Annotations: 4PL9

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	HATPase_c	e4pl9A1	A: a+b two layers	X: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like	H: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase (From Topology)	T: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	F: HATPase_c	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.565.10	Alpha Beta	2-Layer Sandwich	Heat Shock Protein 90	Histidine kinase-like ATPase, C-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02518	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Ethylene receptor 1	catalytic activity, acting on a protein small molecule sensor activity kinase activity protein kinase activity transferase activity phosphotransferase activity, nitrogenous group as acceptor phosphotransferase activity, alcohol group as acceptor protein histidine kinase activity transferase activity, transferring phosphorus-containing groups phosphorelay sensor kinase activity catalytic activity binding adenyl ribonucleotide binding nucleotide binding catalytic activity, acting on a protein small molecule sensor activity kinase activity protein kinase activity transferase activity phosphotransferase activity, nitrogenous group as acceptor phosphotransferase activity, alcohol group as acceptor protein histidine kinase activity transferase activity, transferring phosphorus-containing groups phosphorelay sensor kinase activity catalytic activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ethylene binding alkene binding cation binding metal ion binding molecular transducer activity ethylene receptor activity signaling receptor activity identical protein binding protein binding	regulation of stomatal movement regulation of biological process regulation of cellular process stomatal movement biological regulation cellular process amine metabolic process organonitrogen compound metabolic process organic substance metabolic process cytokinin metabolic process regulation of hormone levels metabolic process regulation of biological quality hormone metabolic process regulation of stomatal movement regulation of biological process regulation of cellular process stomatal movement biological regulation cellular process amine metabolic process organonitrogen compound metabolic process organic substance metabolic process cytokinin metabolic process regulation of hormone levels metabolic process regulation of biological quality hormone metabolic process cellular response to stimulus response to organic substance response to stimulus signaling response to oxygen-containing compound cellular response to oxygen-containing compound cell communication sugar mediated signaling pathway cellular response to carbohydrate stimulus cellular response to chemical stimulus response to carbohydrate response to chemical cellular response to organic substance signal transduction carbohydrate mediated signaling cell division response to gibberellin response to lipid response to hormone response to endogenous stimulus developmental process multicellular organismal process reproductive system development reproductive process multicellular organismal reproductive process developmental maturation developmental process involved in reproduction seed dormancy process multicellular organism development fruit development seed development anatomical structure development reproductive structure development post-embryonic development dormancy process seed maturation system development phloem or xylem histogenesis tissue development regulation of multicellular organismal development regulation of developmental process regulation of seedling development seedling development regulation of post-embryonic development regulation of multicellular organismal process biological process involved in interspecies interaction between organisms response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus detection of hormone stimulus detection of ethylene stimulus detection of stimulus detection of chemical stimulus detection of endogenous stimulus response to ethylene response to insect response to auxin reactive oxygen species biosynthetic process biosynthetic process cellular biosynthetic process cellular metabolic process reactive oxygen species metabolic process hydrogen peroxide metabolic process hydrogen peroxide biosynthetic process negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction hormone-mediated signaling pathway intracellular signal transduction negative regulation of cell communication regulation of phosphorelay signal transduction system regulation of ethylene-activated signaling pathway cellular response to endogenous stimulus regulation of intracellular signal transduction ethylene-activated signaling pathway negative regulation of cellular process cellular response to hormone stimulus regulation of signaling phosphorelay signal transduction system negative regulation of phosphorelay signal transduction system negative regulation of response to stimulus cellular response to ethylene stimulus negative regulation of ethylene-activated signaling pathway negative regulation of signal transduction regulation of response to stimulus regulation of cell communication response to abscisic acid response to alcohol response to heat response to abiotic stimulus response to temperature stimulus defense response by callose deposition cellular localization cell wall organization or biogenesis cell wall organization cellular component organization polysaccharide localization localization cell wall thickening callose localization cellular response to stress cellular macromolecule localization cellular component organization or biogenesis defense response by callose deposition in cell wall cell wall modification callose deposition in cell wall defense response by cell wall thickening macromolecule localization external encapsulating structure organization response to osmotic stress response to salt stress response to molecule of bacterial origin	membrane-bounded organelle intracellular anatomical structure organelle subcompartment membrane cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane membrane-bounded organelle intracellular anatomical structure organelle subcompartment membrane cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011006	CheY-like superfamily	Homologous Superfamily
A	IPR003594	Histidine kinase/HSP90-like ATPase	Domain
A	IPR014525	Ethylene receptor	Family
A	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
A	IPR003661	Signal transduction histidine kinase, dimerisation/phosphoacceptor domain	Domain
A	IPR003018	GAF domain	Domain
A	IPR004358	Signal transduction histidine kinase-related protein, C-terminal	Domain
A	IPR001789	Signal transduction response regulator, receiver domain	Domain
A	IPR036097	Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily	Homologous Superfamily
A	IPR005467	Histidine kinase domain	Domain
A	IPR029016	GAF-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.