Annotations: 4NUX

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08357	e4nuxA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Toll/Interleukin receptor TIR domain (From Topology)	T: Toll/Interleukin receptor TIR domain	F: PF08357	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08357	SEFIR domain (SEFIR)	SEFIR domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Interleukin-17 receptor A	protein binding binding signaling receptor binding molecular transducer activity interleukin-17 receptor activity transmembrane signaling receptor activity signaling receptor activity cytokine receptor activity immune receptor activity	multicellular organismal process regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process regulation of interleukin-5 production organic substance metabolic process positive regulation of biosynthetic process regulation of cytokine production organic substance biosynthetic process cytokine production regulation of multicellular organismal process multicellular organismal process regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process regulation of interleukin-5 production organic substance metabolic process positive regulation of biosynthetic process regulation of cytokine production organic substance biosynthetic process cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process interleukin-5 production positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process positive regulation of interleukin-5 production positive regulation of cellular biosynthetic process cellular response to stimulus response to organic substance response to stimulus cell surface receptor signaling pathway signaling response to cytokine interleukin-17A-mediated signaling pathway cytokine-mediated signaling pathway cell communication cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance signal transduction regulation of defense response regulation of response to external stimulus defense response response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress response to stress positive regulation of defense response inflammatory response adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains immune response immune system process adaptive immune response T-helper 17 type immune response interleukin-13 production positive regulation of interleukin-13 production regulation of interleukin-13 production interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production cell chemotaxis chemotaxis granulocyte migration leukocyte migration taxis granulocyte chemotaxis myeloid leukocyte migration cell migration cell motility leukocyte chemotaxis locomotion biological process involved in interspecies interaction between organisms response to other organism defense response to symbiont response to biotic stimulus defense response to other organism innate immune response response to external biotic stimulus organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process primary metabolic process protein catabolic process macromolecule catabolic process protein metabolic process organic substance catabolic process chemokine (C-X-C motif) ligand 1 production regulation of chemokine production chemokine production positive regulation of chemokine production regulation of chemokine (C-X-C motif) ligand 1 production positive regulation of chemokine (C-X-C motif) ligand 1 production fibroblast activation cell activation cellular response to interleukin-17 response to interleukin-17 interleukin-17-mediated signaling pathway defense response to fungus response to fungus positive regulation of interleukin-23 production interleukin-23 production regulation of interleukin-23 production response to virus regulation of cytokine production involved in inflammatory response production of molecular mediator involved in inflammatory response cytokine production involved in inflammatory response positive regulation of cytokine production involved in inflammatory response	cell periphery plasma membrane membrane cellular anatomical entity extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR043046	Interleukin-17 receptor A/B, FnIII-like domain 2 superfamily	Homologous Superfamily
A	IPR032356	Interleukin-17 receptor, fibronectin-III-like domain 1	Domain
A	IPR013568	SEFIR domain	Domain
A	IPR038683	Interleukin-17 receptor A/B, FnIII-like domain 1 superfamily	Homologous Superfamily
A	IPR039465	Interleukin-17 receptor-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q96F46	chronic mucocutaneous candidiasis immunodeficiency 51 brain ischemia psoriasis astrocytic tumor Cerebral Ischemia glioblastoma lung carcinoma medulloblastoma osteosarcoma pituitary cancer tuberculosis hepatocellular carcinoma malignant glioma nail disease chronic mucocutaneous candidiasis immunodeficiency 51 brain ischemia psoriasis astrocytic tumor Cerebral Ischemia glioblastoma lung carcinoma medulloblastoma osteosarcoma pituitary cancer tuberculosis hepatocellular carcinoma malignant glioma nail disease ovarian cancer candidiasis exocrine pancreatic carcinoma malignant pancreatic neoplasm pilocytic astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.