Annotations: 4POG

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Nucleic acid-binding proteins	8063618	3000135	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF17207	e4pogA1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
A	PF14551	e4pogA3	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
A	F_UNCLASSIFIED	e4pogA2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF17207	e4pogB1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
B	PF14551	e4pogB3	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
B	F_UNCLASSIFIED	e4pogB2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF17207	e4pogC1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
C	PF14551	e4pogC3	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
C	F_UNCLASSIFIED	e4pogC2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF17207	e4pogD1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
D	PF14551	e4pogD3	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
D	F_UNCLASSIFIED	e4pogD2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
E	PF17207	e4pogE1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
E	PF14551	e4pogE3	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
E	F_UNCLASSIFIED	e4pogE2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
F	PF17207	e4pogF1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
F	PF14551	e4pogF3	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
F	F_UNCLASSIFIED	e4pogF2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
G	PF17207	e4pogG1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
G	PF14551	e4pogG3	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
G	F_UNCLASSIFIED	e4pogG2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
H	PF17207	e4pogH1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
H	PF14551	e4pogH3	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
H	F_UNCLASSIFIED	e4pogH2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
I	PF17207	e4pogI1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
I	PF14551	e4pogI3	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
I	F_UNCLASSIFIED	e4pogI2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
J	PF17207	e4pogJ1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
J	PF14551	e4pogJ3	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
J	F_UNCLASSIFIED	e4pogJ2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
K	PF17207	e4pogK1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
K	PF14551	e4pogK3	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
K	F_UNCLASSIFIED	e4pogK2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
L	PF17207	e4pogL1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
L	PF14551	e4pogL3	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
L	F_UNCLASSIFIED	e4pogL2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.1640.10	Alpha Beta	2-Layer Sandwich	mini-chromosome maintenance (MCM) complex, chain A, domain 1	mini-chromosome maintenance (MCM) complex, chain A, domain 1	CATH (4.3.0)
A	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
A	2.20.28.10	Mainly Beta	Single Sheet	Rubrerythrin, domain 2		CATH (4.3.0)
B	3.30.1640.10	Alpha Beta	2-Layer Sandwich	mini-chromosome maintenance (MCM) complex, chain A, domain 1	mini-chromosome maintenance (MCM) complex, chain A, domain 1	CATH (4.3.0)
B	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
B	2.20.28.10	Mainly Beta	Single Sheet	Rubrerythrin, domain 2		CATH (4.3.0)
C	3.30.1640.10	Alpha Beta	2-Layer Sandwich	mini-chromosome maintenance (MCM) complex, chain A, domain 1	mini-chromosome maintenance (MCM) complex, chain A, domain 1	CATH (4.3.0)
C	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
C	2.20.28.10	Mainly Beta	Single Sheet	Rubrerythrin, domain 2		CATH (4.3.0)
D	3.30.1640.10	Alpha Beta	2-Layer Sandwich	mini-chromosome maintenance (MCM) complex, chain A, domain 1	mini-chromosome maintenance (MCM) complex, chain A, domain 1	CATH (4.3.0)
D	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
D	2.20.28.10	Mainly Beta	Single Sheet	Rubrerythrin, domain 2		CATH (4.3.0)
E	3.30.1640.10	Alpha Beta	2-Layer Sandwich	mini-chromosome maintenance (MCM) complex, chain A, domain 1	mini-chromosome maintenance (MCM) complex, chain A, domain 1	CATH (4.3.0)
E	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
E	2.20.28.10	Mainly Beta	Single Sheet	Rubrerythrin, domain 2		CATH (4.3.0)
F	3.30.1640.10	Alpha Beta	2-Layer Sandwich	mini-chromosome maintenance (MCM) complex, chain A, domain 1	mini-chromosome maintenance (MCM) complex, chain A, domain 1	CATH (4.3.0)
F	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
F	2.20.28.10	Mainly Beta	Single Sheet	Rubrerythrin, domain 2		CATH (4.3.0)
G	3.30.1640.10	Alpha Beta	2-Layer Sandwich	mini-chromosome maintenance (MCM) complex, chain A, domain 1	mini-chromosome maintenance (MCM) complex, chain A, domain 1	CATH (4.3.0)
G	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
G	2.20.28.10	Mainly Beta	Single Sheet	Rubrerythrin, domain 2		CATH (4.3.0)
H	3.30.1640.10	Alpha Beta	2-Layer Sandwich	mini-chromosome maintenance (MCM) complex, chain A, domain 1	mini-chromosome maintenance (MCM) complex, chain A, domain 1	CATH (4.3.0)
H	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
H	2.20.28.10	Mainly Beta	Single Sheet	Rubrerythrin, domain 2		CATH (4.3.0)
I	3.30.1640.10	Alpha Beta	2-Layer Sandwich	mini-chromosome maintenance (MCM) complex, chain A, domain 1	mini-chromosome maintenance (MCM) complex, chain A, domain 1	CATH (4.3.0)
I	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
I	2.20.28.10	Mainly Beta	Single Sheet	Rubrerythrin, domain 2		CATH (4.3.0)
J	3.30.1640.10	Alpha Beta	2-Layer Sandwich	mini-chromosome maintenance (MCM) complex, chain A, domain 1	mini-chromosome maintenance (MCM) complex, chain A, domain 1	CATH (4.3.0)
J	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
J	2.20.28.10	Mainly Beta	Single Sheet	Rubrerythrin, domain 2		CATH (4.3.0)
K	3.30.1640.10	Alpha Beta	2-Layer Sandwich	mini-chromosome maintenance (MCM) complex, chain A, domain 1	mini-chromosome maintenance (MCM) complex, chain A, domain 1	CATH (4.3.0)
K	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
K	2.20.28.10	Mainly Beta	Single Sheet	Rubrerythrin, domain 2		CATH (4.3.0)
L	3.30.1640.10	Alpha Beta	2-Layer Sandwich	mini-chromosome maintenance (MCM) complex, chain A, domain 1	mini-chromosome maintenance (MCM) complex, chain A, domain 1	CATH (4.3.0)
L	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
L	2.20.28.10	Mainly Beta	Single Sheet	Rubrerythrin, domain 2		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	Cell division control protein 21	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding endonuclease activity nuclease activity hydrolase activity, acting on ester bonds hydrolase activity catalytic activity cation binding metal ion binding	intein-mediated protein splicing organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process biosynthetic process proteolysis organic substance biosynthetic process protein processing metabolic process intein-mediated protein splicing organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process biosynthetic process proteolysis organic substance biosynthetic process protein processing metabolic process cellular process protein metabolic process macromolecule metabolic process protein splicing cell division cellular component organization DNA duplex unwinding organelle organization DNA geometric change chromosome organization DNA conformation change cellular component organization or biogenesis	-
M [auth X], N [auth V], O [auth Y], P [auth Z]	30-mer oligo(dT)	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR036844	Hint domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR027925	MCM, N-terminal domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR031327	Mini-chromosome maintenance protein	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR006142	Intein	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR004042	Intein DOD homing endonuclease	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR006141	Intein N-terminal splicing region	PTM
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR033762	MCM OB domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR003587	Hint domain N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR001208	MCM domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR041562	MCM, AAA-lid domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR030934	Intein C-terminal splicing region	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR003586	Hint domain C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily