Annotations: 4PPH

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4ppha_	All beta proteins	Acid proteases	Acid proteases	automated matches	automated matches	(Lupinus angustifolius ) [TaxId: 3871 ],	SCOPe (2.08)
B	d4pphb_	All beta proteins	Acid proteases	Acid proteases	automated matches	automated matches	(Lupinus angustifolius ) [TaxId: 3871 ],	SCOPe (2.08)
C	d4pphc_	All beta proteins	Acid proteases	Acid proteases	automated matches	automated matches	(Lupinus angustifolius ) [TaxId: 3871 ],	SCOPe (2.08)
D	d4pphd_	All beta proteins	Acid proteases	Acid proteases	automated matches	automated matches	(Lupinus angustifolius ) [TaxId: 3871 ],	SCOPe (2.08)
E	d4pphe_	All beta proteins	Acid proteases	Acid proteases	automated matches	automated matches	(Lupinus angustifolius ) [TaxId: 3871 ],	SCOPe (2.08)
F	d4pphf_	All beta proteins	Acid proteases	Acid proteases	automated matches	automated matches	(Lupinus angustifolius ) [TaxId: 3871 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF14541	e4pphA2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF14541	ECOD (1.6)
A	PF14543	e4pphA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF14543	ECOD (1.6)
B	PF14541	e4pphB2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF14541	ECOD (1.6)
B	PF14543	e4pphB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF14543	ECOD (1.6)
C	PF14541	e4pphC2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF14541	ECOD (1.6)
C	PF14543	e4pphC1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF14543	ECOD (1.6)
D	PF14541	e4pphD2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF14541	ECOD (1.6)
D	PF14543	e4pphD1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF14543	ECOD (1.6)
E	PF14541	e4pphE1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF14541	ECOD (1.6)
E	PF14543	e4pphE2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF14543	ECOD (1.6)
F	PF14541	e4pphF1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF14541	ECOD (1.6)
F	PF14543	e4pphF2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF14543	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)
B	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)
C	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)
D	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)
E	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)
F	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF14541	Xylanase inhibitor C-terminal (TAXi_C)	Xylanase inhibitor C-terminal	This domain is found C-terminal in some aspartic proteinases and in xylanase inhibitors. The activity of these proteins is vital for plant-survival as xylanase produced by phytopathogens destroys plant cells. In TAXI-type inhibitors, this domain is i ...	This domain is found C-terminal in some aspartic proteinases and in xylanase inhibitors. The activity of these proteins is vital for plant-survival as xylanase produced by phytopathogens destroys plant cells. In TAXI-type inhibitors, this domain is important for the differences in xylanase specificity [1-3].	Domain
A, B, C, D, E A, B, C, D, E, F	PF14543	Xylanase inhibitor N-terminal (TAXi_N)	Xylanase inhibitor N-terminal	This domain is found N-terminal in some aspartic proteinases and in xylanase inhibitors. The activity of these proteins is vital for plant-survival as xylanase produced by phytopathogens destroys plant cells [1-3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Conglutin gamma	aspartic-type peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity aspartic-type endopeptidase activity catalytic activity endopeptidase activity	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR032861	Xylanase inhibitor, N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR033121	Peptidase family A1 domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR001461	Aspartic peptidase A1 family	Family
A, B, C, D, E A, B, C, D, E, F	IPR021109	Aspartic peptidase domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR032799	Xylanase inhibitor, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR033868	Xylanase inhibitor I-like	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.