Annotations: 4OF8

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08205	e4of8A2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF08205	ECOD (1.6)
A	PF13927	e4of8A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF13927	ECOD (1.6)
B	PF08205	e4of8B2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF08205	ECOD (1.6)
B	PF13927	e4of8B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF13927	ECOD (1.6)
C	PF08205	e4of8C2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF08205	ECOD (1.6)
C	PF13927	e4of8C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF13927	ECOD (1.6)
D	PF08205	e4of8D2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF08205	ECOD (1.6)
D	PF13927	e4of8D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF13927	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF07679	Immunoglobulin I-set domain (I-set)	Immunoglobulin I-set domain	-	Domain
A, B, C, D	PF08205	CD80-like C2-set immunoglobulin domain (C2-set_2)	CD80-like C2-set immunoglobulin domain	These domains belong to the immunoglobulin superfamily.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Irregular chiasm C-roughest protein	protein binding binding PDZ domain binding protein domain specific binding cell adhesion molecule binding identical protein binding	cell adhesion cell-cell adhesion cellular process cell-cell adhesion via plasma-membrane adhesion molecules developmental process regulation of muscle tissue development regulation of biological process regulation of developmental process biological regulation animal organ development regulation of striated muscle tissue development tissue development striated muscle tissue development muscle structure development cell adhesion cell-cell adhesion cellular process cell-cell adhesion via plasma-membrane adhesion molecules developmental process regulation of muscle tissue development regulation of biological process regulation of developmental process biological regulation animal organ development regulation of striated muscle tissue development tissue development striated muscle tissue development muscle structure development regulation of muscle organ development anatomical structure development muscle tissue development muscle organ development multicellular organismal process sensory organ development eye development visual system development eye morphogenesis multicellular organism development anatomical structure morphogenesis compound eye development compound eye morphogenesis sensory organ morphogenesis animal organ morphogenesis sensory system development system development chaeta morphogenesis chaeta development cellular developmental process photoreceptor cell differentiation neurogenesis neuron differentiation cell differentiation eye photoreceptor cell differentiation nervous system development generation of neurons compound eye photoreceptor cell differentiation myoblast fusion cell-cell fusion muscle cell differentiation myotube differentiation syncytium formation by plasma membrane fusion anatomical structure formation involved in morphogenesis syncytium formation striated muscle cell differentiation homophilic cell adhesion via plasma membrane adhesion molecules compound eye retinal cell programmed cell death cell development cell death programmed cell death involved in cell development retinal cell programmed cell death programmed cell death regulation of syncytium formation by plasma membrane fusion regulation of cellular component organization regulation of cellular process cellular component organization cellular component organization or biogenesis regulation of myoblast fusion	cell-cell junction anchoring junction cell junction cellular anatomical entity cell periphery apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane adherens junction protein-containing complex protein complex involved in cell adhesion

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR003599	Immunoglobulin subtype	Domain
A, B, C, D	IPR003598	Immunoglobulin subtype 2	Domain
A, B, C, D	IPR013098	Immunoglobulin I-set	Domain
A, B, C, D	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C, D	IPR013162	CD80-like, immunoglobulin C2-set	Domain
A, B, C, D	IPR007110	Immunoglobulin-like domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.