4O9U

Mechanism of transhydrogenase coupling proton translocation and hydride transfer

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	DHS-like NAD/FAD-binding domain	8076772	3001728	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	DHS-like NAD/FAD-binding domain	8076772	3001728	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	D-2-hydroxyacid dehydrogenase-like	8085303	3000044	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	D-2-hydroxyacid dehydrogenase-like	8085303	3000044	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PNTB_4TM	e4o9uA1	A: alpha bundles	X: Transhydrogeanse domain II (From Topology)	H: Transhydrogeanse domain II (From Topology)	T: Transhydrogeanse domain II	F: PNTB_4TM	ECOD (1.6)
C	PNTB_4TM	e4o9uC1	A: alpha bundles	X: Transhydrogeanse domain II (From Topology)	H: Transhydrogeanse domain II (From Topology)	T: Transhydrogeanse domain II	F: PNTB_4TM	ECOD (1.6)
B	PNTB_N	e4o9uB1	A: alpha bundles	X: Transhydrogeanse domain II (From Topology)	H: Transhydrogeanse domain II (From Topology)	T: Transhydrogeanse domain II	F: PNTB_N	ECOD (1.6)
B	PNTB_C	e4o9uB2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: DHS-like NAD/FAD-binding domain	F: PNTB_C	ECOD (1.6)
D	PNTB_N	e4o9uD1	A: alpha bundles	X: Transhydrogeanse domain II (From Topology)	H: Transhydrogeanse domain II (From Topology)	T: Transhydrogeanse domain II	F: PNTB_N	ECOD (1.6)
D	PNTB_C	e4o9uD2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: DHS-like NAD/FAD-binding domain	F: PNTB_C	ECOD (1.6)
E	AlaDh_PNT_C	e4o9uE2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: AlaDh_PNT_C	ECOD (1.6)
E	AlaDh_PNT_N	e4o9uE1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Formate/glycerate dehydrogenase catalytic domain-like	F: AlaDh_PNT_N	ECOD (1.6)
F	AlaDh_PNT_C	e4o9uF1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: AlaDh_PNT_C	ECOD (1.6)
F	AlaDh_PNT_N	e4o9uF2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Formate/glycerate dehydrogenase catalytic domain-like	F: AlaDh_PNT_N	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF12769	4TM region of pyridine nucleotide transhydrogenase, mitoch (PNTB_4TM)	4TM region of pyridine nucleotide transhydrogenase, mitoch	-	Family
B, D	PF02233	NAD(P) transhydrogenase beta subunit (PNTB)	NAD(P) transhydrogenase beta subunit	-	Family
E, F	PF05222	Alanine dehydrogenase/PNT, N-terminal domain (AlaDh_PNT_N)	Alanine dehydrogenase/PNT, N-terminal domain	This family now also contains the lysine 2-oxoglutarate reductases.	Domain
E, F	PF01262	Alanine dehydrogenase/PNT, C-terminal domain (AlaDh_PNT_C)	Alanine dehydrogenase/PNT, C-terminal domain	This family now also contains the lysine 2-oxoglutarate reductases.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	NAD(P) transhydrogenase subunit alpha 2	oxidoreductase activity catalytic activity	-	cell periphery plasma membrane membrane cellular anatomical entity
B, D	NAD(P) transhydrogenase subunit beta	binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding NADP binding small molecule binding oxidoreductase activity NAD(P)+ transhydrogenase (AB-specific) activity oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor NAD(P)+ transhydrogenase activity oxidoreductase activity, acting on NAD(P)H binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding NADP binding small molecule binding oxidoreductase activity NAD(P)+ transhydrogenase (AB-specific) activity oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor NAD(P)+ transhydrogenase activity oxidoreductase activity, acting on NAD(P)H catalytic activity	-	cell periphery plasma membrane membrane cellular anatomical entity
E, F	NAD/NADP transhydrogenase alpha subunit 1	oxidoreductase activity catalytic activity binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR024605	NAD(P) transhydrogenase, alpha subunit, C-terminal	Domain
B, D	IPR034300	NADP transhydrogenase beta-like domain	Domain
B, D	IPR029035	DHS-like NAD/FAD-binding domain superfamily	Homologous Superfamily
B, D	IPR012136	NADP transhydrogenase, beta subunit	Family
E, F	IPR007886	Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal	Domain
E, F	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
E, F	IPR008143	Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2	Conserved Site
E, F	IPR007698	Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D	OPM	Transmembrane	Alpha-helical polytopic	Proton-translocating transhydrogenase	NAD(P) transhydrogenase

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Transhydrogenases	Nicotinamide nucleotide transhydrogenase (TH) proton channel domain, pH 8.5

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.