4PHQ

ClyA CC6/264 ox (6-303)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4phqa_	Coiled coil proteins	Antiparallel coiled-coil	Bacterial hemolysins	Hemolysin E (HlyE, ClyA, SheA)	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
B	d4phqb_	Coiled coil proteins	Antiparallel coiled-coil	Bacterial hemolysins	Hemolysin E (HlyE, ClyA, SheA)	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
C	d4phqc_	Coiled coil proteins	Antiparallel coiled-coil	Bacterial hemolysins	Hemolysin E (HlyE, ClyA, SheA)	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
D	d4phqd_	Coiled coil proteins	Antiparallel coiled-coil	Bacterial hemolysins	Hemolysin E (HlyE, ClyA, SheA)	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Bacterial hemolysins	8039660	3001673	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Bacterial hemolysins	8039660	3001673	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Bacterial hemolysins	8039660	3001673	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Bacterial hemolysins	8039660	3001673	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF06109	e4phqA1	A: alpha bundles	X: Bacterial hemolysins-like	H: Bacterial hemolysins (From Topology)	T: Bacterial hemolysins	F: PF06109	ECOD (1.6)
B	PF06109	e4phqB1	A: alpha bundles	X: Bacterial hemolysins-like	H: Bacterial hemolysins (From Topology)	T: Bacterial hemolysins	F: PF06109	ECOD (1.6)
C	PF06109	e4phqC1	A: alpha bundles	X: Bacterial hemolysins-like	H: Bacterial hemolysins (From Topology)	T: Bacterial hemolysins	F: PF06109	ECOD (1.6)
D	PF06109	e4phqD1	A: alpha bundles	X: Bacterial hemolysins-like	H: Bacterial hemolysins (From Topology)	T: Bacterial hemolysins	F: PF06109	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1170.10	Mainly Alpha	Up-down Bundle	Hemolysin E	Chain: A	CATH (4.3.0)
B	1.20.1170.10	Mainly Alpha	Up-down Bundle	Hemolysin E	Chain: A	CATH (4.3.0)
C	1.20.1170.10	Mainly Alpha	Up-down Bundle	Hemolysin E	Chain: A	CATH (4.3.0)
D	1.20.1170.10	Mainly Alpha	Up-down Bundle	Hemolysin E	Chain: A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF06109	Haemolysin E (HlyE) (HlyE)	Haemolysin E (HlyE)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Hemolysin E, chromosomal	identical protein binding protein binding binding toxin activity	hemolysis in another organism biological process involved in interspecies interaction between organisms cytolysis in another organism cellular process disruption of cell in another organism disruption of anatomical structure in another organism cytolysis killing of cells of another organism cell killing regulation of biological process modulation of apoptotic process in another organism regulation of cellular process regulation of apoptotic process biological regulation hemolysis in another organism biological process involved in interspecies interaction between organisms cytolysis in another organism cellular process disruption of cell in another organism disruption of anatomical structure in another organism cytolysis killing of cells of another organism cell killing regulation of biological process modulation of apoptotic process in another organism regulation of cellular process regulation of apoptotic process biological regulation regulation of killing of cells of another organism regulation of programmed cell death cell death regulation of cell killing apoptotic process modulation of process of another organism programmed cell death	membrane cellular anatomical entity host cell plasma membrane host cellular component host cell part host cell membrane periplasmic space extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR027018	Hemolysin E	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.