4P3D

MT1-MMP:Fab complex (Form II)

External Resource: Annotation


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad4p3da_ All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) automated matches (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
D [auth H]d4p3dh_ All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) automated matches (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
Bd4p3db1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
E [auth L]d4p3dl1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AV-set_8e4p3dA2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
AC1-set_1e4p3dA1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
D [auth H]V-set_8e4p3dH2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
D [auth H]C1-set_1e4p3dH1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
BC1-set_4e4p3dB2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
BV-sete4p3dB1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
E [auth L]C1-set_4e4p3dL2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
E [auth L]V-sete4p3dL1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
D [auth H]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
B2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
E [auth L]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
A,
D [auth H]		LEM-2/15 VH-CH1 Mus musculus (house mouse) IGHV5-9*04, IGHJ3*01, IGHG1*02 V-DOMAIN VH, C-DOMAIN CH1 IG FAB-GAMMA-1_KAPPA IMGT (202415-0)
B,
E [auth L]		LEM-2/15 L-KAPPA Mus musculus (house mouse) IGKV1-117*01, IGKJ2*01, IGKC*01, IGKC*02 V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA IG FAB-GAMMA-1_KAPPA IMGT (202415-0)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
A,
D [auth H]		Heavy ChainIGHV5 -matrix metalloproteinase-14SAbDab (2024-04-19)
B,
E [auth L]		Light ChainIGKV1 Kappamatrix metalloproteinase-14SAbDab (2024-04-19)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
B,
E [auth L]		PF07686Immunoglobulin V-set domain (V-set)Immunoglobulin V-set domainThis domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.Domain
B,
E [auth L]		PF07654Immunoglobulin C1-set domain (C1-set)Immunoglobulin C1-set domain- Domain
C,
F [auth M]		PF00413Matrixin (Peptidase_M10)MatrixinThe members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A,
D [auth H]		Heavy Chain Fab fragment of antibody LEM-2/15---
B,
E [auth L]		Light Chain Fab fragment of antibody LEM-2/15 - -
C,
F [auth M]		Matrix metalloproteinase-14

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
B,
E [auth L]		IPR003597Immunoglobulin C1-setDomain
B,
E [auth L]		IPR013783Immunoglobulin-like foldHomologous Superfamily
B,
E [auth L]		IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
B,
E [auth L]		IPR003599Immunoglobulin subtypeDomain
B,
E [auth L]		IPR013106Immunoglobulin V-set domainDomain
B,
E [auth L]		IPR007110Immunoglobulin-like domainDomain
B,
E [auth L]		IPR003006Immunoglobulin/major histocompatibility complex, conserved siteConserved Site
C,
F [auth M]		IPR021158Peptidase M10A, cysteine switch, zinc binding siteBinding Site
C,
F [auth M]		IPR021190Peptidase M10AFamily
C,
F [auth M]		IPR002477Peptidoglycan binding-likeDomain
C,
F [auth M]		IPR006026Peptidase, metallopeptidaseDomain
C,
F [auth M]		IPR033739Peptidase M10A, catalytic domainDomain
C,
F [auth M]		IPR018486Hemopexin, conserved siteConserved Site
C,
F [auth M]		IPR036375Hemopexin-like domain superfamilyHomologous Superfamily
C,
F [auth M]		IPR036365PGBD-like superfamilyHomologous Superfamily
C,
F [auth M]		IPR001818Peptidase M10, metallopeptidaseDomain
C,
F [auth M]		IPR021805Peptidase M10A, matrix metallopeptidase, C-terminalDomain
C,
F [auth M]		IPR024079Metallopeptidase, catalytic domain superfamilyHomologous Superfamily
C,
F [auth M]		IPR018487Hemopexin-like repeatsRepeat
C,
F [auth M]		IPR000585Hemopexin-like domainDomain
C,
F [auth M]		IPR036366PGBD superfamilyHomologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
C,
F [auth M]		Pharos:  P50281