Annotations: 4PKE

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF12166	e4pkeA1	A: beta sandwiches	X: Piezo CTL2 domain (From Topology)	H: Piezo CTL2 domain (From Topology)	T: Piezo CTL2 domain	F: PF12166	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF12166	Piezo non-specific cation channel, R-Ras-binding domain (Piezo_RRas_bdg)	Piezo non-specific cation channel, R-Ras-binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Protein C10C5.1, isoform i	monoatomic cation transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity gated channel activity mechanosensitive monoatomic ion channel activity	response to stimulus response to mechanical stimulus response to abiotic stimulus response to external stimulus cellular response to stimulus cellular process cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus biological regulation regulation of biological quality regulation of membrane potential monoatomic cation transmembrane transport response to stimulus response to mechanical stimulus response to abiotic stimulus response to external stimulus cellular response to stimulus cellular process cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus biological regulation regulation of biological quality regulation of membrane potential monoatomic cation transmembrane transport transmembrane transport localization transport monoatomic ion transmembrane transport monoatomic ion transport monoatomic cation transport establishment of localization detection of external stimulus detection of stimulus detection of mechanical stimulus detection of abiotic stimulus multicellular organismal process regulation of biological process ovulation sexual reproduction regulation of reproductive process reproductive process multicellular organismal reproductive process positive regulation of biological process female gamete generation gamete generation regulation of ovulation positive regulation of multicellular organismal process regulation of multicellular organismal process positive regulation of ovulation positive regulation of reproductive process multi-multicellular organism process positive regulation of brood size regulation of brood size sperm motility cilium movement involved in cell motility cilium or flagellum-dependent cell motility cilium-dependent cell motility flagellated sperm motility microtubule-based movement microtubule-based process cilium movement cell motility	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR031805	Piezo domain	Domain
A	IPR027272	Piezo family	Family
A	IPR031334	Piezo non-specific cation channel, R-Ras-binding domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.