Annotations: 4NTQ

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	CdiI-like	8051338	4007315	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ECL CdiI-like	8055790	3002312	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF15526	e4ntqA1	A: beta meanders	X: Colicin E3 ribonuclease domain-like	H: Ribonuclease domain of colicin E3 (From Topology)	T: Ribonuclease domain of colicin E3	F: PF15526	ECOD (1.6)
B	PF18228	e4ntqB1	A: a+b two layers	X: ssDNA-binding transcriptional regulator domain-like	H: ssDNA-binding transcriptional regulator domain (From Topology)	T: ssDNA-binding transcriptional regulator domain	F: PF18228	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.380.20	Alpha Beta	Roll	Ribonuclease domain of colicin e3 (Residues 456-551)	Novel toxin 21 (CdiA), C-terminal domain	CATH (4.3.0)
B	3.30.2450.20	Alpha Beta	2-Layer Sandwich	Secreted effector protein pipB2 fold		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF15526	Novel toxin 21 (Ntox21)	Novel toxin 21	-	Family
B	PF18228	CdiI N-terminal domain (CdiI_N)	CdiI N-terminal domain	This is the N-terminal domain of Contact-dependent growth inhibition immunity (CdiI) proteins present in Enterobacter cloacae. CdiI proteins neutralize CdiA-CT toxins to protect toxin-producing cells from auto-inhibition. Structural homology searches ...	This is the N-terminal domain of Contact-dependent growth inhibition immunity (CdiI) proteins present in Enterobacter cloacae. CdiI proteins neutralize CdiA-CT toxins to protect toxin-producing cells from auto-inhibition. Structural homology searches reveal that Enterobacter cloacae's CdiI is most similar to the Whirly family of single-stranded DNA-binding protein [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Contact-dependent inhibitor A	endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity toxin activity	-	host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region cellular anatomical entity
B	ECL CdiI	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR008638	Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like, TPS domain	Domain
A	IPR012334	Pectin lyase fold	Homologous Superfamily
A	IPR028190	Novel toxin 21	Domain
A	IPR006914	VENN motif-containing domain	Domain
A	IPR025157	Hemagglutinin repeat	Repeat
A	IPR038181	Novel toxin 21 superfamily	Homologous Superfamily
A	IPR010069	Toxin CdiA-like, Filamentous hemagglutinin motif repeats	Repeat
A	IPR011050	Pectin lyase fold/virulence factor	Homologous Superfamily
B	IPR040509	CdiI, C-terminal	Domain
B	IPR040509	CdiI, C-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.