Annotations: 4NSC

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00036	e4nscA2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
A	PF13202	e4nscA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13202	ECOD (1.6)
B	PF00036	e4nscB3	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
B	PF13202	e4nscB2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13202	ECOD (1.6)
C	PF00036	e4nscC2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
C	PF13202	e4nscC1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13202	ECOD (1.6)
D	PF00036	e4nscD2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
D	PF13202	e4nscD1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13202	ECOD (1.6)
E	PF00036	e4nscE1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
E	PF13202	e4nscE2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13202	ECOD (1.6)
F	PF00036	e4nscF2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
F	PF13202	e4nscF1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13202	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF13202	EF hand (EF-hand_5)	EF hand	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Calcium uptake protein 1, mitochondrial	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein heterodimerization activity protein binding protein dimerization activity identical protein binding	transport monoatomic ion transmembrane transport inorganic ion transmembrane transport mitochondrial transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization import into the mitochondrion mitochondrial calcium ion transmembrane transport monoatomic ion transport transport monoatomic ion transmembrane transport inorganic ion transmembrane transport mitochondrial transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization import into the mitochondrion mitochondrial calcium ion transmembrane transport monoatomic ion transport cellular process calcium import into the mitochondrion monoatomic cation transport calcium ion transmembrane transport mitochondrial transport calcium ion import cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis mitochondrial calcium ion homeostasis inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis positive regulation of mitochondrial calcium ion concentration response to stimulus defense response response to stress cellular response to stimulus regulation of cellular hyperosmotic salinity response regulation of cellular process regulation of cellular response to stress cellular hyperosmotic salinity response cellular response to chemical stress response to salt stress regulation of response to osmotic stress cellular response to environmental stimulus hyperosmotic salinity response regulation of response to salt stress hyperosmotic response regulation of cellular response to osmotic stress cellular hyperosmotic response cellular response to stress regulation of response to stress response to osmotic stress regulation of biological process cellular response to salt stress biological regulation cellular response to osmotic stress cellular response to chemical stimulus regulation of response to stimulus response to chemical response to abiotic stimulus cellular response to abiotic stimulus	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane protein-containing complex transmembrane transporter complex membrane protein complex cation channel complex transporter complex calcium channel complex monoatomic ion channel complex mitochondrial intermembrane space membrane-enclosed lumen intracellular organelle lumen organelle envelope lumen organelle lumen uniplex complex mitochondrial protein-containing complex inner mitochondrial membrane protein complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A, B, C, D, E A, B, C, D, E, F	IPR039800	Calcium uptake protein 1/2/3	Family
A, B, C, D, E A, B, C, D, E, F	IPR002048	EF-hand domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR011992	EF-hand domain pair	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: Q9BPX6	proximal myopathy with extrapyramidal signs myopathy basal ganglia disease pancreatic intraductal papillary-mucinous carcinoma Adult Learning Disorders congenital muscular dystrophy muscle tissue disease osteosarcoma pancreatic intraductal papillary-mucinous neoplasm tuberculosis arthrogryposis learning disability movement disorder muscular disease ovarian cancer proximal myopathy with extrapyramidal signs myopathy basal ganglia disease pancreatic intraductal papillary-mucinous carcinoma Adult Learning Disorders congenital muscular dystrophy muscle tissue disease osteosarcoma pancreatic intraductal papillary-mucinous neoplasm tuberculosis arthrogryposis learning disability movement disorder muscular disease ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia intellectual disability malignant glioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.