B], D [auth C], E, F	OPM	Transmembrane	Bitopic proteins	NLI interacting factor-like phosphatase	Mitochondrial translocase subunit TIM50

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.