Annotations: 4P3F

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	RNA-binding signal recognition particle 68-like	8046407	4005065	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	TPR-like	8053751	3001345	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	TPR-like	8053751	3001345	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SRP68	e4p3fA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: SRP68	ECOD (1.6)
B	SRP68	e4p3fB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: SRP68	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.3450.40	Mainly Alpha	Orthogonal Bundle	Hyaluronidase domain-like	Signal recognition particle, SRP68 subunit, RNA-binding domain	CATH (4.3.0)
B	1.10.3450.40	Mainly Alpha	Orthogonal Bundle	Hyaluronidase domain-like	Signal recognition particle, SRP68 subunit, RNA-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF16969	RNA-binding signal recognition particle 68 (SRP68)	RNA-binding signal recognition particle 68	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Signal recognition particle subunit SRP68	endoplasmic reticulum signal peptide binding signal sequence binding binding peptide binding protein binding protein domain specific binding ribonucleoprotein complex binding protein-containing complex binding signal recognition particle binding RNA binding 7S RNA binding organic cyclic compound binding nucleic acid binding	response to stimulus response to chemical response to xenobiotic stimulus protein localization establishment of protein localization cellular localization establishment of protein localization to membrane protein targeting localization within membrane protein localization to membrane establishment of localization protein targeting to membrane localization SRP-dependent cotranslational protein targeting to membrane response to stimulus response to chemical response to xenobiotic stimulus protein localization establishment of protein localization cellular localization establishment of protein localization to membrane protein targeting localization within membrane protein localization to membrane establishment of localization protein targeting to membrane localization SRP-dependent cotranslational protein targeting to membrane establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle cotranslational protein targeting to membrane cellular process establishment of protein localization to endoplasmic reticulum protein localization to endoplasmic reticulum protein targeting to ER	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cytoplasm cytosol signal recognition particle protein-containing complex ribonucleoprotein complex signal recognition particle, endoplasmic reticulum targeting ribosome endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR038253	SRP68, N-terminal domain superfamily	Homologous Superfamily
A, B	IPR034652	Signal recognition particle subunit SRP68, RNA-binding domain	Domain
A, B	IPR026258	Signal recognition particle subunit SRP68	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9UHB9	Craniofacial Abnormalities ovarian cancer skin disease

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.