4PRO

ALPHA-LYTIC PROTEASE COMPLEXED WITH PRO REGION

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4proa_	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Prokaryotic proteases	alpha-Lytic protease	(Lysobacter enzymogenes ) [TaxId: 69 ],	SCOPe (2.08)
C [auth B]	d4prob_	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Prokaryotic proteases	alpha-Lytic protease	(Lysobacter enzymogenes ) [TaxId: 69 ],	SCOPe (2.08)
B [auth C]	d4proc1	Alpha and beta proteins (a+b)	Alpha-lytic protease prodomain-like	Alpha-lytic protease prodomain	Alpha-lytic protease prodomain	Alpha-lytic protease prodomain	(Lysobacter enzymogenes ) [TaxId: 69 ],	SCOPe (2.08)
D	d4prod1	Alpha and beta proteins (a+b)	Alpha-lytic protease prodomain-like	Alpha-lytic protease prodomain	Alpha-lytic protease prodomain	Alpha-lytic protease prodomain	(Lysobacter enzymogenes ) [TaxId: 69 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Trypsin-like serine proteases	8042155	3000114	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Trypsin-like serine proteases	8042155	3000114	SCOP2B (2022-06-29)
B [auth C]	SCOP2 Family	Alpha-lytic protease prodomain	8022735	4001194	SCOP2 (2022-06-29)
B [auth C]	SCOP2 Family	Alpha-lytic protease prodomain	8022737	4001194	SCOP2 (2022-06-29)
B [auth C]	SCOP2 Superfamily	Alpha-lytic protease prodomain	8035115	3001031	SCOP2 (2022-06-29)
B [auth C]	SCOP2 Superfamily	Alpha-lytic protease prodomain	8035117	3001031	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Alpha-lytic protease prodomain	8035115	3001031	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Alpha-lytic protease prodomain	8035117	3001031	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00089	e4proA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: PF00089	ECOD (1.6)
C [auth B]	PF00089	e4proB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: PF00089	ECOD (1.6)
B [auth C]	F_UNCLASSIFIED	e4proC1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Alpha-lytic protease prodomain (From Topology)	T: Alpha-lytic protease prodomain	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth C]	PF02983	e4proC2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Alpha-lytic protease prodomain (From Topology)	T: Alpha-lytic protease prodomain	F: PF02983	ECOD (1.6)
D	F_UNCLASSIFIED	e4proD1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Alpha-lytic protease prodomain (From Topology)	T: Alpha-lytic protease prodomain	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF02983	e4proD2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Alpha-lytic protease prodomain (From Topology)	T: Alpha-lytic protease prodomain	F: PF02983	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)
C [auth B]	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)
B [auth C]	3.30.300.50	Alpha Beta	2-Layer Sandwich	GMP Synthetase	Chain A, domain 3	CATH (4.3.0)
D	3.30.300.50	Alpha Beta	2-Layer Sandwich	GMP Synthetase	Chain A, domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B]	PF00089	Trypsin (Trypsin)	Trypsin	-	Domain
B [auth C], D	PF02983	Alpha-lytic protease prodomain (Pro_Al_protease)	Alpha-lytic protease prodomain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B]	ALPHA-LYTIC PROTEASE	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	extracellular region cellular anatomical entity
B [auth C], D	ALPHA-LYTIC PROTEASE	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B]	IPR001254	Serine proteases, trypsin domain	Domain
A, C [auth B]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A, C [auth B]	IPR035070	Streptogrisin prodomain	Homologous Superfamily
A, C [auth B]	IPR004236	Peptidase S1A, alpha-lytic prodomain	Domain
A, C [auth B]	IPR037295	Alpha-lytic protease prodomain	Homologous Superfamily
A, C [auth B]	IPR001316	Peptidase S1A, streptogrisin	Family
A, C [auth B]	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
B [auth C], D	IPR001254	Serine proteases, trypsin domain	Domain
B [auth C], D	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
B [auth C], D	IPR035070	Streptogrisin prodomain	Homologous Superfamily
B [auth C], D	IPR004236	Peptidase S1A, alpha-lytic prodomain	Domain
B [auth C], D	IPR037295	Alpha-lytic protease prodomain	Homologous Superfamily
B [auth C], D	IPR001316	Peptidase S1A, streptogrisin	Family
B [auth C], D	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.