4PJW

crystal structure of human Stromal Antigen 2 (SA2) in complex with Sister Chromatid Cohesion protein 1 (Scc1), with bound MES

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08514,PF21581	e4pjwA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF08514,PF21581	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF21581	Stromalin conservative domain (SCD)	Stromalin conservative domain	-	Repeat
A	PF08514	STAG domain (STAG)	STAG domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Cohesin subunit SA-2	protein-containing complex binding chromatin binding binding	cellular process cell division non-membrane-bounded organelle assembly microtubule cytoskeleton organization mitotic cell cycle cellular component organization cellular component biogenesis cellular component assembly mitotic sister chromatid segregation cell cycle cellular component organization or biogenesis chromosome segregation microtubule cytoskeleton organization involved in mitosis spindle organization cellular process cell division non-membrane-bounded organelle assembly microtubule cytoskeleton organization mitotic cell cycle cellular component organization cellular component biogenesis cellular component assembly mitotic sister chromatid segregation cell cycle cellular component organization or biogenesis chromosome segregation microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process mitotic nuclear division organelle assembly organelle fission chromosome organization sister chromatid segregation spindle assembly mitotic spindle organization mitotic spindle assembly organelle organization nuclear division mitotic cell cycle process nuclear chromosome segregation microtubule-based process cytoskeleton organization sister chromatid cohesion sexual reproduction reproductive process meiotic cell cycle mitotic sister chromatid cohesion establishment of mitotic sister chromatid cohesion establishment of sister chromatid cohesion	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix nucleolus membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix nucleolus intracellular non-membrane-bounded organelle non-membrane-bounded organelle membrane chromosome cytoplasm cytosol fibrillar center chromosome, centromeric region chromosomal region protein-containing complex cohesin complex mitotic spindle spindle cytoskeleton mitotic spindle pole spindle pole microtubule cytoskeleton mitotic cohesin complex nucleoplasm protein-DNA complex chromatin
B	Double-strand-break repair protein rad21 homolog	RNA binding binding organic cyclic compound binding lncRNA binding nucleic acid binding protein-containing complex binding chromatin binding DNA binding transcription factor binding protein binding DNA-binding transcription factor binding	cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process replication-born double-strand break repair via sister chromatid exchange cellular response to stress DNA damage response response to stress cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process replication-born double-strand break repair via sister chromatid exchange cellular response to stress DNA damage response response to stress recombinational repair metabolic process cellular process macromolecule metabolic process double-strand break repair via homologous recombination DNA repair multicellular organismal process regulation of tumor necrosis factor production regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process negative regulation of tumor necrosis factor production cytokine production organic substance biosynthetic process regulation of cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation tumor necrosis factor superfamily cytokine production regulation of cellular metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process tumor necrosis factor production negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression regulation of tumor necrosis factor superfamily cytokine production biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of tumor necrosis factor superfamily cytokine production regulation of macromolecule biosynthetic process negative regulation of multicellular organismal process regulation of metabolic process homologous recombination sexual reproduction reproductive process meiotic cell cycle process cellular component organization meiosis I meiotic nuclear division cell cycle cellular component organization or biogenesis reciprocal homologous recombination cell cycle process meiotic cell cycle organelle fission reciprocal meiotic recombination nuclear division organelle organization meiosis I cell cycle process cell division regulation of cell cycle phase transition G2/M transition of mitotic cell cycle negative regulation of cell cycle cell cycle phase transition mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle negative regulation of cell cycle phase transition regulation of cell cycle cell cycle G2/M phase transition negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process regulation of cell cycle G2/M phase transition negative regulation of cell cycle process regulation of mitotic cell cycle phase transition mitotic cell cycle process negative regulation of cell cycle G2/M phase transition negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition chromosome segregation protein localization localization protein localization to chromatin cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization apoptotic process cell death programmed cell death interleukin-1 production regulation of interleukin-1 beta production negative regulation of interleukin-1 beta production negative regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production chromosome organization sister chromatid cohesion positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization positive regulation of biological process positive regulation of cell cycle process positive regulation of cellular process regulation of chromosome organization positive regulation of sister chromatid cohesion regulation of organelle organization positive regulation of cell cycle positive regulation of chromosome organization regulation of sister chromatid cohesion mitotic sister chromatid cohesion establishment of mitotic sister chromatid cohesion establishment of sister chromatid cohesion neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process regulation of neuron apoptotic process protein-DNA complex organization chromatin looping protein-containing complex organization chromatin organization interleukin-10 production positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of interleukin-10 production positive regulation of interleukin-10 production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production positive regulation of cellular biosynthetic process response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus establishment of meiotic sister chromatid cohesion meiotic sister chromatid cohesion regulation of glial cell apoptotic process negative regulation of glial cell apoptotic process glial cell apoptotic process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription regulation of mitotic nuclear division negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization mitotic sister chromatid separation negative regulation of sister chromatid segregation negative regulation of cellular component organization sister chromatid segregation regulation of mitotic sister chromatid segregation regulation of chromosome separation negative regulation of mitotic nuclear division regulation of chromosome segregation regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle regulation of mitotic metaphase/anaphase transition mitotic sister chromatid segregation negative regulation of mitotic metaphase/anaphase transition negative regulation of chromosome separation mitotic nuclear division negative regulation of chromosome segregation chromosome separation negative regulation of organelle organization negative regulation of nuclear division regulation of sister chromatid segregation negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle	midbody cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix midbody cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix cytoskeleton spindle intracellular non-membrane-bounded organelle spindle pole microtubule cytoskeleton non-membrane-bounded organelle membrane condensed nuclear chromosome nuclear chromosome chromosome condensed chromosome cytoplasm cytosol chromosome, centromeric region chromosomal region protein-containing complex mitotic cohesin complex cohesin complex nucleoplasm protein-DNA complex chromatin meiotic cohesin complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR039662	Cohesin subunit Scc3/SA	Family
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR020839	Stromalin conservative domain	Domain
A	IPR013721	STAG	Domain
B	IPR023093	ScpA-like, C-terminal	Homologous Superfamily
B	IPR049589	NXP-1, middle HEAT-repeat binding domain	Domain
B	IPR039781	Rad21/Rec8-like protein	Family
B	IPR006910	Rad21/Rec8-like protein, N-terminal	Domain
B	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
B	IPR006909	Rad21/Rec8-like protein, C-terminal, eukaryotic	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8N3U4	urinary bladder cancer myeloid leukemia transitional cell carcinoma myelodysplastic syndrome chronic monocytic leukemia glioblastoma Leukemia, Megakaryoblastic, of Down Syndrome large cell medulloblastoma lymphoplasmacytic lymphoma malignant mesothelioma Alzheimer disease bladder benign neoplasm ovarian cancer pilocytic astrocytoma psoriasis urinary bladder cancer myeloid leukemia transitional cell carcinoma myelodysplastic syndrome chronic monocytic leukemia glioblastoma Leukemia, Megakaryoblastic, of Down Syndrome large cell medulloblastoma lymphoplasmacytic lymphoma malignant mesothelioma Alzheimer disease bladder benign neoplasm ovarian cancer pilocytic astrocytoma psoriasis Down syndrome holoprosencephaly leukemia malignant ependymoma medulloblastoma astrocytic tumor oligodendroglioma bladder carcinoma in situ pancreatic ductal adenocarcinoma plasma cell myeloma congenital anemia rheumatoid arthritis dermatomyositis urinary bladder carcinoma Emery-Dreifuss muscular dystrophy glioma juvenile dermatomyositis malignant glioma melanoma myopathy atypical teratoid rhabdoid tumor osteosarcoma breast cancer Pick disease primitive neuroectodermal tumor cutaneous melanoma diabetes mellitus urinary bladder neoplasm Ewing sarcoma
B	Pharos: O60216	Cornelia de Lange syndrome myeloid leukemia Leukemia, Megakaryoblastic, of Down Syndrome Cornelia de Lange syndrome 4 chronic monocytic leukemia intellectual disability lung carcinoma malignant mesothelioma medulloblastoma acute myeloid leukemia oligodendroglioma breast cancer colorectal adenoma rheumatoid arthritis endometrium carcinoma in situ Cornelia de Lange syndrome myeloid leukemia Leukemia, Megakaryoblastic, of Down Syndrome Cornelia de Lange syndrome 4 chronic monocytic leukemia intellectual disability lung carcinoma malignant mesothelioma medulloblastoma acute myeloid leukemia oligodendroglioma breast cancer colorectal adenoma rheumatoid arthritis endometrium carcinoma in situ invasive ductal breast carcinoma lung adenocarcinoma Mungan syndrome astrocytic tumor osteosarcoma primitive neuroectodermal tumor Roberts syndrome colorectal cancer Cornelia de Lange syndrome 2 glioblastoma large cell medulloblastoma lung cancer malignant ependymoma atypical teratoid rhabdoid tumor plasma cell myeloma colorectal adenocarcinoma trichorhinophalangeal syndrome type II congenital anemia Cornelia de Lange syndrome 3 endometrial carcinoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.