4Q28

Crystal Structure of the Plectin 1 and 2 Repeats of the Human Periplakin. Northeast Structural Genomics Consortium (NESG) Target HR9083A

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF00681	e4q28B1	A: a+b duplicates or obligate multimers	X: beta-hairpin-alpha-hairpin repeat (From Topology)	H: beta-hairpin-alpha-hairpin repeat (From Topology)	T: beta-hairpin-alpha-hairpin repeat	F: PF00681	ECOD (1.6)
A	PF00681	e4q28A1	A: a+b duplicates or obligate multimers	X: beta-hairpin-alpha-hairpin repeat (From Topology)	H: beta-hairpin-alpha-hairpin repeat (From Topology)	T: beta-hairpin-alpha-hairpin repeat	F: PF00681	ECOD (1.6)
C	PF00681	e4q28C1	A: a+b duplicates or obligate multimers	X: beta-hairpin-alpha-hairpin repeat (From Topology)	H: beta-hairpin-alpha-hairpin repeat (From Topology)	T: beta-hairpin-alpha-hairpin repeat	F: PF00681	ECOD (1.6)
D	PF00681	e4q28D1	A: a+b duplicates or obligate multimers	X: beta-hairpin-alpha-hairpin repeat (From Topology)	H: beta-hairpin-alpha-hairpin repeat (From Topology)	T: beta-hairpin-alpha-hairpin repeat	F: PF00681	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.160.780	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain		CATH (4.3.0)
A	3.30.160.780	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain		CATH (4.3.0)
C	3.30.160.780	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain		CATH (4.3.0)
D	3.30.160.780	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain		CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Periplakin	cell adhesion molecule binding cadherin binding protein binding binding structural constituent of cytoskeleton structural molecule activity	response to stimulus response to mechanical stimulus response to abiotic stimulus response to external stimulus developmental process multicellular organismal process epithelium development keratinization epidermal cell differentiation cellular developmental process epidermis development animal organ development tissue development epithelial cell differentiation response to stimulus response to mechanical stimulus response to abiotic stimulus response to external stimulus developmental process multicellular organismal process epithelium development keratinization epidermal cell differentiation cellular developmental process epidermis development animal organ development tissue development epithelial cell differentiation skin development cell differentiation keratinocyte differentiation anatomical structure development cellular process wound healing response to stress response to wounding cellular component organization intermediate filament-based process organelle organization cellular component organization or biogenesis cytoskeleton organization intermediate filament cytoskeleton organization	cell periphery plasma membrane membrane cellular anatomical entity cornified envelope intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle extracellular exosome membrane-bounded organelle extracellular vesicle cell periphery plasma membrane membrane cellular anatomical entity cornified envelope intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol cell-cell junction anchoring junction desmosome cell junction

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR041615	Desmoplakin, SH3 domain	Domain
A, B, C, D	IPR043197	Plakin	Family
A, B, C, D	IPR001101	Plectin repeat	Repeat
A, B, C, D	IPR035915	Plakin repeat superfamily	Homologous Superfamily
A, B, C, D	IPR001452	SH3 domain	Domain
A, B, C, D	IPR018159	Spectrin/alpha-actinin	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: O60437	prostate cancer Prostatic Neoplasms astrocytic tumor ductal breast carcinoma in situ interstitial cystitis lung cancer nasopharyngeal carcinoma Pick disease spina bifida breast cancer esophageal adenocarcinoma invasive ductal breast carcinoma medulloblastoma oligodendroglioma pilocytic astrocytoma prostate cancer Prostatic Neoplasms astrocytic tumor ductal breast carcinoma in situ interstitial cystitis lung cancer nasopharyngeal carcinoma Pick disease spina bifida breast cancer esophageal adenocarcinoma invasive ductal breast carcinoma medulloblastoma oligodendroglioma pilocytic astrocytoma prostate carcinoma breast carcinoma glioblastoma large cell medulloblastoma myopathy ovarian cancer primitive neuroectodermal tumor

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.