Annotations: 4O9D

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	ANAPC4_WD40_9	e4o9dB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: ANAPC4_WD40_9	ECOD (1.6)
B [auth A]	ANAPC4_WD40_9	e4o9dA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: ANAPC4_WD40_9	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
B [auth A]	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	Rik1-associated factor 1	cytoskeletal protein binding microtubule plus-end binding microtubule binding protein binding binding tubulin binding protein-containing complex binding dynein complex binding	establishment of organelle localization meiotic chromosome segregation cellular localization sexual reproduction reproductive process meiotic cell cycle process cellular component organization localization telomere localization meiosis I chromosome localization organelle localization establishment of localization in cell meiotic nuclear division establishment of organelle localization meiotic chromosome segregation cellular localization sexual reproduction reproductive process meiotic cell cycle process cellular component organization localization telomere localization meiosis I chromosome localization organelle localization establishment of localization in cell meiotic nuclear division cell cycle cellular component organization or biogenesis chromosome segregation cell cycle process meiotic cell cycle organelle fission meiotic telomere clustering chromosome organization establishment of localization chromosome organization involved in meiotic cell cycle nuclear division organelle organization chromosome localization to nuclear envelope involved in homologous chromosome segregation meiosis I cell cycle process nuclear chromosome segregation cellular process homologous chromosome segregation establishment of chromosome localization vesicle cytoskeletal trafficking vesicle localization organelle transport along microtubule transport establishment of vesicle localization intracellular transport vesicle transport along microtubule microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process nucleus localization nuclear migration regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process protein-DNA complex organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process pericentric heterochromatin formation protein-DNA complex assembly CENP-A containing chromatin assembly cellular component biogenesis cellular component assembly protein-containing complex assembly centromere complex assembly chromatin remodeling at centromere microtubule organizing center organization microtubule cytoskeleton organization cytoskeleton organization spindle localization establishment or maintenance of cell polarity mitotic cell cycle establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation microtubule cytoskeleton organization involved in mitosis establishment of cell polarity mitotic cell cycle process establishment of mitotic spindle orientation subtelomeric heterochromatin formation telomere organization regulatory ncRNA-mediated gene silencing regulatory ncRNA-mediated heterochromatin formation	membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol protein-containing complex protein-DNA complex membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol protein-containing complex protein-DNA complex mating-type region heterochromatin chromatin chromosome heterochromatin intracellular non-membrane-bounded organelle non-membrane-bounded organelle ubiquitin ligase complex membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen CLRC complex cullin-RING ubiquitin ligase complex nucleoplasm methyltransferase complex histone methyltransferase complex catalytic complex Cul4-RING E3 ubiquitin ligase complex nuclear ubiquitin ligase complex organelle lumen intracellular protein-containing complex nuclear lumen pericentric heterochromatin chromosomal region chromosome, centromeric region kinetochore condensed chromosome, centromeric region supramolecular complex condensed chromosome polymeric cytoskeletal fiber cytoplasmic microtubule cytoskeleton supramolecular fiber microtubule supramolecular polymer microtubule cytoskeleton microtubule associated complex chromosome, telomeric region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR019775	WD40 repeat, conserved site	Conserved Site
A [auth B], B [auth A]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR001680	WD40 repeat	Repeat
A [auth B], B [auth A]	IPR020472	G-protein beta WD-40 repeat	Repeat

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.