4OUH

Crystal structure of the FP domain of Human PI31 Proteasome Inhibitor

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PI31 FP domain-like	8053436	3002186	SCOP2B (2022-06-29)
B	SCOP2 Family	PI31 FP domain-like	8046665	4005227	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	PI31 FP domain-like	8053436	3002186	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	PI31 FP domain-like	8053436	3002186	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	PI31 FP domain-like	8053436	3002186	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PI31_Prot_N	e4ouhA1	A: a+b two layers	X: Type III secretory system chaperone-like	H: FP (Fbxo7/PI31) dimerization domain (From Topology)	T: FP (Fbxo7/PI31) dimerization domain	F: PI31_Prot_N	ECOD (1.6)
B	PI31_Prot_N	e4ouhB1	A: a+b two layers	X: Type III secretory system chaperone-like	H: FP (Fbxo7/PI31) dimerization domain (From Topology)	T: FP (Fbxo7/PI31) dimerization domain	F: PI31_Prot_N	ECOD (1.6)
C	PI31_Prot_N	e4ouhC1	A: a+b two layers	X: Type III secretory system chaperone-like	H: FP (Fbxo7/PI31) dimerization domain (From Topology)	T: FP (Fbxo7/PI31) dimerization domain	F: PI31_Prot_N	ECOD (1.6)
D	PI31_Prot_N	e4ouhD1	A: a+b two layers	X: Type III secretory system chaperone-like	H: FP (Fbxo7/PI31) dimerization domain (From Topology)	T: FP (Fbxo7/PI31) dimerization domain	F: PI31_Prot_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.1000.30	Alpha Beta	3-Layer(aba) Sandwich	Protein Transport Mog1p	Chain A	CATH (4.3.0)
B	3.40.1000.30	Alpha Beta	3-Layer(aba) Sandwich	Protein Transport Mog1p	Chain A	CATH (4.3.0)
C	3.40.1000.30	Alpha Beta	3-Layer(aba) Sandwich	Protein Transport Mog1p	Chain A	CATH (4.3.0)
D	3.40.1000.30	Alpha Beta	3-Layer(aba) Sandwich	Protein Transport Mog1p	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF11566	PI31 proteasome regulator N-terminal (PI31_Prot_N)	PI31 proteasome regulator N-terminal	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Proteasome inhibitor PI31 subunit	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity protein heterodimerization activity protein-containing complex binding proteasome binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity protein heterodimerization activity protein-containing complex binding proteasome binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process negative regulation of proteolysis negative regulation of proteolysis involved in protein catabolic process negative regulation of biological process regulation of primary metabolic process negative regulation of protein catabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of catabolic process regulation of biological process regulation of protein metabolic process negative regulation of metabolic process biological regulation proteasomal protein catabolic process regulation of macromolecule metabolic process regulation of catabolic process negative regulation of proteasomal protein catabolic process regulation of proteasomal protein catabolic process regulation of metabolic process regulation of protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex proteasome core complex intracellular protein-containing complex membrane-bounded organelle membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex proteasome core complex intracellular protein-containing complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR013886	PI31 proteasome regulator, C-terminal	Domain
A, B, C, D	IPR021625	PI31 proteasome regulator, N-terminal	Domain
A, B, C, D	IPR045128	Proteasome inhibitor PI31-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q92530	astrocytic tumor lung cancer ovarian cancer dermatomyositis malignant ependymoma glioblastoma osteosarcoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.