4P7H

Structure of Human beta-Cardiac Myosin Motor Domain::GFP chimera

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	GFP-like	8096046	3000576	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	GFP-like	8096046	3000576	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01353	e4p7hA3	A: beta barrels	X: GFP-like (From Topology)	H: GFP-like (From Topology)	T: GFP-like	F: PF01353	ECOD (1.6)
A	PF02736	e4p7hA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF02736	ECOD (1.6)
A	PF00063	e4p7hA2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00063	ECOD (1.6)
B	PF01353	e4p7hB2	A: beta barrels	X: GFP-like (From Topology)	H: GFP-like (From Topology)	T: GFP-like	F: PF01353	ECOD (1.6)
B	PF02736	e4p7hB3	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF02736	ECOD (1.6)
B	PF00063	e4p7hB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00063	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02736	Myosin N-terminal SH3-like domain (Myosin_N)	Myosin N-terminal SH3-like domain	This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.	Domain
A, B	PF00063	Myosin head (motor domain) (Myosin_head)	Myosin head (motor domain)	-	Domain
A, B	PF01353	Green fluorescent protein (GFP)	Green fluorescent protein	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Myosin-7,Green fluorescent protein	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding calmodulin binding cytoskeletal motor activity microfilament motor activity ATP-dependent activity	bioluminescence cellular metabolic process metabolic process cellular process generation of precursor metabolites and energy heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation bioluminescence cellular metabolic process metabolic process cellular process generation of precursor metabolites and energy heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process regulation of biological quality heart contraction blood circulation regulation of heart rate muscle contraction muscle system process striated muscle contraction ribose phosphate metabolic process ATP metabolic process carbohydrate derivative metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process organic substance metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process purine nucleoside triphosphate metabolic process organonitrogen compound metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process organic cyclic compound metabolic process organophosphate metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process regulation of the force of heart contraction regulation of muscle adaptation striated muscle adaptation response to stimulus transition between fast and slow fiber regulation of skeletal muscle adaptation regulation of muscle system process muscle adaptation regulation of response to stimulus skeletal muscle adaptation slow-twitch skeletal muscle fiber contraction twitch skeletal muscle contraction multicellular organismal movement musculoskeletal movement regulation of twitch skeletal muscle contraction regulation of skeletal muscle contraction regulation of slow-twitch skeletal muscle fiber contraction nervous system process neuromuscular process skeletal muscle contraction voluntary skeletal muscle contraction regulation of striated muscle contraction regulation of muscle contraction muscle filament sliding actin filament-based process actin-mediated cell contraction actin filament-based movement actin-myosin filament sliding cardiac muscle contraction developmental process heart development multicellular organism development anatomical structure development animal organ development adult heart development circulatory system development system development ventricular cardiac muscle tissue morphogenesis heart morphogenesis striated muscle tissue development muscle structure development ventricular cardiac muscle tissue development cardiac chamber development animal organ morphogenesis muscle tissue development muscle organ development cardiac chamber morphogenesis cardiac muscle tissue development tissue development muscle tissue morphogenesis anatomical structure morphogenesis tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis cardiac ventricle development muscle organ morphogenesis regulation of the force of skeletal muscle contraction regulation of skeletal muscle contraction by chemo-mechanical energy conversion cellular developmental process cellular component assembly involved in morphogenesis non-membrane-bounded organelle assembly cell development muscle cell differentiation cellular component organization cellular component biogenesis striated muscle cell development cellular anatomical entity morphogenesis cellular component assembly muscle cell development cell differentiation sarcomere organization cellular component organization or biogenesis actomyosin structure organization actin cytoskeleton organization organelle assembly myofibril assembly organelle organization anatomical structure formation involved in morphogenesis striated muscle cell differentiation supramolecular fiber organization cytoskeleton organization muscle hypertrophy striated muscle hypertrophy cardiac muscle adaptation response to stress cardiac muscle hypertrophy cardiac muscle hypertrophy in response to stress muscle hypertrophy in response to stress	intracellular anatomical structure cellular anatomical entity Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex intracellular anatomical structure cellular anatomical entity Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle protein-containing complex actin cytoskeleton myosin complex cytoskeleton myosin II complex muscle myosin complex myosin filament actin filament bundle actomyosin stress fiber contractile actin filament bundle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000786	Green fluorescent protein, GFP	Family
A, B	IPR011584	Green fluorescent protein-related	Family
A, B	IPR009017	Green fluorescent protein	Homologous Superfamily
A, B	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A, B	IPR000048	IQ motif, EF-hand binding site	Binding Site
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR014751	DNA repair protein XRCC4-like, C-terminal	Homologous Superfamily
A, B	IPR001609	Myosin head, motor domain	Domain
A, B	IPR002928	Myosin tail	Domain
A, B	IPR004009	Myosin, N-terminal, SH3-like	Domain
A, B	IPR008989	Myosin S1 fragment, N-terminal	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P12883	myopathy, myosin storage, autosomal dominant dilated cardiomyopathy myopathy, myosin storage, autosomal recessive hypertrophic cardiomyopathy left ventricular noncompaction congenital fiber-type disproportion myopathy dilated cardiomyopathy 1S MYH7-related skeletal myopathy distal myopathy Ebstein anomaly hypertrophic cardiomyopathy 1 cardiomyopathy myocardial infarction tibial muscular dystrophy congenital structural myopathy myopathy, myosin storage, autosomal dominant dilated cardiomyopathy myopathy, myosin storage, autosomal recessive hypertrophic cardiomyopathy left ventricular noncompaction congenital fiber-type disproportion myopathy dilated cardiomyopathy 1S MYH7-related skeletal myopathy distal myopathy Ebstein anomaly hypertrophic cardiomyopathy 1 cardiomyopathy myocardial infarction tibial muscular dystrophy congenital structural myopathy atrial fibrillation MYH7-related late-onset scapuloperoneal muscular dystrophy centronuclear myopathy coronary stenosis familial dilated cardiomyopathy heart disease arthrogryposis LEFT VENTRICULAR NONCOMPACTION 5 autosomal dominant centronuclear myopathy scapuloperoneal myopathy Charcot-Marie-Tooth disease familial hypertrophic cardiomyopathy hyaline body myopathy malignant ependymoma psoriasis X-linked centronuclear myopathy dilated cardiomyopathy 1A familial isolated dilated cardiomyopathy autosomal recessive centronuclear myopathy myopathy myotonia congenita restrictive cardiomyopathy tubular aggregate myopathy X-linked Emery-Dreifuss muscular dystrophy

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.