Annotations: 4OIC

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2 Family	PP2C-like	8091297	4007727	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	PP2C-like	8091298	3000909	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Polyketide_cyc	e4oicA1	A: a+b two layers	X: TBP-like	H: Bet v1-like (From Topology)	T: Bet v1-like	F: Polyketide_cyc	ECOD (1.6)
B	PP2C	e4oicB1	A: a+b four layers	X: Ntn/PP2C	H: Protein serine/threonine phosphatase 2C, catalytic domain (From Topology)	T: Protein serine/threonine phosphatase 2C, catalytic domain	F: PP2C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.530.20	Alpha Beta	2-Layer Sandwich	Alpha-D-Glucose-1,6-Bisphosphate	Chain A, domain 4	CATH (4.3.0)
B	3.60.40.10	Alpha Beta	4-Layer Sandwich	Phosphatase 2c	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF10604	Polyketide cyclase / dehydrase and lipid transport (Polyketide_cyc2)	Polyketide cyclase / dehydrase and lipid transport	-	Family
B	PF00481	Protein phosphatase 2C (PP2C)	Protein phosphatase 2C	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Bet v I allergen-like	enzyme regulator activity phosphatase inhibitor activity molecular function inhibitor activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity protein phosphatase inhibitor activity enzyme inhibitor activity molecular transducer activity signaling receptor activity identical protein binding protein binding binding protein homodimerization activity enzyme regulator activity phosphatase inhibitor activity molecular function inhibitor activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity protein phosphatase inhibitor activity enzyme inhibitor activity molecular transducer activity signaling receptor activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity organic acid binding alcohol binding isoprenoid binding hormone binding ion binding abscisic acid binding anion binding lipid binding carboxylic acid binding monocarboxylic acid binding small molecule binding	response to acid chemical response to stimulus response to stress response to chemical response to oxygen-containing compound response to abiotic stimulus response to water response to water deprivation response to inorganic substance response to cold response to temperature stimulus cellular response to stimulus response to organic substance regulation of cellular process response to acid chemical response to stimulus response to stress response to chemical response to oxygen-containing compound response to abiotic stimulus response to water response to water deprivation response to inorganic substance response to cold response to temperature stimulus cellular response to stimulus response to organic substance regulation of cellular process response to lipid abscisic acid-activated signaling pathway signaling hormone-mediated signaling pathway cell communication cellular response to endogenous stimulus response to hormone cellular response to organic substance signal transduction cellular response to hormone stimulus cellular response to abscisic acid stimulus regulation of biological process response to abscisic acid response to alcohol response to endogenous stimulus biological regulation cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol cellular response to lipid cellular process developmental process multicellular organism development multicellular organismal process anatomical structure development post-embryonic development seed germination seedling development protein dephosphorylation regulation of phosphatase activity regulation of catalytic activity negative regulation of protein serine/threonine phosphatase activity negative regulation of biological process negative regulation of catalytic activity negative regulation of cellular metabolic process regulation of primary metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of dephosphorylation phosphorus metabolic process protein modification process negative regulation of protein metabolic process regulation of dephosphorylation cellular metabolic process negative regulation of metabolic process dephosphorylation regulation of protein metabolic process regulation of cellular metabolic process primary metabolic process regulation of molecular function regulation of hydrolase activity macromolecule modification regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process negative regulation of hydrolase activity negative regulation of phosphoprotein phosphatase activity negative regulation of protein dephosphorylation regulation of protein modification process negative regulation of phosphate metabolic process regulation of phosphoprotein phosphatase activity organic substance metabolic process negative regulation of phosphatase activity negative regulation of cellular process protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process regulation of protein dephosphorylation negative regulation of molecular function regulation of macromolecule metabolic process negative regulation of phosphorus metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
B	Probable protein phosphatase 2C 6	phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds myosin phosphatase activity phosphatase activity hydrolase activity catalytic activity cation binding ion binding binding metal ion binding small molecule binding	cellular response to stimulus response to organic substance regulation of cellular process response to stimulus response to lipid abscisic acid-activated signaling pathway signaling hormone-mediated signaling pathway cell communication cellular response to endogenous stimulus response to hormone cellular response to organic substance signal transduction cellular response to hormone stimulus cellular response to stimulus response to organic substance regulation of cellular process response to stimulus response to lipid abscisic acid-activated signaling pathway signaling hormone-mediated signaling pathway cell communication cellular response to endogenous stimulus response to hormone cellular response to organic substance signal transduction cellular response to hormone stimulus cellular response to abscisic acid stimulus regulation of biological process response to abscisic acid response to alcohol response to endogenous stimulus biological regulation response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol response to chemical cellular response to lipid cellular process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR023393	START-like domain superfamily	Homologous Superfamily
A	IPR019587	Polyketide cyclase/dehydrase	Family
B	IPR036457	PPM-type phosphatase-like domain superfamily	Homologous Superfamily
B	IPR015655	Protein phosphatase 2C	Family
B	IPR000222	PPM-type phosphatase, divalent cation binding	Binding Site
B	IPR001932	PPM-type phosphatase-like domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.