4PLK
Hepatitis E Virus E2s domain (Genotype I) in complex with a neutralizing antibody 8G12
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
| Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
|---|---|---|---|---|---|
| A | SCOP2B Superfamily | Norovirus P2 domain-like | 8093124 | 3002678 | SCOP2B (2022-06-29) |
| B | SCOP2B Superfamily | Norovirus P2 domain-like | 8093124 | 3002678 | SCOP2B (2022-06-29) |
| G [auth E] | SCOP2 Family | Hepatitis virus capsid protein P2 domain-like | 8050975 | 4007137 | SCOP2 (2022-06-29) |
| G [auth E] | SCOP2 Superfamily | Norovirus P2 domain-like | 8093124 | 3002678 | SCOP2 (2022-06-29) |
| H [auth F] | SCOP2B Superfamily | Norovirus P2 domain-like | 8093124 | 3002678 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
| Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
|---|---|---|---|---|---|---|---|---|
| A | PF20752 | e4plkA1 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: Phage tail proteins | F: PF20752 | ECOD (1.6) |
| B | PF20752 | e4plkB1 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: Phage tail proteins | F: PF20752 | ECOD (1.6) |
| G [auth E] | PF20752 | e4plkE1 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: Phage tail proteins | F: PF20752 | ECOD (1.6) |
| H [auth F] | PF20752 | e4plkF1 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: Phage tail proteins | F: PF20752 | ECOD (1.6) |
| C [auth L] | PF07654 | e4plkL2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
| C [auth L] | PF07686 | e4plkL1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
| E [auth C] | PF07654 | e4plkC1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
| E [auth C] | PF07686 | e4plkC2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
| I [auth K] | PF07654 | e4plkK2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
| I [auth K] | PF07686 | e4plkK1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
| K [auth G] | PF07654 | e4plkG2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
| K [auth G] | PF07686 | e4plkG1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
| D [auth H] | PF07654 | e4plkH2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
| D [auth H] | PF07686 | e4plkH1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
| F [auth D] | PF07654 | e4plkD1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
| F [auth D] | PF07686 | e4plkD2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
| J | PF07654 | e4plkJ2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
| J | PF07686 | e4plkJ1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
| L [auth I] | PF07654 | e4plkI2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
| L [auth I] | PF07686 | e4plkI1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
| Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
|---|---|---|---|---|---|---|
| C [auth L] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
| E [auth C] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
| I [auth K] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
| K [auth G] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
| D [auth H] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
| F [auth D] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
| J | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
| L [auth I] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
IMGT Antibody Annotation IMGT Database Homepage
| Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
|---|---|---|---|---|---|---|---|---|
| C [auth L], E [auth C], I [auth K], K [auth G] | 8G12 Fab | L-KAPPA | Mus musculus (house mouse) | IGKV12-46*01, IGKJ4*01, IGKC*01, IGKC*02 | V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA | IG | FAB-GAMMA-1_KAPPA | IMGT (202418-0) |
| D [auth H], F [auth D], J, L [auth I] | 8G12 Fab | VH-CH1 | Mus musculus (house mouse) | IGHV1S29*02, IGHJ3*01, IGHG1*02 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-1_KAPPA | IMGT (202418-0) |
SAbDab Antibody Annotation SAbDab Database Homepage
| Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
|---|---|---|---|---|---|
| C [auth L], E [auth C], I [auth K], K [auth G] | Light Chain | IGKV12 | Kappa | capsid protein | SAbDab (2024-05-10) |
| D [auth H], F [auth D], J, L [auth I] | Heavy Chain | IGHV1 | - | capsid protein | SAbDab (2024-05-10) |
Protein Family Annotation Pfam Database Homepage
| Chains | Accession | Name | Description | Comments | Source |
|---|---|---|---|---|---|
| A, B, G [auth E], H [auth F] | PF20752 | Structural protein 2 C-terminal domain (SP2_C) | Structural protein 2 C-terminal domain | This entry represents the third domain of structural protein 2 of the hepatitis E virus. This domain has a RIFT-like fold. The high basic amino acid content of this protein has lead to the suggestion of a role in viral genomic RNA encapsidation. | Domain |
InterPro: Protein Family Classification InterPro Database Homepage
| Chains | Accession | Name | Type |
|---|---|---|---|
| A, B, G [auth E], H [auth F] | IPR048794 | Structural protein 2, C-terminal domain | Domain |
