4OJE

Crystal structure of a C-terminally truncated trimeric ectodomain of the C. elegans fusion protein EFF-1

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth H]	EFF-AFF_2nd	e4ojeH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: EFF-AFF_2nd	ECOD (1.6)
A [auth H]	EFF-AFF_1st	e4ojeH1	A: beta complex topology	X: Viral glycoprotein, central and dimerisation domains-like	H: Viral glycoprotein, central and dimerisation domains (From Topology)	T: Viral glycoprotein, central and dimerisation domains	F: EFF-AFF_1st	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth H]	2.60.98.60	Mainly Beta	Sandwich	Tick-borne Encephalitis virus Glycoprotein	domain 1	CATH (4.3.0)
A [auth H]	2.60.40.3980	Mainly Beta	Sandwich	Immunoglobulin-like	Cell-cell fusogen EFF/AFF, domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth H]	PF14884	Type I membrane glycoproteins cell-cell fusogen (EFF-AFF)	Type I membrane glycoproteins cell-cell fusogen	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth H]	EFF-1A	kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups fusogenic activity identical protein binding protein binding binding	developmental process anatomical structure morphogenesis multicellular organism development multicellular organismal process anatomical structure development post-embryonic animal morphogenesis post-embryonic development post-embryonic body morphogenesis body morphogenesis locomotion syncytium formation by plasma membrane fusion anatomical structure formation involved in morphogenesis cell-cell fusion cellular process developmental process anatomical structure morphogenesis multicellular organism development multicellular organismal process anatomical structure development post-embryonic animal morphogenesis post-embryonic development post-embryonic body morphogenesis body morphogenesis locomotion syncytium formation by plasma membrane fusion anatomical structure formation involved in morphogenesis cell-cell fusion cellular process syncytium formation embryonic body morphogenesis embryonic morphogenesis embryo development behavior egg-laying behavior reproductive process multicellular organismal reproductive process reproductive behavior tissue morphogenesis epithelium development morphogenesis of an epithelium tissue development vulval development animal organ development nematode larval development larval development male genitalia morphogenesis genitalia development reproductive system development male anatomical structure morphogenesis sensory organ development sex differentiation developmental process involved in reproduction male sex differentiation sensory organ morphogenesis reproductive structure development male genitalia development nematode male tail mating organ morphogenesis animal organ morphogenesis genitalia morphogenesis system development phosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process phosphorus metabolic process nematode male tail tip morphogenesis digestive system development tube development digestive tract development muscle structure development pharynx development chordate pharyngeal muscle development chordate pharynx development muscle organ development	cell periphery plasma membrane membrane cellular anatomical entity intracellular anatomical structure cytoplasm cell-cell junction anchoring junction cell junction cell-cell contact zone protein-containing complex plasma membrane protein complex membrane protein complex EFF-1 complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth H]	IPR029213	Cell-cell fusogen EFF/AFF	Family
A [auth H]	IPR043076	Cell-cell fusogen EFF/AFF, domain 3	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.