4P3W

Crystal structure of the human filamin A Ig-like domains 20-21 in complex with migfilin peptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	E set domains	8055043	3000070	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	E set domains	8055043	3000070	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	E set domains	8055043	3000070	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	E set domains	8055043	3000070	SCOP2B (2022-06-29)
I [auth D]	SCOP2B Superfamily	E set domains	8055043	3000070	SCOP2B (2022-06-29)
J [auth C]	SCOP2B Superfamily	E set domains	8055043	3000070	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Filamin	e4p3wA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Filamin	ECOD (1.6)
B	Filamin	e4p3wB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Filamin	ECOD (1.6)
E	Filamin	e4p3wE2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Filamin	ECOD (1.6)
F	Filamin	e4p3wF2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Filamin	ECOD (1.6)
I [auth D]	Filamin	e4p3wD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Filamin	ECOD (1.6)
J [auth C]	Filamin	e4p3wC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Filamin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
F	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
I [auth D]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
J [auth C]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, E, F, I [auth D], A, B, E, F, I [auth D], J [auth C]	PF00630	Filamin/ABP280 repeat (Filamin)	Filamin/ABP280 repeat	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, E, F, I [auth D], A, B, E, F, I [auth D], J [auth C]	Filamin-A	small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding cell adhesion molecule binding cadherin binding potassium channel regulator activity channel regulator activity ion channel regulator activity small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding cell adhesion molecule binding cadherin binding potassium channel regulator activity channel regulator activity ion channel regulator activity molecular function regulator activity transporter regulator activity signaling receptor binding immunoglobulin receptor binding Fc-gamma receptor I complex binding RNA binding organic cyclic compound binding nucleic acid binding kinase binding transmembrane transporter binding identical protein binding protein homodimerization activity protein dimerization activity SMAD binding transcription factor binding DNA-binding transcription factor binding protein kinase C binding protein kinase binding G protein-coupled receptor binding	cellular response to stimulus multicellular organismal process regulation of cellular process response to stimulus cell projection organization positive regulation of neuron projection regeneration regulation of cellular response to stress neuron projection development regeneration neuron projection regeneration positive regulation of developmental process multicellular organism development neuron differentiation cell differentiation anatomical structure development cellular response to stimulus multicellular organismal process regulation of cellular process response to stimulus cell projection organization positive regulation of neuron projection regeneration regulation of cellular response to stress neuron projection development regeneration neuron projection regeneration positive regulation of developmental process multicellular organism development neuron differentiation cell differentiation anatomical structure development positive regulation of cell projection organization response to wounding system development positive regulation of response to wounding developmental process regulation of biological process regulation of axon regeneration regulation of cell projection organization response to external stimulus nervous system development generation of neurons regulation of response to stimulus regulation of neuron projection regeneration regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization regulation of developmental process cellular developmental process regulation of response to external stimulus positive regulation of biological process cell development response to axon injury regulation of response to wounding positive regulation of response to stimulus cellular component organization neurogenesis positive regulation of response to external stimulus cellular response to stress axon regeneration positive regulation of neuron projection development response to stress regulation of response to stress cellular component organization or biogenesis positive regulation of cellular process plasma membrane bounded cell projection organization biological regulation axon development neuron development cellular process positive regulation of axon regeneration regulation of plasma membrane bounded cell projection organization regulation of protein stability regulation of biological quality protein stabilization cardiac muscle cell membrane repolarization regulation of action potential regulation of membrane repolarization during action potential membrane repolarization membrane repolarization during cardiac muscle cell action potential regulation of cardiac muscle cell membrane repolarization action potential membrane repolarization during action potential regulation of membrane repolarization during cardiac muscle cell action potential regulation of membrane repolarization cardiac muscle cell action potential regulation of membrane potential regulation of body fluid levels wound healing homotypic cell-cell adhesion cell activation hemostasis platelet aggregation blood coagulation cell adhesion cell-cell adhesion coagulation platelet activation protein localization localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane positive regulation of substrate adhesion-dependent cell spreading regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of substrate adhesion-dependent cell spreading regulation of cell adhesion cell-substrate adhesion positive regulation of cell-substrate adhesion substrate adhesion-dependent cell spreading organelle organization actin cytoskeleton organization actin filament-based process cytoskeleton organization negative regulation of biological process negative regulation of cellular process negative regulation of cell projection organization negative regulation of cellular component organization negative regulation of neuron projection development regulation of cell motility regulation of locomotion regulation of cell migration cell migration cell motility locomotion regulation of localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization import into nucleus establishment of localization in cell regulation of intracellular transport positive regulation of protein localization to nucleus organic substance transport positive regulation of protein import into nucleus intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus establishment of localization establishment of protein localization to organelle positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport regulation of protein localization transport positive regulation of nucleocytoplasmic transport regulation of protein localization to nucleus positive regulation of protein transport regulation of protein import into nucleus protein import into nucleus positive regulation of intracellular transport regulation of transport regulation of establishment of protein localization regulation of protein transport positive regulation of transport regulation of cellular localization protein transport protein localization to organelle heart development heart morphogenesis animal organ development circulatory system development anatomical structure morphogenesis animal organ morphogenesis head development forebrain development brain development pallium development cerebral cortex development central nervous system development telencephalon development system process regulation of heart contraction regulation of system process cell-cell signaling involved in cardiac conduction cardiac muscle contraction cell communication circulatory system process cell communication involved in cardiac conduction cardiac muscle cell contraction muscle contraction regulation of blood circulation heart process cardiac muscle cell action potential involved in contraction signaling atrial cardiac muscle cell to AV node cell signaling regulation of atrial cardiac muscle cell membrane repolarization striated muscle contraction membrane repolarization during atrial cardiac muscle cell action potential regulation of multicellular organismal process regulation of membrane repolarization during atrial cardiac muscle cell action potential atrial cardiac muscle cell to AV node cell communication blood circulation atrial cardiac muscle cell action potential cell-cell signaling actin filament-based movement muscle system process atrial cardiac muscle cell membrane repolarization cardiac conduction actin-mediated cell contraction heart contraction positive regulation of cell communication regulation of integrin-mediated signaling pathway positive regulation of signal transduction regulation of signal transduction positive regulation of integrin-mediated signaling pathway signal transduction regulation of signaling integrin-mediated signaling pathway cell surface receptor signaling pathway regulation of cell communication positive regulation of signaling mesenchyme development mesenchymal cell differentiation tissue development epithelial to mesenchymal transition reproductive process sex differentiation developmental process involved in reproduction epithelial cell differentiation Sertoli cell differentiation male gonad development male sex differentiation development of primary male sexual characteristics development of primary sexual characteristics reproductive structure development epithelium development gonad development reproductive system development Sertoli cell development establishment of Sertoli cell barrier epithelial cell development mRNA transcription by RNA polymerase II cellular biosynthetic process RNA metabolic process mRNA transcription nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process organic substance metabolic process transcription by RNA polymerase II organic substance biosynthetic process cellular metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process metabolic process macromolecule metabolic process actin filament organization actin crosslink formation supramolecular fiber organization catabolic process macromolecule catabolic process negative regulation of protein catabolic process regulation of primary metabolic process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound catabolic process negative regulation of catabolic process organonitrogen compound metabolic process regulation of protein metabolic process negative regulation of metabolic process protein catabolic process regulation of macromolecule metabolic process regulation of catabolic process organic substance catabolic process regulation of metabolic process regulation of protein catabolic process receptor clustering cell population proliferation positive regulation of cell population proliferation positive regulation of neural precursor cell proliferation regulation of cell population proliferation neural precursor cell proliferation regulation of neural precursor cell proliferation positive regulation of canonical NF-kappaB signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction hemopoiesis megakaryocyte differentiation myeloid cell differentiation megakaryocyte development myeloid cell development negative regulation of DNA-binding transcription factor activity regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process negative regulation of molecular function regulation of cellular metabolic process regulation of cellular biosynthetic process regulation of molecular function regulation of gene expression regulation of DNA-binding transcription factor activity regulation of macromolecule biosynthetic process regulation of DNA-templated transcription blood vessel morphogenesis tube development angiogenesis vasculature development tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death protein localization to cell surface positive regulation of locomotion regulation of neuron migration positive regulation of cell migration positive regulation of cell motility neuron migration positive regulation of neuron migration macromolecule deacylation protein deacetylation protein deacylation tubulin deacetylation macromolecule modification protein modification process cell morphogenesis formation of radial glial scaffolds hindbrain radial glia guided cell migration hindbrain development cell migration in hindbrain maintenance of protein location cytoplasmic sequestering of protein maintenance of location cell junction organization synapse organization adenylate cyclase-inhibiting dopamine receptor signaling pathway cellular response to nitrogen compound response to dopamine response to organic substance dopamine receptor signaling pathway cellular response to dopamine response to monoamine cellular response to endogenous stimulus response to catecholamine cellular response to catecholamine stimulus cellular response to organic substance response to organic cyclic compound response to organonitrogen compound response to endogenous stimulus cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway cellular response to chemical stimulus cellular response to organonitrogen compound cellular response to monoamine stimulus response to chemical adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway organelle assembly plasma membrane bounded cell projection assembly cellular component biogenesis cellular component assembly cilium assembly cilium organization cell projection assembly positive regulation of organelle organization regulation of cytoskeleton organization regulation of actin filament-based process regulation of actin filament bundle assembly positive regulation of actin filament bundle assembly actin filament bundle organization regulation of actin filament organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization positive regulation of supramolecular fiber organization regulation of cellular component biogenesis regulation of organelle organization actin filament bundle assembly regulation of actin cytoskeleton organization regulation of supramolecular fiber organization semaphorin-plexin signaling pathway blood vessel remodeling tissue remodeling inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process monoatomic ion transmembrane transport calcium ion homeostasis negative regulation of sequestering of calcium ion calcium ion transport metal ion transport maintenance of location in cell monoatomic cation transmembrane transport intracellular monoatomic cation homeostasis monoatomic ion homeostasis monoatomic ion transport intracellular chemical homeostasis monoatomic cation homeostasis monoatomic cation transport regulation of sequestering of calcium ion intracellular monoatomic ion homeostasis calcium ion transmembrane import into cytosol sequestering of calcium ion inorganic ion transmembrane transport inorganic cation transmembrane transport transmembrane transport release of sequestered calcium ion into cytosol cellular homeostasis chemical homeostasis calcium ion transmembrane transport non-membrane-bounded organelle assembly microtubule cytoskeleton organization mitotic cell cycle mitotic sister chromatid segregation cell cycle chromosome segregation microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process mitotic nuclear division organelle fission chromosome organization sister chromatid segregation spindle assembly mitotic spindle organization mitotic spindle assembly nuclear division mitotic cell cycle process nuclear chromosome segregation microtubule-based process protein maturation blood coagulation, intrinsic pathway blood coagulation, fibrin clot formation protein activation cascade regulation of cell activation positive regulation of platelet activation positive regulation of cell activation regulation of platelet activation positive regulation of multicellular organismal process protein localization to bicellular tight junction protein localization to cell junction protein localization to cell-cell junction morphogenesis of an epithelium epiboly involved in wound healing morphogenesis of an epithelial sheet tissue morphogenesis epiboly wound healing, spreading of cells vesicle-mediated transport endosomal transport vesicle-mediated transport between endosomal compartments early endosome to late endosome transport positive regulation of cation transmembrane transport regulation of potassium ion transport potassium ion transmembrane transport regulation of monoatomic ion transmembrane transport positive regulation of monoatomic ion transport positive regulation of transmembrane transport positive regulation of monoatomic ion transmembrane transport regulation of metal ion transport regulation of monoatomic ion transport regulation of potassium ion transmembrane transport positive regulation of potassium ion transport regulation of transmembrane transport positive regulation of potassium ion transmembrane transport potassium ion transport regulation of monoatomic cation transmembrane transport cell-cell junction organization negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase I negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of transcription by RNA polymerase I negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of transcription by RNA polymerase I negative regulation of biosynthetic process	somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity membrane intracellular anatomical structure Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity membrane intracellular anatomical structure Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle cell-cell junction anchoring junction cell junction extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoskeleton actin cytoskeleton cytosol cluster of actin-based cell projections brush border synapse glutamatergic synapse Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system trans-Golgi network cell projection dendrite dendritic tree neuron projection dendritic shaft plasma membrane bounded cell projection perinuclear region of cytoplasm polymeric cytoskeletal fiber actin filament postsynapse cell cortex cortical cytoskeleton cell periphery focal adhesion cell-substrate junction nucleus membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen nuclear lumen growth cone axon distal axon axonal growth cone site of polarized growth plasma membrane actin filament bundle protein-containing complex plasma membrane protein complex membrane protein complex glycoprotein Ib-IX-V complex receptor complex glycoprotein complex plasma membrane signaling receptor complex nuclear protein-containing complex Myb complex apical dendrite
C [auth G], D [auth H], G [auth K], H [auth L], K [auth J], C [auth G], D [auth H], G [auth K], H [auth L], K [auth J], L [auth I]	Filamin-binding LIM protein 1	cytoskeletal protein binding protein binding binding filamin binding cation binding ion binding metal ion binding small molecule binding	developmental process regulation of biological process regulation of developmental process biological regulation regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis anatomical structure development regulation of biological quality regulation of anatomical structure morphogenesis regulation of cellular process regulation of cellular component organization protein-containing complex organization developmental process regulation of biological process regulation of developmental process biological regulation regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis anatomical structure development regulation of biological quality regulation of anatomical structure morphogenesis regulation of cellular process regulation of cellular component organization protein-containing complex organization regulation of cellular component biogenesis cellular component biogenesis cellular component organization regulation of protein-containing complex assembly cellular component assembly regulation of integrin activation protein-containing complex assembly cellular process cellular component organization or biogenesis integrin activation cell adhesion cell-cell adhesion	cell junction cellular anatomical entity anchoring junction focal adhesion cell-substrate junction intracellular anatomical structure actin filament bundle actin cytoskeleton actomyosin intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle stress fiber cell junction cellular anatomical entity anchoring junction focal adhesion cell-substrate junction intracellular anatomical structure actin filament bundle actin cytoskeleton actomyosin intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle stress fiber contractile actin filament bundle non-membrane-bounded organelle cytoplasm cytosol cell periphery membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen organelle lumen fibrillar center nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, E, F, I [auth D], A, B, E, F, I [auth D], J [auth C]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A, B, E, F, I [auth D], A, B, E, F, I [auth D], J [auth C]	IPR001589	Actinin-type actin-binding domain, conserved site	Conserved Site
A, B, E, F, I [auth D], A, B, E, F, I [auth D], J [auth C]	IPR017868	Filamin/ABP280 repeat-like	Repeat
A, B, E, F, I [auth D], A, B, E, F, I [auth D], J [auth C]	IPR036872	CH domain superfamily	Homologous Superfamily
A, B, E, F, I [auth D], A, B, E, F, I [auth D], J [auth C]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, E, F, I [auth D], A, B, E, F, I [auth D], J [auth C]	IPR001298	Filamin/ABP280 repeat	Repeat
A, B, E, F, I [auth D], A, B, E, F, I [auth D], J [auth C]	IPR001715	Calponin homology domain	Domain
A, B, E, F, I [auth D], A, B, E, F, I [auth D], J [auth C]	IPR044801	Filamin family	Family
C [auth G], D [auth H], G [auth K], H [auth L], K [auth J], C [auth G], D [auth H], G [auth K], H [auth L], K [auth J], L [auth I]	IPR001781	Zinc finger, LIM-type	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, E, F, I [auth D], A, B, E, F, I [auth D], J [auth C]	Pharos: P21333	periventricular nodular heterotopia cardiac valvular dysplasia, X-linked otopalatodigital syndrome type 2 FG syndrome Melnick-Needles syndrome terminal osseous dysplasia-pigmentary defects syndrome FG syndrome 2 frontometaphyseal dysplasia frontometaphyseal dysplasia 1 intestinal pseudoobstruction, neuronal, chronic idiopathic, X-linked otopalatodigital syndrome type 1 multiple epiphyseal dysplasia Oto-Palato-digital syndrome type 1 benign breast phyllodes tumor breast carcinoma periventricular nodular heterotopia cardiac valvular dysplasia, X-linked otopalatodigital syndrome type 2 FG syndrome Melnick-Needles syndrome terminal osseous dysplasia-pigmentary defects syndrome FG syndrome 2 frontometaphyseal dysplasia frontometaphyseal dysplasia 1 intestinal pseudoobstruction, neuronal, chronic idiopathic, X-linked otopalatodigital syndrome type 1 multiple epiphyseal dysplasia Oto-Palato-digital syndrome type 1 benign breast phyllodes tumor breast carcinoma osteochondrodysplasia heterotopia, periventricular, X-linked dominant congenital short bowel syndrome 1 epilepsy Marfan syndrome oligodendroglioma gastric carcinoma acute myeloid leukemia intellectual disability pancreatic ductal adenocarcinoma atypical teratoid rhabdoid tumor intestinal pseudo-obstruction lung carcinoma primitive neuroectodermal tumor malignant colon neoplasm spina bifida malignant glioma subependymal giant cell astrocytoma testicular germ cell tumor medulloblastoma FG syndrome 3 neuronal intestinal dysplasia glioblastoma otopalatodigital syndrome spectrum disorder arthrogryposis intestinal disease pancreatic intraductal papillary-mucinous neoplasm phyllodes tumor bowel dysfunction psoriasis spondyloepiphyseal dysplasia Ehlers-Danlos syndrome neuronal intestinal pseudoobstruction osteosarcoma hydrocephalus ovarian cancer astrocytic tumor intestinal obstruction pilocytic astrocytoma breast cancer malignant breast phyllodes tumor Schwartz-Jampel syndrome diabetes mellitus malignant ependymoma spondyloepiphyseal dysplasia tarda, X-linked malignant pancreatic neoplasm
C [auth G], D [auth H], G [auth K], H [auth L], K [auth J], C [auth G], D [auth H], G [auth K], H [auth L], K [auth J], L [auth I]	Pharos: Q8WUP2	adrenal cortex carcinoma gastric carcinoma large cell medulloblastoma medulloblastoma pilocytic astrocytoma atypical teratoid rhabdoid tumor glioblastoma malignant glioma osteosarcoma primitive neuroectodermal tumor Crohn disease interstitial lung disease malignant pancreatic neoplasm pancreatic ductal adenocarcinoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.