4OVN

Voltage-gated Sodium Channel 1.5 (Nav1.5) C-terminal domain in complex with Calmodulin poised for activation

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4ovna_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth B]	d4ovnb_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth C]	d4ovnc_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G [auth D]	d4ovnd_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I [auth E]	d4ovne_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	EF-hand	8033438	3001983	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	EF-hand	8033438	3001983	SCOP2B (2022-06-29)
E [auth C]	SCOP2B Superfamily	EF-hand	8033438	3001983	SCOP2B (2022-06-29)
G [auth D]	SCOP2B Superfamily	EF-hand	8033438	3001983	SCOP2B (2022-06-29)
I [auth E]	SCOP2B Superfamily	EF-hand	8033438	3001983	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00036	e4ovnA2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
A	PF13499	e4ovnA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13499	ECOD (1.6)
C [auth B]	PF00036	e4ovnB2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
C [auth B]	PF13499	e4ovnB1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13499	ECOD (1.6)
E [auth C]	PF00036	e4ovnC2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
E [auth C]	PF13499	e4ovnC1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13499	ECOD (1.6)
G [auth D]	PF00036	e4ovnD2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
G [auth D]	PF13499	e4ovnD1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13499	ECOD (1.6)
I [auth E]	PF00036	e4ovnE2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
I [auth E]	PF13499	e4ovnE1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13499	ECOD (1.6)
B [auth F]	F_UNCLASSIFIED	e4ovnF1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth F]	PF00612	e4ovnF2	A: extended segments	X: Voltage gated calcium channel IQ domain (From Topology)	H: Voltage gated calcium channel IQ domain (From Topology)	T: Voltage gated calcium channel IQ domain	F: PF00612	ECOD (1.6)
D [auth G]	F_UNCLASSIFIED	e4ovnG1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth G]	PF00612	e4ovnG2	A: extended segments	X: Voltage gated calcium channel IQ domain (From Topology)	H: Voltage gated calcium channel IQ domain (From Topology)	T: Voltage gated calcium channel IQ domain	F: PF00612	ECOD (1.6)
F [auth H]	F_UNCLASSIFIED	e4ovnH1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
F [auth H]	PF00612	e4ovnH2	A: extended segments	X: Voltage gated calcium channel IQ domain (From Topology)	H: Voltage gated calcium channel IQ domain (From Topology)	T: Voltage gated calcium channel IQ domain	F: PF00612	ECOD (1.6)
H [auth I]	F_UNCLASSIFIED	e4ovnI1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
H [auth I]	PF00612	e4ovnI2	A: extended segments	X: Voltage gated calcium channel IQ domain (From Topology)	H: Voltage gated calcium channel IQ domain (From Topology)	T: Voltage gated calcium channel IQ domain	F: PF00612	ECOD (1.6)
J	F_UNCLASSIFIED	e4ovnJ1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
J	PF00612	e4ovnJ2	A: extended segments	X: Voltage gated calcium channel IQ domain (From Topology)	H: Voltage gated calcium channel IQ domain (From Topology)	T: Voltage gated calcium channel IQ domain	F: PF00612	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth F]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
B [auth F]	1.20.5.1190	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	iswi atpase	CATH (4.3.0)
D [auth G]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
D [auth G]	1.20.5.1190	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	iswi atpase	CATH (4.3.0)
F [auth H]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
F [auth H]	1.20.5.1190	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	iswi atpase	CATH (4.3.0)
H [auth I]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
H [auth I]	1.20.5.1190	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	iswi atpase	CATH (4.3.0)
J	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
J	1.20.5.1190	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	iswi atpase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B], E [auth C], G [auth D], I [auth E]	PF13499	EF-hand domain pair (EF-hand_7)	EF-hand domain pair	-	Domain
B [auth F], D [auth G], F [auth H], H [auth I], J	PF00520	Ion transport protein (Ion_trans)	Ion transport protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B], E [auth C], G [auth D], I [auth E]	Calmodulin	cytoskeletal protein binding titin binding protein binding binding enzyme regulator activity protein phosphatase activator activity enzyme activator activity phosphatase activator activity molecular function activator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity molecular function inhibitor activity channel regulator activity cytoskeletal protein binding titin binding protein binding binding enzyme regulator activity protein phosphatase activator activity enzyme activator activity phosphatase activator activity molecular function activator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity molecular function inhibitor activity channel regulator activity transporter inhibitor activity calcium channel inhibitor activity ion channel inhibitor activity ion channel regulator activity calcium channel regulator activity transporter regulator activity channel inhibitor activity cyclase regulator activity cyclase activator activity adenylate cyclase regulator activity adenylate cyclase activator activity protein serine/threonine kinase activator activity kinase activator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity cation binding ion binding calcium ion binding metal ion binding small molecule binding transmembrane transporter binding kinase binding enzyme binding protein kinase binding calcium-dependent protein binding	organelle localization by membrane tethering localization organelle localization cellular process membrane docking heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation organelle localization by membrane tethering localization organelle localization cellular process membrane docking heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process regulation of biological quality heart contraction blood circulation regulation of heart rate positive regulation of phosphoprotein phosphatase activity protein dephosphorylation regulation of cellular process regulation of phosphatase activity regulation of catalytic activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of phosphatase activity positive regulation of macromolecule metabolic process phosphorus metabolic process protein modification process positive regulation of phosphorus metabolic process positive regulation of dephosphorylation regulation of dephosphorylation cellular metabolic process dephosphorylation regulation of protein metabolic process regulation of cellular metabolic process primary metabolic process regulation of molecular function regulation of hydrolase activity macromolecule modification regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process regulation of phosphoprotein phosphatase activity positive regulation of molecular function positive regulation of protein modification process organic substance metabolic process protein metabolic process positive regulation of cellular process organonitrogen compound metabolic process regulation of protein dephosphorylation positive regulation of catalytic activity positive regulation of protein dephosphorylation regulation of macromolecule metabolic process positive regulation of hydrolase activity regulation of calcium ion transmembrane transporter activity regulation of calcium ion transport regulation of localization negative regulation of ion transmembrane transporter activity negative regulation of calcium ion transmembrane transporter activity intracellular calcium ion homeostasis negative regulation of biological process negative regulation of ryanodine-sensitive calcium-release channel activity negative regulation of transport calcium ion transport negative regulation of cation transmembrane transport monoatomic cation homeostasis monoatomic cation transport intracellular monoatomic ion homeostasis regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport inorganic ion transmembrane transport establishment of localization regulation of cation channel activity inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol regulation of transmembrane transport chemical homeostasis negative regulation of calcium ion transmembrane transport cellular localization inorganic ion homeostasis transport negative regulation of cation channel activity homeostatic process monoatomic ion transmembrane transport negative regulation of monoatomic ion transport regulation of transmembrane transporter activity calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion metal ion transport negative regulation of transmembrane transport regulation of transporter activity maintenance of location in cell regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport positive regulation of sequestering of calcium ion negative regulation of monoatomic ion transmembrane transport negative regulation of release of sequestered calcium ion into cytosol intracellular monoatomic cation homeostasis negative regulation of cellular process monoatomic ion homeostasis monoatomic ion transport intracellular chemical homeostasis regulation of metal ion transport regulation of sequestering of calcium ion regulation of monoatomic ion transmembrane transporter activity calcium ion transmembrane import into cytosol regulation of transport sequestering of calcium ion negative regulation of transporter activity negative regulation of molecular function negative regulation of calcium ion transport cellular homeostasis regulation of ryanodine-sensitive calcium-release channel activity regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport response to stimulus response to metal ion response to chemical response to calcium ion response to inorganic substance sarcoplasmic reticulum calcium ion transport release of sequestered calcium ion into cytosol by sarcoplasmic reticulum release of sequestered calcium ion into cytosol by endoplasmic reticulum regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum negative regulation of voltage-gated calcium channel activity regulation of voltage-gated calcium channel activity negative regulation of high voltage-gated calcium channel activity regulation of high voltage-gated calcium channel activity cellular component disassembly catabolic process macroautophagy protein-containing complex organization autophagy protein-containing complex disassembly cellular catabolic process cellular component organization autophagosome maturation autophagosome membrane docking cellular component organization or biogenesis process utilizing autophagic mechanism cellular response to stimulus response to interferon-beta response to organic substance response to cytokine cellular response to interferon-beta cellular response to chemical stimulus cellular response to cytokine stimulus cellular response to organic substance regulation of cytokinesis regulation of cell cycle process cytokinesis regulation of cell division cell division cell cycle regulation of cell cycle cell cycle process positive regulation of cyclic-nucleotide phosphodiesterase activity regulation of cyclic-nucleotide phosphodiesterase activity cardiac muscle contraction intracellular signal transduction cell communication intracellular signaling cassette signal transduction regulation of cardiac muscle contraction muscle contraction regulation of striated muscle contraction calcium-mediated signaling regulation of muscle contraction signaling regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion striated muscle contraction regulation of cardiac muscle contraction by calcium ion signaling muscle system process regulation of muscle system process mitochondrion-endoplasmic reticulum membrane tethering positive regulation of phosphorylation regulation of transferase activity positive regulation of protein serine/threonine kinase activity positive regulation of protein phosphorylation protein phosphorylation phosphorylation positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity regulation of protein phosphorylation positive regulation of protein kinase activity positive regulation of transferase activity regulation of protein kinase activity regulation of phosphorylation cell cycle G2/M phase transition mitotic cell cycle process G2/M transition of mitotic cell cycle cell cycle phase transition mitotic cell cycle mitotic cell cycle phase transition regulation of peptidyl-threonine phosphorylation negative regulation of phosphate metabolic process negative regulation of cellular metabolic process negative regulation of protein modification process peptidyl-amino acid modification peptidyl-threonine modification negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of protein phosphorylation negative regulation of peptidyl-threonine phosphorylation negative regulation of phosphorus metabolic process negative regulation of phosphorylation peptidyl-threonine phosphorylation positive regulation of peptidyl-threonine phosphorylation cell communication by electrical coupling involved in cardiac conduction cell communication by electrical coupling regulation of cell communication by electrical coupling involved in cardiac conduction cardiac conduction regulation of cell communication cell communication involved in cardiac conduction regulation of cell communication by electrical coupling export across plasma membrane negative regulation of calcium ion export across plasma membrane regulation of calcium ion export across plasma membrane calcium ion export across plasma membrane export from cell biological process involved in interspecies interaction between organisms response to type II interferon cellular response to type II interferon response to biotic stimulus response to stress innate immune response response to external biotic stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus immune system process defense response to other organism positive regulation of cation transmembrane transport positive regulation of calcium ion transport positive regulation of monoatomic ion transport positive regulation of monoatomic ion transmembrane transport positive regulation of cation channel activity positive regulation of calcium ion transmembrane transporter activity positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport positive regulation of release of sequestered calcium ion into cytosol positive regulation of ryanodine-sensitive calcium-release channel activity positive regulation of transport positive regulation of transporter activity positive regulation of ion transmembrane transporter activity developmental process head development animal organ development brain development nervous system development substantia nigra development multicellular organism development central nervous system development midbrain development anatomical structure development neural nucleus development system development positive regulation of cell communication cell surface receptor signaling pathway via STAT positive regulation of signal transduction positive regulation of receptor signaling pathway via STAT regulation of signal transduction positive regulation of receptor signaling pathway via JAK-STAT positive regulation of response to stimulus regulation of receptor signaling pathway via JAK-STAT regulation of signaling cell surface receptor signaling pathway regulation of response to stimulus regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT positive regulation of signaling regulation of intracellular signal transduction regulation of calcium-mediated signaling regulation of action potential regulation of cardiac muscle cell action potential action potential cardiac muscle cell action potential regulation of membrane potential G protein-coupled receptor signaling pathway protein autophosphorylation regulation of protein autophosphorylation positive regulation of protein autophosphorylation detection of stimulus detection of chemical stimulus detection of calcium ion	intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle cell projection intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle cell projection sperm midpiece cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection protein-containing complex transmembrane transporter complex membrane membrane protein complex cation channel complex transporter complex calcium channel complex monoatomic ion channel complex sarcomere contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex myelin sheath vesicle centrosome microtubule organizing center cell periphery plasma membrane catalytic complex nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen voltage-gated potassium channel complex plasma membrane protein complex potassium channel complex extracellular region polymeric cytoskeletal fiber spindle microtubule microtubule
B [auth F], D [auth G], F [auth H], H [auth I], J	Sodium channel protein type 5 subunit alpha	monoatomic cation transmembrane transporter activity voltage-gated sodium channel activity involved in cardiac muscle cell action potential voltage-gated sodium channel activity monoatomic ion channel activity sodium channel activity sodium ion transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity voltage-gated sodium channel activity involved in AV node cell action potential monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity monoatomic cation transmembrane transporter activity voltage-gated sodium channel activity involved in cardiac muscle cell action potential voltage-gated sodium channel activity monoatomic ion channel activity sodium channel activity sodium ion transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity voltage-gated sodium channel activity involved in AV node cell action potential monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity cytoskeletal protein binding ankyrin binding protein binding binding calcium channel activity voltage-gated calcium channel activity gated channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity calcium ion transmembrane transporter activity high voltage-gated calcium channel activity fibroblast growth factor binding growth factor binding calmodulin binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding nitric-oxide synthase binding voltage-gated sodium channel activity involved in bundle of His cell action potential protein domain specific binding voltage-gated sodium channel activity involved in SA node cell action potential voltage-gated sodium channel activity involved in Purkinje myocyte action potential scaffold protein binding transmembrane transporter binding kinase binding protein kinase binding	membrane depolarization during action potential membrane depolarization biological regulation membrane depolarization during cardiac muscle cell action potential action potential regulation of biological quality cardiac muscle cell action potential regulation of membrane potential heart process multicellular organismal process system process cardiac muscle cell action potential involved in contraction signaling atrial cardiac muscle cell to AV node cell signaling membrane depolarization during action potential membrane depolarization biological regulation membrane depolarization during cardiac muscle cell action potential action potential regulation of biological quality cardiac muscle cell action potential regulation of membrane potential heart process multicellular organismal process system process cardiac muscle cell action potential involved in contraction signaling atrial cardiac muscle cell to AV node cell signaling regulation of heart contraction regulation of system process cell-cell signaling involved in cardiac conduction cardiac muscle contraction striated muscle contraction cell communication circulatory system process actin filament-based process regulation of multicellular organismal process atrial cardiac muscle cell to AV node cell communication cell communication involved in cardiac conduction blood circulation cardiac muscle cell contraction regulation of biological process atrial cardiac muscle cell action potential cell-cell signaling actin filament-based movement muscle contraction muscle system process regulation of blood circulation membrane depolarization during atrial cardiac muscle cell action potential cardiac conduction cellular process actin-mediated cell contraction heart contraction regulation of heart rate developmental process anatomical structure development brainstem development AV node cell to bundle of His cell communication regulation of cellular process regulation of membrane depolarization regulation of ventricular cardiac muscle cell membrane depolarization bundle of His cell to Purkinje myocyte signaling bundle of His cell to Purkinje myocyte communication bundle of His cell action potential regulation of atrial cardiac muscle cell membrane depolarization cardiac muscle cell membrane repolarization membrane repolarization regulation of membrane repolarization ventricular cardiac muscle cell membrane repolarization regulation of cardiac muscle cell membrane repolarization regulation of ventricular cardiac muscle cell membrane repolarization AV node cell action potential AV node cell to bundle of His cell signaling head development animal organ development brain development nervous system development multicellular organism development cerebellum development central nervous system development metencephalon development hindbrain development system development cellular response to stimulus cellular response to inorganic substance cellular response to metal ion response to stimulus response to inorganic substance cellular response to chemical stimulus response to metal ion response to chemical cellular response to calcium ion response to calcium ion Purkinje myocyte to ventricular cardiac muscle cell communication membrane depolarization during Purkinje myocyte cell action potential Purkinje myocyte action potential Purkinje myocyte to ventricular cardiac muscle cell signaling localization transport monoatomic ion transport monoatomic cation transport establishment of localization sodium ion transport metal ion transport regulation of muscle adaptation regulation of muscle system process response to muscle inactivity response to stimulus involved in regulation of muscle adaptation muscle adaptation response to denervation involved in regulation of muscle adaptation regulation of response to stimulus response to muscle inactivity involved in regulation of muscle adaptation response to inactivity regulation of heart rate by cardiac conduction ventricular cardiac muscle cell action potential regulation of actin filament-based process regulation of cardiac muscle contraction regulation of striated muscle contraction regulation of actin filament-based movement regulation of muscle contraction regulation of cardiac muscle cell contraction membrane depolarization during AV node cell action potential anatomical structure morphogenesis odontogenesis of dentin-containing tooth odontogenesis animal organ morphogenesis SA node cell to atrial cardiac muscle cell signaling SA node cell to atrial cardiac muscle cell communication SA node cell action potential membrane depolarization during SA node cell action potential cell population proliferation positive regulation of cell population proliferation positive regulation of epithelial cell proliferation positive regulation of biological process regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation positive regulation of cellular process monoatomic ion transmembrane transport sodium ion transmembrane transport inorganic ion transmembrane transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport import into cell calcium ion transmembrane import into cytosol import across plasma membrane inorganic cation import across plasma membrane calcium ion transport calcium ion import across plasma membrane inorganic ion import across plasma membrane calcium ion import calcium ion import into cytosol calcium ion transmembrane transport heart development cardiac chamber development cardiac ventricle development circulatory system development regulation of action potential positive regulation of action potential regulation of localization regulation of monoatomic ion transmembrane transport regulation of sodium ion transport regulation of sodium ion transmembrane transport regulation of metal ion transport regulation of transport regulation of monoatomic ion transport regulation of transmembrane transport regulation of monoatomic cation transmembrane transport forebrain development telencephalon development atrial cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane repolarization cardiac conduction system development cardiac muscle tissue development tissue development striated muscle tissue development muscle tissue development positive regulation of sodium ion transport positive regulation of transport positive regulation of monoatomic ion transport membrane depolarization during bundle of His cell action potential	cell periphery sarcolemma plasma membrane membrane T-tubule cellular anatomical entity intracellular anatomical structure Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cell periphery sarcolemma plasma membrane membrane T-tubule cellular anatomical entity intracellular anatomical structure Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle perinuclear region of cytoplasm cell-cell junction intercalated disc anchoring junction cell junction cell-cell contact zone membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen organelle lumen nuclear lumen cell surface membrane microdomain membrane raft plasma membrane raft plasma membrane region caveola nucleoplasm protein-containing complex sodium channel complex voltage-gated sodium channel complex plasma membrane protein complex membrane protein complex cation channel complex transporter complex transmembrane transporter complex monoatomic ion channel complex lateral plasma membrane voltage-gated calcium channel complex calcium channel complex endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B], E [auth C], G [auth D], I [auth E]	IPR002048	EF-hand domain	Domain
A, C [auth B], E [auth C], G [auth D], I [auth E]	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A, C [auth B], E [auth C], G [auth D], I [auth E]	IPR011992	EF-hand domain pair	Homologous Superfamily
B [auth F], D [auth G], F [auth H], H [auth I], J	IPR010526	Sodium ion transport-associated domain	Domain
B [auth F], D [auth G], F [auth H], H [auth I], J	IPR043203	Voltage-gated cation channel calcium and sodium	Family
B [auth F], D [auth G], F [auth H], H [auth I], J	IPR008053	Voltage gated sodium channel, alpha-5 subunit	Family
B [auth F], D [auth G], F [auth H], H [auth I], J	IPR024583	Voltage-gated Na+ ion channel, cytoplasmic domain	Domain
B [auth F], D [auth G], F [auth H], H [auth I], J	IPR001696	Voltage gated sodium channel, alpha subunit	Family
B [auth F], D [auth G], F [auth H], H [auth I], J	IPR005821	Ion transport domain	Domain
B [auth F], D [auth G], F [auth H], H [auth I], J	IPR044564	Voltage-gated sodium channel alpha subunit, inactivation gate	Domain
B [auth F], D [auth G], F [auth H], H [auth I], J	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C [auth B], E [auth C], G [auth D], I [auth E]	Pharos: P0DP23	long QT syndrome catecholaminergic polymorphic ventricular tachycardia Alzheimer disease long QT syndrome 14 cocaine abuse Weight Gain cannabis dependence cocaine dependence phencyclidine abuse catecholaminergic polymorphic ventricular tachycardia 4 rheumatoid arthritis subependymal giant cell astrocytoma glioblastoma large cell medulloblastoma lung adenocarcinoma long QT syndrome catecholaminergic polymorphic ventricular tachycardia Alzheimer disease long QT syndrome 14 cocaine abuse Weight Gain cannabis dependence cocaine dependence phencyclidine abuse catecholaminergic polymorphic ventricular tachycardia 4 rheumatoid arthritis subependymal giant cell astrocytoma glioblastoma large cell medulloblastoma lung adenocarcinoma malignant colon neoplasm malignant pancreatic neoplasm myopathy astrocytic tumor osteosarcoma pituitary cancer primitive neuroectodermal tumor Crohn disease schizophrenia familial long QT syndrome lung cancer malignant ependymoma nasopharyngeal carcinoma atypical teratoid rhabdoid tumor ovarian cancer Pick disease catecholaminergic polymorphic ventricular tachycardia 2 plasma cell myeloma psoriasis exocrine pancreatic carcinoma sinusitis ulcerative colitis hepatocellular carcinoma lymphoplasmacytic lymphoma malignant glioma medulloblastoma amyotrophic lateral sclerosis oligodendroglioma breast cancer pilocytic astrocytoma
B [auth F], D [auth G], F [auth H], H [auth I], J	Pharos: Q14524	atrial fibrillation Sudden infant death syndrome Brugada syndrome long QT syndrome familial atrial fibrillation long QT syndrome 3 dilated cardiomyopathy 1E progressive familial heart block, type 1A ventricular fibrillation, paroxysmal familial, type 1 atrial fibrillation, familial, 10 ventricular tachycardia dilated cardiomyopathy sick sinus syndrome torsades de pointes sick sinus syndrome 1 atrial fibrillation Sudden infant death syndrome Brugada syndrome long QT syndrome familial atrial fibrillation long QT syndrome 3 dilated cardiomyopathy 1E progressive familial heart block, type 1A ventricular fibrillation, paroxysmal familial, type 1 atrial fibrillation, familial, 10 ventricular tachycardia dilated cardiomyopathy sick sinus syndrome torsades de pointes sick sinus syndrome 1 arrhythmogenic right ventricular cardiomyopathy cardiomyopathy Brugada syndrome 1 psoriasis long QT syndrome 1 scabies epilepsy with generalized tonic-clonic seizures amyotrophic lateral sclerosis familial isolated dilated cardiomyopathy status epilepticus glossopharyngeal neuralgia hemorrhoid Pediculus humanus capitis infestation tinea pedis premature ejaculation trigeminal neuralgia Pthirus pubis infestation Charcot-Marie-Tooth disease epilepsy malaria neuralgia familial long QT syndrome atrial standstill tinea corporis bipolar disorder left ventricular noncompaction urethritis progressive familial heart block familial dilated cardiomyopathy familial sick sinus syndrome paroxysmal familial ventricular fibrillation atrial fibrillation, familial, 1 heart disease partial epilepsy atrial standstill 1 hypertrophic cardiomyopathy postherpetic neuralgia Lennox-Gastaut syndrome