4O6M

Structure of AF2299, a CDP-alcohol phosphotransferase (CMP-bound)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	CDP-alcohol phosphatidyltransferase N-terminal cytosolic domain-like	8048507	4006126	SCOP2 (2022-06-29)
A	SCOP2 Family	DIPPS domain-like	8090038	4007695	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Nucleotide-diphospho-sugar transferases	8090044	3000077	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DIPPS domain-like	8090041	3002413	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	DIPPS domain-like	8090041	3002413	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Nucleotide-diphospho-sugar transferases	8090044	3000077	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CDP-OH_P_transf	e4o6mA2	A: alpha bundles	X: CDP-alcohol phosphotransferase helical bundle domain (From Topology)	H: CDP-alcohol phosphotransferase helical bundle domain (From Topology)	T: CDP-alcohol phosphotransferase helical bundle domain	F: CDP-OH_P_transf	ECOD (1.6)
A	EUF08622	e4o6mA1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: EUF08622	ECOD (1.6)
B	CDP-OH_P_transf	e4o6mB1	A: alpha bundles	X: CDP-alcohol phosphotransferase helical bundle domain (From Topology)	H: CDP-alcohol phosphotransferase helical bundle domain (From Topology)	T: CDP-alcohol phosphotransferase helical bundle domain	F: CDP-OH_P_transf	ECOD (1.6)
B	EUF08622	e4o6mB2	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: EUF08622	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.550.30	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
A	1.20.120.1760	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	CDP-alcohol phosphotransferase transmembrane (TM) domain	CATH (4.3.0)
B	3.90.550.30	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
B	1.20.120.1760	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	CDP-alcohol phosphotransferase transmembrane (TM) domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21682	CDP-alcohol phosphatidyltransferase AF_2299-like, N-terminal (AF_2299-like_N)	CDP-alcohol phosphatidyltransferase AF_2299-like, N-terminal	This domain is found at the N-terminal end of CDP-alcohol phosphatidyltransferase family protein from Archaeoglobus fulgidus (AF_2299) and similar archaeal proteins. AF_2299 is a member of a family of membrane-embedded enzymes known as CDP-alcohol ph ...	This domain is found at the N-terminal end of CDP-alcohol phosphatidyltransferase family protein from Archaeoglobus fulgidus (AF_2299) and similar archaeal proteins. AF_2299 is a member of a family of membrane-embedded enzymes known as CDP-alcohol phosphotransferases (CDP-APs) involved in the formation of polar phospholipids. This integral membrane phosphotransferase is organised into two distinct domains. This entry represents the N-terminal cytoplasmic domain, which has structural similarity to the cytidyltransferases [1-3].	Domain
A, B	PF01066	CDP-alcohol phosphatidyltransferase (CDP-OH_P_transf)	CDP-alcohol phosphatidyltransferase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	AF2299, a CDP-alcohol phosphotransferase	transferase activity catalytic activity phosphotransferase activity, for other substituted phosphate groups transferase activity, transferring phosphorus-containing groups binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding cation binding ion binding metal ion binding	cellular metabolic process lipid biosynthetic process primary metabolic process phospholipid biosynthetic process phospholipid metabolic process organic substance metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process organic substance biosynthetic process cellular lipid metabolic process phosphate-containing compound metabolic process metabolic process cellular process cellular metabolic process lipid biosynthetic process primary metabolic process phospholipid biosynthetic process phospholipid metabolic process organic substance metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process organic substance biosynthetic process cellular lipid metabolic process phosphate-containing compound metabolic process metabolic process cellular process phosphorus metabolic process lipid metabolic process	membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR043130	CDP-alcohol phosphatidyltransferase, transmembrane domain	Homologous Superfamily
A, B	IPR049037	CDP-alcohol phosphatidyltransferase AF_2299-like, N-terminal domain	Domain
A, B	IPR048254	CDP-alcohol phosphatidyltransferase, conserved site	Conserved Site
A, B	IPR000462	CDP-alcohol phosphatidyltransferase	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	Choline/ethanolamine phosphotransferase	Choline/ethanolamine phosphotransferase 1

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	CDP-Alcohol Phosphotransferases	AF2299 CDP-alcohol phosphotransferase w. bound CMP

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.