4OFY

Crystal Structure of the Complex of SYG-1 D1-D2 and SYG-2 D1-D4

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07679	e4ofyA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07679	ECOD (1.6)
A	PF08205	e4ofyA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF08205	ECOD (1.6)
B	PF07679	e4ofyB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07679	ECOD (1.6)
B	PF08205	e4ofyB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF08205	ECOD (1.6)
C	PF07679	e4ofyC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07679	ECOD (1.6)
C	PF08205	e4ofyC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF08205	ECOD (1.6)
D	PF07686	e4ofyD4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
D	PF08205	e4ofyD3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF08205	ECOD (1.6)
D	PF22705	e4ofyD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF22705	ECOD (1.6)
E	PF08205	e4ofyE2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF08205	ECOD (1.6)
E	PF08205,PF13927	e4ofyE3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF08205,PF13927	ECOD (1.6)
E	PF13927	e4ofyE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF13927	ECOD (1.6)
F	PF07686	e4ofyF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
F	PF08205	e4ofyF4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF08205	ECOD (1.6)
F	PF13927	e4ofyF2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF13927	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
F	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF07679	Immunoglobulin I-set domain (I-set)	Immunoglobulin I-set domain	-	Domain
A, B, C	PF08205	CD80-like C2-set immunoglobulin domain (C2-set_2)	CD80-like C2-set immunoglobulin domain	These domains belong to the immunoglobulin superfamily.	Domain
D, E, F	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain
D, E, F	PF13927	Immunoglobulin domain (Ig_3)	Immunoglobulin domain	This family contains immunoglobulin-like domains.	Domain
D, E, F	PF08205	CD80-like C2-set immunoglobulin domain (C2-set_2)	CD80-like C2-set immunoglobulin domain	These domains belong to the immunoglobulin superfamily.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Protein SYG-1, isoform b	protein-containing complex binding binding cell adhesion molecule binding protein binding	developmental process anatomical structure morphogenesis multicellular organismal process multicellular organism development morphogenesis of a branching structure anatomical structure development branching morphogenesis of a nerve nervous system development system development cell adhesion cell-cell adhesion cellular process neuron recognition cellular developmental process developmental process anatomical structure morphogenesis multicellular organismal process multicellular organism development morphogenesis of a branching structure anatomical structure development branching morphogenesis of a nerve nervous system development system development cell adhesion cell-cell adhesion cellular process neuron recognition cellular developmental process cell development synaptic target recognition generation of neurons neurogenesis neuron differentiation cell differentiation neuron development cell recognition regulation of biological process signaling biological regulation cell-cell signaling cell communication cellular component organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly synapse organization cellular component organization or biogenesis synapse assembly actin cytoskeleton organization actin filament organization organelle organization actin filament bundle organization actin filament bundle assembly actin filament-based process supramolecular fiber organization cytoskeleton organization axonogenesis developmental growth cell projection organization plasma membrane bounded cell projection morphogenesis neuron projection development cell growth cell morphogenesis cell projection morphogenesis neuron projection morphogenesis collateral sprouting plasma membrane bounded cell projection organization developmental cell growth growth axon development cell morphogenesis involved in neuron differentiation developmental growth involved in morphogenesis	cell-cell junction anchoring junction cell junction cellular anatomical entity cell periphery membrane plasma membrane synapse plasma membrane region synaptic membrane axon cell projection neuron projection plasma membrane bounded cell projection cell-cell junction anchoring junction cell junction cellular anatomical entity cell periphery membrane plasma membrane synapse plasma membrane region synaptic membrane axon cell projection neuron projection plasma membrane bounded cell projection protein-containing complex protein complex involved in cell adhesion
D, E, F	Protein SYG-2	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity cell adhesion molecule binding	cell adhesion cell-cell adhesion cellular process protein localization localization cellular localization protein localization to synapse cellular macromolecule localization macromolecule localization protein localization to cell junction developmental process neuron recognition multicellular organismal process cellular developmental process cell adhesion cell-cell adhesion cellular process protein localization localization cellular localization protein localization to synapse cellular macromolecule localization macromolecule localization protein localization to cell junction developmental process neuron recognition multicellular organismal process cellular developmental process cell development nervous system development synaptic target recognition generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation neuron development anatomical structure development cell recognition system development regulation of biological process signaling biological regulation cell-cell signaling cell communication cellular component organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly synapse organization cellular component organization or biogenesis synapse assembly axonogenesis developmental growth cell projection organization plasma membrane bounded cell projection morphogenesis neuron projection development cell growth cell morphogenesis cell projection morphogenesis neuron projection morphogenesis collateral sprouting plasma membrane bounded cell projection organization developmental cell growth growth axon development cell morphogenesis involved in neuron differentiation developmental growth involved in morphogenesis anatomical structure morphogenesis	cell-cell junction anchoring junction cell junction cellular anatomical entity cell periphery membrane plasma membrane synapse plasma membrane region synaptic membrane protein-containing complex protein complex involved in cell adhesion

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B, C	IPR003599	Immunoglobulin subtype	Domain
A, B, C	IPR003598	Immunoglobulin subtype 2	Domain
A, B, C	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C	IPR013162	CD80-like, immunoglobulin C2-set	Domain
A, B, C	IPR007110	Immunoglobulin-like domain	Domain
A, B, C	IPR013098	Immunoglobulin I-set	Domain
D, E, F	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
D, E, F	IPR003599	Immunoglobulin subtype	Domain
D, E, F	IPR003598	Immunoglobulin subtype 2	Domain
D, E, F	IPR003961	Fibronectin type III	Domain
D, E, F	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
D, E, F	IPR013106	Immunoglobulin V-set domain	Domain
D, E, F	IPR013162	CD80-like, immunoglobulin C2-set	Domain
D, E, F	IPR007110	Immunoglobulin-like domain	Domain
D, E, F	IPR013098	Immunoglobulin I-set	Domain
D, E, F	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.