4QEB

Dcps in complex with covalent inhibitor targeting Tyrosine

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	mRNA decapping enzyme DcpS N-terminal domain	8041668	3001367	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	HIT-like	8041667	3000223	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	HIT-like	8041667	3000223	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	mRNA decapping enzyme DcpS N-terminal domain	8041668	3001367	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	mRNA decapping enzyme DcpS N-terminal domain	8041668	3001367	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	HIT-like	8041667	3000223	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	HIT-like	8041667	3000223	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	mRNA decapping enzyme DcpS N-terminal domain	8041668	3001367	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF05652	e4qebA1	A: a+b two layers	X: mRNA decapping enzyme DcpS N-terminal domain (From Topology)	H: mRNA decapping enzyme DcpS N-terminal domain (From Topology)	T: mRNA decapping enzyme DcpS N-terminal domain	F: PF05652	ECOD (1.6)
A	PF11969	e4qebA2	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: PF11969	ECOD (1.6)
B	PF05652	e4qebB1	A: a+b two layers	X: mRNA decapping enzyme DcpS N-terminal domain (From Topology)	H: mRNA decapping enzyme DcpS N-terminal domain (From Topology)	T: mRNA decapping enzyme DcpS N-terminal domain	F: PF05652	ECOD (1.6)
B	PF11969	e4qebB2	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: PF11969	ECOD (1.6)
C	PF05652	e4qebC1	A: a+b two layers	X: mRNA decapping enzyme DcpS N-terminal domain (From Topology)	H: mRNA decapping enzyme DcpS N-terminal domain (From Topology)	T: mRNA decapping enzyme DcpS N-terminal domain	F: PF05652	ECOD (1.6)
C	PF11969	e4qebC2	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: PF11969	ECOD (1.6)
D	PF05652	e4qebD2	A: a+b two layers	X: mRNA decapping enzyme DcpS N-terminal domain (From Topology)	H: mRNA decapping enzyme DcpS N-terminal domain (From Topology)	T: mRNA decapping enzyme DcpS N-terminal domain	F: PF05652	ECOD (1.6)
D	PF11969	e4qebD1	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: PF11969	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.200.40	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
A	3.30.428.10	Alpha Beta	2-Layer Sandwich	HIT family, subunit A	HIT-like	CATH (4.3.0)
B	3.30.200.40	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
B	3.30.2240.10	Alpha Beta	2-Layer Sandwich	mRNA decapping enzyme DcpS N-terminal fold	mRNA decapping enzyme DcpS N-terminal domain	CATH (4.3.0)
B	3.30.428.10	Alpha Beta	2-Layer Sandwich	HIT family, subunit A	HIT-like	CATH (4.3.0)
C	3.30.200.40	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
C	3.30.2240.10	Alpha Beta	2-Layer Sandwich	mRNA decapping enzyme DcpS N-terminal fold	mRNA decapping enzyme DcpS N-terminal domain	CATH (4.3.0)
C	3.30.428.10	Alpha Beta	2-Layer Sandwich	HIT family, subunit A	HIT-like	CATH (4.3.0)
D	3.30.200.40	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
D	3.30.428.10	Alpha Beta	2-Layer Sandwich	HIT family, subunit A	HIT-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF11969	Scavenger mRNA decapping enzyme C-term binding (DcpS_C)	Scavenger mRNA decapping enzyme C-term binding	-	Family
A, B, C, D	PF05652	Scavenger mRNA decapping enzyme (DcpS) N-terminal (DcpS)	Scavenger mRNA decapping enzyme (DcpS) N-terminal	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	m7GpppX diphosphatase	RNA binding binding organic cyclic compound binding RNA 7-methylguanosine cap binding nucleic acid binding RNA cap binding nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA exonuclease activity RNA nuclease activity hydrolase activity exonuclease activity RNA binding binding organic cyclic compound binding RNA 7-methylguanosine cap binding nucleic acid binding RNA cap binding nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA exonuclease activity RNA nuclease activity hydrolase activity exonuclease activity catalytic activity pyrophosphatase activity 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides identical protein binding protein binding	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA catabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA catabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process negative regulation of metabolic process positive regulation of mRNA metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process nucleobase-containing compound catabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process deadenylation-dependent decapping of nuclear-transcribed mRNA regulation of metabolic process RNA decapping nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay catabolic process cellular biosynthetic process positive regulation of biological process RNA metabolic process macromolecule catabolic process mRNA destabilization organic substance metabolic process regulation of mRNA catabolic process negative regulation of cellular process mRNA methylguanosine-cap decapping negative regulation of macromolecule metabolic process regulation of biosynthetic process nuclear-transcribed mRNA catabolic process RNA destabilization biological regulation regulation of macromolecule metabolic process regulation of catabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound catabolic process regulation of cellular biosynthetic process positive regulation of catabolic process regulation of mRNA stability negative regulation of biosynthetic process positive regulation of mRNA catabolic process regulation of RNA stability cellular process regulation of mRNA metabolic process organic substance catabolic process mRNA processing RNA processing RNA splicing RNA splicing, via transesterification reactions mRNA cis splicing, via spliceosome mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular non-membrane-bounded organelle supramolecular complex P-body membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular non-membrane-bounded organelle supramolecular complex P-body non-membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR011145	Scavenger mRNA decapping enzyme, N-terminal	Homologous Superfamily
A, B, C, D	IPR008594	Scavenger mRNA decapping enzyme DcpS/DCS2	Family
A, B, C, D	IPR036265	HIT-like superfamily	Homologous Superfamily
A, B, C, D	IPR019808	Histidine triad, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q96C86	Al-Raqad syndrome lung cancer ulcerative colitis hypertensive disorder osteosarcoma intellectual disability pancreatic ductal adenocarcinoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.