Annotations: 4Q0Z

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e4q0zA2	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00752,PF00867	e4q0zA1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: PIN domain-like	F: PF00752,PF00867	ECOD (1.6)
B	F_UNCLASSIFIED	e4q0zB2	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00752,PF00867	e4q0zB1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: PIN domain-like	F: PF00752,PF00867	ECOD (1.6)
E	F_UNCLASSIFIED	e4q0zE1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: F_UNCLASSIFIED	ECOD (1.6)
E	PF00752,PF00867	e4q0zE2	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: PIN domain-like	F: PF00752,PF00867	ECOD (1.6)
F	F_UNCLASSIFIED	e4q0zF2	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: F_UNCLASSIFIED	ECOD (1.6)
F	PF00752,PF00867	e4q0zF1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: PIN domain-like	F: PF00752,PF00867	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, E, F	PF00867	XPG I-region (XPG_I)	XPG I-region	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, E, F	Rad2p	DNA endonuclease activity endonuclease activity catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on a nucleic acid hydrolase activity single-stranded DNA endodeoxyribonuclease activity catalytic activity DNA nuclease activity cation binding ion binding binding metal ion binding DNA endonuclease activity endonuclease activity catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on a nucleic acid hydrolase activity single-stranded DNA endodeoxyribonuclease activity catalytic activity DNA nuclease activity cation binding ion binding binding metal ion binding small molecule binding DNA binding organic cyclic compound binding single-stranded DNA binding nucleic acid binding	cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process transcription by RNA polymerase II organic substance metabolic process cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process transcription by RNA polymerase II organic substance metabolic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process cellular process macromolecule metabolic process cellular response to stimulus response to stimulus DNA metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress DNA repair	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleotide-excision repair factor 3 complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle nucleotide-excision repair complex
C, G	DNA (5'-D(TPGPCPTPCPCPCPTPTPGPTPCPTPCPAPGP*T)-3')	-	-	-
D, H	DNA (5'-D(TPCPTPGPAPGPAPCPAPAPGPGPGPAPGPCP*T)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, E, F	IPR006086	XPG-I domain	Domain
A, B, E, F	IPR001044	XPG/Rad2 endonuclease, eukaryotes	Family
A, B, E, F	IPR029060	PIN-like domain superfamily	Homologous Superfamily
A, B, E, F	IPR036279	5'-3' exonuclease, C-terminal domain superfamily	Homologous Superfamily
A, B, E, F	IPR008918	Helix-hairpin-helix motif, class 2	Conserved Site
A, B, E, F	IPR019974	XPG conserved site	Conserved Site
A, B, E, F	IPR006085	XPG, N-terminal	Domain
A, B, E, F	IPR006084	XPG/Rad2 endonuclease	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.