4PJ2

Crystal structure of Aeromonas hydrophila PliI in complex with Meretrix lusoria lysozyme

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PliI-like	8092831	3002628	SCOP2B (2022-06-29)
B	SCOP2 Family	PliI-like	8046082	4004865	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	PliI-like	8092831	3002628	SCOP2 (2022-06-29)
C	SCOP2 Family	I-type lysozyme-like	8047289	4005551	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Lysozyme-like	8092832	3001879	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Lysozyme-like	8092832	3001879	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF16743	e4pj2A1	A: beta duplicates or obligate multimers	X: periplasmic lysozyme inhibitor of I-type lysozyme-like	H: periplasmic lysozyme inhibitor of I-type lysozyme (From Topology)	T: periplasmic lysozyme inhibitor of I-type lysozyme	F: PF16743	ECOD (1.6)
B	PF16743	e4pj2B1	A: beta duplicates or obligate multimers	X: periplasmic lysozyme inhibitor of I-type lysozyme-like	H: periplasmic lysozyme inhibitor of I-type lysozyme (From Topology)	T: periplasmic lysozyme inhibitor of I-type lysozyme	F: PF16743	ECOD (1.6)
C	PF05497	e4pj2C1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: PF05497	ECOD (1.6)
D	PF05497	e4pj2D1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: PF05497	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.128.460	Mainly Beta	Beta Barrel	Lipocalin	Periplasmic lysozyme inhibitor of I-type lysozyme	CATH (4.3.0)
B	2.40.128.460	Mainly Beta	Beta Barrel	Lipocalin	Periplasmic lysozyme inhibitor of I-type lysozyme	CATH (4.3.0)
C	1.10.530.10	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)
D	1.10.530.10	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF16743	Periplasmic lysozyme inhibitor of I-type lysozyme (PliI)	Periplasmic lysozyme inhibitor of I-type lysozyme	-	Domain
C, D	PF05497	Destabilase (Destabilase)	Destabilase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Putative exported protein	cation binding ion binding binding metal ion binding small molecule binding	-	-
C, D	Lysozyme	hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity hydrolase activity catalytic activity chitinase activity	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus cellular process disruption of cell in another organism disruption of anatomical structure in another organism biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus cellular process disruption of cell in another organism disruption of anatomical structure in another organism killing of cells of another organism cell killing metabolic process	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR031948	Periplasmic lysozyme inhibitor, I-type	Family
A, B	IPR038643	PliI superfamily	Homologous Superfamily
C, D	IPR008597	Invertebrate-type lysozyme	Family
C, D	IPR023346	Lysozyme-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.