4OTN
Crystal structure of the C-terminal regulatory domain of murine GCN2
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | F_UNCLASSIFIED | e4otnA1 | A: a+b two layers | X: Serine/threonine-protein kinase GCN2 C-terminal domain (From Topology) | H: Serine/threonine-protein kinase GCN2 C-terminal domain (From Topology) | T: Serine/threonine-protein kinase GCN2 C-terminal domain | F: F_UNCLASSIFIED | ECOD (1.6) |
B | F_UNCLASSIFIED | e4otnB1 | A: a+b two layers | X: Serine/threonine-protein kinase GCN2 C-terminal domain (From Topology) | H: Serine/threonine-protein kinase GCN2 C-terminal domain (From Topology) | T: Serine/threonine-protein kinase GCN2 C-terminal domain | F: F_UNCLASSIFIED | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF12745 | Anticodon binding domain of tRNAs (HGTP_anticodon2) | Anticodon binding domain of tRNAs | This is an HGTP_anticodon binding domain, found largely on Gcn2 proteins which bind tRNA to down regulate translation in certain stress situations. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR041715 | Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain | Domain | |
IPR000719 | Protein kinase domain | Domain | |
IPR006575 | RWD domain | Domain | |
IPR017441 | Protein kinase, ATP binding site | Binding Site | |
IPR045864 | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | Homologous Superfamily | |
IPR016135 | Ubiquitin-conjugating enzyme/RWD-like | Homologous Superfamily | |
IPR036621 | Anticodon-binding domain superfamily | Homologous Superfamily | |
IPR011009 | Protein kinase-like domain superfamily | Homologous Superfamily | |
IPR016255 | eIF-2-alpha kinase Gcn2 | Family | |
IPR024435 | Histidyl tRNA synthetase-related domain | Domain | |
IPR008271 | Serine/threonine-protein kinase, active site | Active Site |