4NUU

Heterotrimer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4nuua1	All alpha proteins	Duffy binding domain-like	Duffy binding domain-like	Duffy binding domain	automated matches	(Plasmodium vivax Sal-1 ) [TaxId: 126793 ],	SCOPe (2.08)
A	d4nuua2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Plasmodium vivax Sal-1 ) [TaxId: 126793 ],	SCOPe (2.08)
B	d4nuub1	All alpha proteins	Duffy binding domain-like	Duffy binding domain-like	Duffy binding domain	automated matches	(Plasmodium vivax Sal-1 ) [TaxId: 126793 ],	SCOPe (2.08)
B	d4nuub2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Plasmodium vivax Sal-1 ) [TaxId: 126793 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Duffy binding domain-like	8078551	3001914	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Duffy binding domain-like	8078551	3001914	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Duffy_binding	e4nuuA1	A: alpha bundles	X: Duffy-binding-like domain, N-terminal subdomain (From Topology)	H: Duffy-binding-like domain, N-terminal subdomain (From Topology)	T: Duffy-binding-like domain, N-terminal subdomain	F: Duffy_binding	ECOD (1.6)
A	PTZ00176	e4nuuA2	A: alpha bundles	X: Duffy-binding-like domain, C-terminal subdomain (From Topology)	H: Duffy-binding-like domain, C-terminal subdomain (From Topology)	T: Duffy-binding-like domain, C-terminal subdomain	F: PTZ00176	ECOD (1.6)
B	Duffy_binding	e4nuuB1	A: alpha bundles	X: Duffy-binding-like domain, N-terminal subdomain (From Topology)	H: Duffy-binding-like domain, N-terminal subdomain (From Topology)	T: Duffy-binding-like domain, N-terminal subdomain	F: Duffy_binding	ECOD (1.6)
B	PTZ00176	e4nuuB2	A: alpha bundles	X: Duffy-binding-like domain, C-terminal subdomain (From Topology)	H: Duffy-binding-like domain, C-terminal subdomain (From Topology)	T: Duffy-binding-like domain, C-terminal subdomain	F: PTZ00176	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1310.20	Mainly Alpha	Up-down Bundle	5 helical Cullin repeat like	Duffy-antigen binding domain	CATH (4.3.0)
A	1.20.58.830	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	1.20.1310.20	Mainly Alpha	Up-down Bundle	5 helical Cullin repeat like	Duffy-antigen binding domain	CATH (4.3.0)
B	1.20.58.830	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF05424	Duffy binding domain (Duffy_binding)	Duffy binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Duffy receptor	identical protein binding protein binding binding host cell surface binding host cell surface receptor binding	-	membrane cellular anatomical entity
C	Duffy antigen/chemokine receptor	C-C chemokine binding protein binding binding chemokine binding cytokine binding molecular transducer activity signaling receptor activity G protein-coupled receptor activity transmembrane signaling receptor activity	response to stimulus defense response response to stress inflammatory response cellular response to stimulus regulation of biological process response to organic substance regulation of cellular process cell surface receptor signaling pathway signaling biological regulation response to cytokine response to chemokine cytokine-mediated signaling pathway response to stimulus defense response response to stress inflammatory response cellular response to stimulus regulation of biological process response to organic substance regulation of cellular process cell surface receptor signaling pathway signaling biological regulation response to cytokine response to chemokine cytokine-mediated signaling pathway cellular response to chemokine chemokine-mediated signaling pathway cell communication cellular response to chemical stimulus response to chemical G protein-coupled receptor signaling pathway cellular process cellular response to cytokine stimulus signal transduction cellular response to organic substance multicellular organismal process cellular biosynthetic process organic substance metabolic process regulation of cytokine production organic substance biosynthetic process cytokine production regulation of multicellular organismal process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of chemokine production regulation of cellular biosynthetic process regulation of gene expression biosynthetic process chemokine production regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process	membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle cell periphery membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle cell periphery plasma membrane membrane recycling endosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR043057	Erythrocyte binding antigen 175, C-terminal domain superfamily	Homologous Superfamily
A, B	IPR008602	Duffy-antigen binding domain	Domain
A, B	IPR021620	Erythrocyte binding antigen 175, C-terminal	Domain
A, B	IPR021015	Duffy-antigen binding, C-terminal	Domain
A, B	IPR042202	Duffy-antigen binding superfamily	Homologous Superfamily
A, B	IPR021032	Duffy-antigen binding, N-terminal	Domain
C	IPR005384	Duffy antigen/chemokine receptor	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C	Pharos: Q16570	malaria psoriasis subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor cystic fibrosis Emery-Dreifuss muscular dystrophy invasive ductal breast carcinoma myopathy pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma pterygium ulcerative colitis breast cancer Duchenne muscular dystrophy glioblastoma malaria psoriasis subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor cystic fibrosis Emery-Dreifuss muscular dystrophy invasive ductal breast carcinoma myopathy pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma pterygium ulcerative colitis breast cancer Duchenne muscular dystrophy glioblastoma lung adenocarcinoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm pituitary cancer Sjogren syndrome breast carcinoma ductal breast carcinoma in situ interstitial cystitis osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.